Layered double hydroxide as novel antibacterial drug delivery system

Ryu, Sang Young; Jung, Hyunseung; Oh, Jae‐Min; Lee, Jin-Kyu; Choy, Jin‐Ho

doi:10.1016/j.jpcs.2009.12.066

Cited by 109 publications

(60 citation statements)

References 15 publications

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“…138 The designed nanocomposites retained antimicrobial activity against P. aeruginosa, with a very good minimum inhibitory concentration (65-137 μmol⋅L −1 ). 138 Many different antimicrobial agents, eg, amoxicillin 139 and cefazolin, 140 have been successfully intercalated into LDHs.…”

Section: Amino Acid Layered Double Hydroxidesmentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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Hydrotalcite-like compounds are two-dimensional inorganic nanolayers also known as clay minerals or anionic clays or layered double hydroxides/layered hydroxy salts, and have emerged as a single type of material with numerous biomedical applications, such as drug delivery, gene delivery, cosmetics, and biosensing. Inorganic nanolayers are promising materials due to their fascinating properties, such as ease of preparation, ability to intercalate different type of anions (inorganic, organic, biomolecules, and even genes), high thermal stability, delivery of intercalated anions in a sustained manner, high biocompatibility, and easy biodegradation. Inorganic nanolayers have been the focus for researchers over the last decade, resulting in widening application horizons, especially in the field of biomedical science. These nanolayers have been widely applied in drug and gene delivery. They have also been applied in biosensing technology, and most recently in bioimaging science. The suitability of inorganic nanolayers for application in drug delivery, gene delivery, biosensing technology, and bioimaging science makes them ideal materials to be applied for theranostic purposes. In this paper, we review the structure, methods of preparation, and latest advances made by inorganic nanolayers in such biomedical applications as drug delivery, gene delivery, biosensing, and bioimaging.

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Section: Amino Acid Layered Double Hydroxidesmentioning

confidence: 99%

Inorganic nanolayers: structure, preparation, and biomedical applications

Saifullah¹,

Hussein²

2015

IJN

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“…In this study TET was retained in the non-degraded form when bound to clay, despite prolonged incubation in water. Similarly, using zinc/aluminium LDH, Ryu et al bound and released cefazolin in the undegraded state and demonstrated antimicrobial activity of the clay/drug complex in vitro [12]. Clearly, the ability of clay complexation to maintain antibiotics in a non-degraded state for extended periods is a huge advantage in prolonged therapeutic applications.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Trikeriotis et al [11] successfully bound four different antibiotics, gramicidin, amphotericin B, ampicillin and nalidixic acid in nitrate layered aluminium/magnesium double hydroxides. Using zinc/aluminium LDH, Ryu et al [12] bound and released cefazolin in the non-degraded state and demonstrated antimicrobial activity of the LDH clay/ drug complex in vitro. To extend release times, Tammaro et al [13] manufactured a poly(caprolactone) film containing an LDH clay/antibiotic complex composed of a magnesium/aluminium LDH clay(nitrate counterion) with chloramphenicol.…”

Section: Introductionmentioning

confidence: 99%

The application of layered double hydroxide clay (LDH)-poly(lactide-co-glycolic acid) (PLGA) film composites for the controlled release of antibiotics

Chakraborti

Jackson

Plackett

et al. 2012

J Mater Sci: Mater Med

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Many sites of bacterial infection such as in-dwelling catheters and orthopedic surgical sites require local rather than systemic antibiotic administration. However, currently used controlled release vehicles, such as polymeric films, release water-soluble antibiotics too quickly, whereas nonporous bone cement, used in orthopedics, release very little drug. The purpose of this study was to investigate the use of nanoparticulates composed of layered double hydroxide clays to bind various antibiotics and release them in a controlled manner. Mg-Al (carbonate) layered double hydroxides were synthesized and characterized using established methods. These clay particles were suspended in solutions of the antibiotics tetracycline, doxorubicin (DOX), 5-fluorouracil, vancomycin (VAN), sodium fusidate (SF) and antisense oligonucleotides and binding was determined following centrifugation and quantitation of the unbound fraction by UV/Vis absorbance or HPLC analysis. Drug release from layered double hydroxide clay/drug complexes dispersed in polymeric films was measured by incubation in phosphate-buffered saline (pH 7.4) at 37 °C using absorbance or HPLC analysis. Antimicrobial activity of drug released from film composites was determined using zonal inhibition studies against S. epidermidis. All drugs bound to the clay particles to various degrees. Generally, drugs released with a large burst phase of release (except DOX) with little further drug release after 4 days. Dispersion of drug/clay complexes in poly(lactic-co-glycolic acid) films resulted in a reduced burst phase of release and a slow continuous release for many weeks with effective antimicrobial amounts of VAN and SF released at later time points. Layered double hydroxide clays may be useful for controlled release applications at sites requiring long-term antibiotic exposure as they maintain the drug in a non-degraded state and release effective amounts of drug over long time periods. LDH clay/drug complexes are amenable to homogenous dispersion in polymeric films where implant coating may be optimal or required.

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“…The bacterial strains, including 20 mL nutrient broth, 0.23 g of antibacterial samples, and 2 mL bacterial suspension containing E. coli and S. aureus species, respectively, were cultured in gas bath thermostatic shaker with 150 rpm/min at 37.5°C and the absorbance of blank control bacterial strains was tested to 0.5 McFarland standard at 600 nm [37]. Then, 100 μL the above bacterial suspension was diluted into different times in a petri dish and cultured in gas bath thermostatic shaker at 37.5°C for 24 h. Finally, the images of antibacterial effect were analyzed by formula (3) [38][39][40].…”

Section: Antibacterial Properties Of Resin Compositesmentioning

confidence: 99%

One-pot synthesis of acrylate resin and ZnO nanowires composite for enhancing oil absorption capacity and oil-water separation

Chi

et al. 2018

Adv Compos Hybrid Mater

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Inspired by the fast separation of oils, we synthesized a multi-functional oil-absorbable material, ZnO nanowires/acrylic ester composite resin, via a facile and cost-effective suspension polymerization method. Especially, the ZnO nanowires were fabricated by hydrothermal method and the surface of superhydrophobic and superoleophilic ZnO nanowires was modified by A151. Various technologies such as FT-IR, XRD, SEM, and DSC-TG have been used to investigate the properties of the assynthesized materials. The corresponding oil absorption results showed that the composite resins could effectively separate organics from wastewater. Moreover, the composite resins were proved to have an excellent reusability after 10 cycles and the antibacterial activity of the synthesized composite resins mixed with ZnO nanowires were confirmed against E. coli and S. aureus, which could play an important role in water purification. Herein, the as-synthesized multi-functional oil-absorbable resins possess a far-reaching application prospect in the field of environmental treatment.

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Layered double hydroxide as novel antibacterial drug delivery system

Cited by 109 publications

References 15 publications

Inorganic nanolayers: structure, preparation, and biomedical applications

Inorganic nanolayers: structure, preparation, and biomedical applications

The application of layered double hydroxide clay (LDH)-poly(lactide-co-glycolic acid) (PLGA) film composites for the controlled release of antibiotics

One-pot synthesis of acrylate resin and ZnO nanowires composite for enhancing oil absorption capacity and oil-water separation

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Layered double hydroxide as novel antibacterial drug delivery system

Cited by 109 publications

References 15 publications

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

Inorganic nanolayers: structure, preparation, and&nbsp;biomedical applications

The application of layered double hydroxide clay (LDH)-poly(lactide-co-glycolic acid) (PLGA) film composites for the controlled release of antibiotics

One-pot synthesis of acrylate resin and ZnO nanowires composite for enhancing oil absorption capacity and oil-water separation

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Product

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Inorganic nanolayers: structure, preparation, and biomedical applications

Inorganic nanolayers: structure, preparation, and biomedical applications