Layer-by-Layer assembled nano-drug delivery systems for cancer treatment

Zhang, Xinyi; Liang, Tianying; Ma, Qingming

doi:10.1080/10717544.2021.1905748

Cited by 41 publications

(20 citation statements)

References 151 publications

(161 reference statements)

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“…The encapsulation and delivery of anticancer drugs is extremely difficult due to the impact of different parameters, including their poor permeability in solid tumors, the difficulties associated with reaching the tumor, and the strong side effects associated with the systemic administration of drugs. The use of LbL capsules for encapsulating antitumoral drugs with a broad spectrum of activities provides important avenues for a more efficient antitumoral drug administration [144,243].…”

Section: Layer-by-layer Capsules For Anticancer Therapymentioning

confidence: 99%

Polyelectrolyte Multilayered Capsules as Biomedical Tools

et al. 2022

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Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.

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Section: Layer-by-layer Capsules For Anticancer Therapymentioning

confidence: 99%

Polyelectrolyte Multilayered Capsules as Biomedical Tools

et al. 2022

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“…The release of neoplastic drugs from the LbL system can be regulated in various ways—by changing the light intensity, temperature or pH. Target delivery of substances can also be controlled by various molecules that make up the surface of the LbL system, which are designed to bind to proteins on the surface of cancer cells [ 80 ].…”

Section: Medical Applications Of Nanomaterialsmentioning

confidence: 99%

The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases

Paluszkiewicz

Martuszewski

Zaręba

et al. 2021

IJMS

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Nanomedicine is currently showing great promise for new methods of diagnosing and treating many diseases, particularly in kidney disease and transplantation. The unique properties of nanoparticles arise from the diversity of size effects, used to design targeted nanoparticles for specific cells or tissues, taking renal clearance and tubular secretion mechanisms into account. The design of surface particles on nanoparticles offers a wide range of possibilities, among which antibodies play an important role. Nanoparticles find applications in encapsulated drug delivery systems containing immunosuppressants and other drugs, in imaging, gene therapies and many other branches of medicine. They have the potential to revolutionize kidney transplantation by reducing and preventing ischemia–reperfusion injury, more efficiently delivering drugs to the graft site while avoiding systemic effects, accurately localizing and visualising the diseased site and enabling continuous monitoring of graft function. So far, there are known nanoparticles with no toxic effects on human tissue, although further studies are still needed to confirm their safety.

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“…The emergence of nanotechnology has had a profound impact on the clinical treatment of tumors, which has promoted the rapid development of targeted therapy [64][65][66], combined drug therapy [67,68], and early tumor diagnosis [69]. Among them, NDDSs have become a research hotspot at the interface between nanotechnology and biomedicine, because of their efficient loading, targeted delivery, controlled release, and other functions for drugs, and show promise in biomedical applications [70,71]. For example, silicon-based nanomaterials [72], polymers [73], liposomes, and metal NPs [74] are designed to deliver anticancer drugs to tumor tissues.…”

Section: Introductionmentioning

confidence: 99%

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

Xia

Tao

Zhu

et al. 2021

IJMS

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Cancer is one of the primary causes of worldwide human deaths. Most cancer patients receive chemotherapy and radiotherapy, but these treatments are usually only partially efficacious and lead to a variety of serious side effects. Therefore, it is necessary to develop new therapeutic strategies. The emergence of nanotechnology has had a profound impact on general clinical treatment. The application of nanotechnology has facilitated the development of nano-drug delivery systems (NDDSs) that are highly tumor selective and allow for the slow release of active anticancer drugs. In recent years, vehicles such as liposomes, dendrimers and polymer nanomaterials have been considered promising carriers for tumor-specific drug delivery, reducing toxicity and improving biocompatibility. Among them, polymer nanoparticles (NPs) are one of the most innovative methods of non-invasive drug delivery. Here, we review the application of polymer NPs in drug delivery, gene therapy, and early diagnostics for cancer therapy.

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Layer-by-Layer assembled nano-drug delivery systems for cancer treatment

Cited by 41 publications

References 151 publications

Polyelectrolyte Multilayered Capsules as Biomedical Tools

Polyelectrolyte Multilayered Capsules as Biomedical Tools

The Application of Nanoparticles in Diagnosis and Treatment of Kidney Diseases

Targeted Delivery of Drugs and Genes Using Polymer Nanocarriers for Cancer Therapy

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