Value of reduced glomerular filtration rate assessment with cardiometabolic index: insights from a population-based Chinese cohort

Abstract

BackgroundRecent studies have suggested that cardiometabolic index (CMI), a novel estimate of visceral adipose tissue, could be of use in the evaluation of cardiovascular risk factors. However, the potential utility and clinical significance of CMI in the detection of reduced estimated glomerular filtration rate (eGFR) remains uncertain. The purpose of this study was to investigate the usefulness of CMI in assessing reduced eGFR in the general Chinese population.MethodsThis cross-sectional analysis included 11,578 participants (mean age: 53.8 years, 53.7% females) from Northeast China Rural Cardiovascular Health Study (NCRCHS) of general Chinese population (data collected from January 2013 to August 2013). CMI was calculated by triglyceride to high density lipoprotein cholesterol ratio multiply waist-to-height ratio. Reduced eGFR was defined as eGFR< 60 ml/min per 1.73m2. Multivariate regressions were performed to determine CMI’s association with eGFR value and eGFR reduction, ROC analyses were employed to investigate CMI’s discriminating ability for decreased eGFR.ResultsThe prevalence of reduced eGFR was 1.7% in males and 2.5% in females. CMI was notably more adverse in reduced eGFR groups, regardless of genders. In fully adjusted multivariate linear models, each 1 SD increment of CMI caused 3.150 ml/min per 1.73m2 and 2.411 ml/min per 1.73m2 loss of eGFR before CMI reached 1.210 and 1.520 in males and females, respectively. In logistic regression analyses, per 1 SD increase of CMI brought 51.6% additional risk of reduced eGFR in males while caused 1.347 times of risk in females. After divided into quartiles, people in the top quartile of CMI had higher adjusted ORs of having reduced eGFR, with ORs of 4.227 (1.681, 10.627) and 3.442 (1.685–7.031) for males and females respectively. AUC of CMI was revealed to be 0.633 (0.620–0.646) in males and 0.684 (0.672–0.695) in females.ConclusionsHigher CMI was independently associated with greater burden of reduced eGFR, highlighting VAT distribution and dysfunction as a potential mechanism underlying the association of obesity with kidney damage and adverse cardiovascular outcomes. The findings from this study provided important insights regarding the potential usefulness and clinical relevance of CMI in the detection of reduced eGFR among general Chinese population.

Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population

“…Previously published studies have fully reported the methods of data collection and measurement [26,27]. Before the study, cardiologists and nurses must pass a strict exam to obtain the qualification for conducting questionnaires which collect baseline information about sociodemographic data, health-related behaviors, anthropometric indexes, and history of CVD.…”

Evaluation of Anthropometric Indices and Lipid Parameters to Predict Metabolic Syndrome Among Adults in Mexico

“…For example, LAP, CMI, and CRI-I were found to be effective proxy indicators of several health problems, including CVDs 36 , 37 and chronic kidney diseases. 38 , 39 However, the predictive power of these parameters did not match between studies representing different populations. The parameters have not been explored in Mexican populations before.…”

Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass

“…WC is regarded as a plausible surrogate marker for central obesity and serves as an indirect assessment of visceral adiposity in particular. Moreover, WC could better reflect visceral adipose tissue (VAT) when combined with TG [22]. With the development of obesity, VAT becomes dysfunctional, leading to an increased lipolysis rate.…”

“…One prospective study reported LAP was independently associated with the risk of incident cardiovascular diseases among women at a median of 8.6-year follow-up [35]. Likewise, CMI has been put forward as a premier marker for central adiposity [22]. Patients with higher CMI levels had greater HbA1c and predisposed to coronary artery diseases [23].…”

“…Recently, cardiometabolic index (CMI), a newly discovered index which was defined based on TG/HDL-C ratio and WC/height (WHtR), has been regarded as a prominent marker representing abdominal adipose [22]. This index has been used as a surrogate marker to determine the risk of developing T2DM [23,24] and coronary artery diseases [25].…”