Determination of non-steroidal anti-inflammatory drugs in pharmaceuticals and human serum by dual-mode gradient HPLC and fluorescence detection

Simultaneous determination of non-steroidal anti-inflammatory drugs in pharmaceutical formulations and human serum by reversed phase high performance liquid chromatography

“…Furthermore, it is also very important to precisely quantify these NSAIDs in pharmaceutical formulations for quality control. 1 Until now, a variety of chromatographic methods have been proposed for the determination of NSAIDs in pharmaceutical formulations and biological fluids, by gas chromatography, 2-4 spectrofluorometry, 5 high performance liquid chromatography [6][7][8][9][10][11][12][13][14][15][16][17] and capillary electrophoresis. 18 Generally, it is impossible that one patient would be prescribed for more than one kind of NSAIDs at the same time; however simultaneous determination of these drugs is useful in pharmaceutical routine analysis and biological samples.…”

Electroanalysis of Mefenamic Acid in Pharmaceutical Formulation and Spiked Biological Fluids on Modified Carbon Nanotube Electrode

“…Due to the vital importance of mefenamic acid, it is essential to develop a simple, rapid and reliable technique for the determination of mefenamic acid. Spectrophotometric [5], solid phase extraction [6], atomic absorption spectrometry [7], NMR [8], chromatography [9][10][11][12][13] and flow injection spectrophotometry [14,15] are several analytical methods developed for the determination of mefenamic acid. Electrochemical techniques are extensively applied due to their sensitive properties and usually they do not require sample pretreatment that is time consuming and difficult [16,17].…”

Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma

“…There are several determination methods for naproxen and felbinac in pharmaceutical preparations and biological samples: methods based on liquid chromatography (LC) with UV detection [5][6][7][8], electrochemical detection [9,10], mass spectrometry (MS) method [11,12], and fluorescent detection [13][14][15]. In general, UV detection is not sensitive and selective, while electrochemical detection tends to lack reproducibility due to hysteretic degradation of the electrode.…”