Layered MoS2 nanosheets modified by biomimetic phospholipids: Enhanced stability and its synergistic treatment of cancer with chemo-photothermal therapy

Recent advancement in biomedical applications on the surface of two-dimensional materials: from biosensing to tissue engineering

“…223,224 A nice strategy to mitigate these issues, improve the biocompatibility and decrease even more the cytotoxicity is to perform the functionalization of the surface of Mos 2 with biocompatible materials and/or biomolecules. This was clearly demonstrated recently by Xie M. et al 225 The authors showed the modification of the MoS 2 surface with egg yolk phospholipids (MoS 2 -lipid) to enhance the stability of the MoS 2 nanosheets under physiological conditions and to act as a nanocarrier system for the treatment of tumors via the combination of chemotherapy and photothermal therapy. The MoS 2 -lipid demonstrated a loading rate of DOX of 104.4%, and a release mediated by pH and NIR light.…”

NIR‐II Responsive Inorganic 2D Nanomaterials for Cancer Photothermal Therapy: Recent Advances and Future Challenges

“…2D black phosphorus (BP) nanosheets, as typical semiconductor like graphene, [ 353–355 ] MoS 2 , [ 356–359 ] or WS 2 , [ 123 ] and Mxene, [ 225 ] has tunable bandgap and unique optical property to determine its application in cancer PTT. [ 360 ] Ultrahigh surface area to volume ratio provides plenty of anchoring points for anticancer drugs to make them ideal nanocarrier in drug delivery systems.…”

“…Especially, the 2D composites exhibited high sensitivity of fluorescence imaging, PA imaging, and photothermal imaging, indicating it can be used for deep solid cancer diagnosis therapy. For their further clinical translation, simple preparation strategies SnTebased theranostics nanoplatform need to be further developed for high NIR II-mediated clinical potential for cancer theranostics to overcome some possible complex preparation process 2D black phosphorus (BP) nanosheets, as typical semiconductor like graphene, [353][354][355] MoS 2 , [356][357][358][359] or WS 2 , [123] and Mxene, [225] has tunable bandgap and unique optical property to determine its application in cancer PTT. [360] Ultrahigh surface area to volume ratio provides plenty of anchoring points for anticancer drugs to make them ideal nanocarrier in drug delivery systems.…”

MoS2-based nanocomposites for cancer diagnosis and therapy

“…16 b-f). Furthermore, studies demonstrated that MoS 2 nanosheets modified by chitosan [ 237 ], hyperbranched polyglycidyl (HPG) [ 325 ] or egg yolk phospholipids [ 326 ] could also serve as nanoplatforms with good colloidal stability and biocompatibility to realize the synergistic treatment of chemotherapy and PTT. Time-staggered administration of erlotinib (Er) and DOX can enhance the anticancer effect, but its clinical application is limited due to different administration routes and formulation parameters.…”