Polyelectrolyte Multilayered Capsules as Biomedical Tools

Abstract

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.

A decade of developing applications exploiting the properties of polyelectrolyte multilayer capsules

“…those serving as sensors and those having therapeutic functionality. 372 Microcapsules, designed with targeting capability and allowing prolonged release of drugs are of interest. 373,374 Sindeeva et al investigated the dynamics of blood flow parameters of the mice liver and kidneys after intravenous administration of magnetic microcapsules which would assist in imaging of damaged tissue areas in clinics, Fig.…”

Nanoarchitectonics beyond perfect order – not quite perfect but quite useful

“…211 It should be noted that the application range of microcapsules, particularly in biomedicine, is steadily growing. 170,212,213 Also, it can be added that polyelectrolyte multilayer capsules can be combined with polymeric films 214,215 to further extend the range of applications.…”

Chitosan-based layer-by-layer edible coatings application for the preservation of mandarin fruit bioactive compounds and organic acids

“…Extrinsic compensation is based on ion pairing with charged counter-ions. Upon LbL assembly, this extrinsic charge compensation is converted into intrinsic charge compensation, leading to the release of counter-ions and solvating water molecules, additionally providing an entropic driving force for the LbL assembly process ( Mateos-Maroto et al, 2022 ).…”