LC determination of piroxicam in human plasma

Simultaneous determination of piroxicam, meloxicam and tenoxicam in human plasma by liquid chromatography with tandem mass spectrometry

“…Since the transdermal delivery avoids the gastrointestinal side effect and first-pass effect, many studies have been carried out in order to develop the percutaneous preparations of NSAIDs, including piroxicam and tenoxicam [1][2][3][4][5][6] number of high performance liquid chromatography (HPLC) methods with UV detection [7][8][9][10][11][12][13][14][15][16], amperometric detection [17] and tandem mass spectrometry (LC-MS/MS) [16,[18][19][20] were reported for the determination of piroxicam, meloxicam or tenoxicam in biological fluids; however, most of those methods presented insufficient sensitivity (limit of detection; 0.72-50 ng/ml), the use of large biological fluid volumes (0.25-1 ml plasma or urine) or chromatographic interferences. There was no LC-MS/MS method reported for the simultaneous determination of meloxicam, piroxicam and tenoxicam in biological samples.…”

Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection

“…Other workers [e.g. 28,31] reported HPLC methods using UV detection for the determination of PIR in plasma. These studies involved a direct protein precipitation but they used larger plasma volumes (200-500 L) and larger injected volumes (50-100 L).…”

“…GC methods are timeconsuming and have been largely replaced by HPLC methods with ultra-violet (UV) [25][26][27][28][29][30][31][32][33][34][35] detection, electrochemical detection [36], or mass spectrometry [37]. To our best knowledge, very few studies describe the analysis of NSAIDs via HPLC with fluorescence detection [38].…”

Carbon ceramic electrode incorporated with zeolite ZSM-5 for determination of Piroxicam

“…Other side effects such as headache, dizziness, skin rashes, palpitations, edema, and tinnitus are less important and infrequent [29]. Several methods have been proposed involving either spectroscopic or chromatographic techniques for the determination of Piroxicam in pharmaceuticals and biological fluids [30][31][32][33]. However, most of those methods presented insufficient sensitivity owing to the use of large biological fluid volumes or chromatographic interferences.…”