Latent Virus Infections and Their Possible Relevance to the Cancer Problem

Andrewes, C. H.

doi:10.1177/003591573903300201

Cited by 19 publications

(8 citation statements)

References 29 publications

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“…Finally we have been led to wonder whether such an upset may not be the fundamental cause of a particular disease, cancer. 109 When he made these remarks, Andrewes still had to contend with resistance to the idea that viruses were involved with cancer at all. By the time that Lwoff turned his attention to the bacteriophages and lysogeny, however, several definitive reports of viruses implicated in mammalian tumours had been published.…”

Section: Lessons From Lysogeny: Viruses and Tumour Aetiologymentioning

confidence: 99%

From obstacle to lynchpin: the evolution of the role of bacteriophage lysogeny in defining and understanding viruses

Kostyrka

Sankaran²

2020

Notes Rec.

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The phenomenon of bacteriophage lysogeny has played a vital role in understanding the nature of viruses more generally. Discovered in 1920, the phenomenon was first wielded by its discoverers as a challenge to the idea that bacteriophages might be autonomous infectious agents of exogenous origin, namely viruses. But by the 1950s, lysogeny had come to be understood as a key mechanism through which some bacteriophages interacted with their bacterial hosts. In this paper we consider the history of the status of bacteriophage lysogeny from obstacle to lynchpin in conceiving of viruses, paying particular attention to the contributions of Eugène and Élisabeth Wollman, Macfarlane Burnet and André Lwoff in effecting this transition. As Lwoff is often acknowledged to be the author of the ‘modern’ virus concept, this paper also retraces the precise experimental, theoretical and technical pathways that led him and his collaborators from their studies of lysogeny to the construction of the said concept. We discuss Lwoff's virus concept and the widening impact of his ideas, with special consideration of how lysogeny helped revolutionise the understanding virus–host-cell relationships in tumour viruses.

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Section: Lessons From Lysogeny: Viruses and Tumour Aetiologymentioning

confidence: 99%

From obstacle to lynchpin: the evolution of the role of bacteriophage lysogeny in defining and understanding viruses

Kostyrka

Sankaran²

2020

Notes Rec.

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“…On these it can be seen that the cell sometimes swells up and sometimes fades out without change of shape. Delbriick (27) noted, with a strain of B. coli, that the lysis with swelling up BACTERIAL VIRUSES (BACTERIOPHAGES) 9 and the lysis without change of shape can be made to occur at will by adjusting the virus concentration.…”

Section: Andsismentioning

confidence: 99%

“…Paralleling the antigenic complexity of most bacteria, there exists also a diversity of serologically distinct viruses that may attack the same bacterium. The subject has been reviewed thoroughly by Burnet (9). We will give only a brief survey of the results.…”

Section: Constant Periodmentioning

confidence: 99%

“…It has been verified by many other workers. Burnet (9) states that " the serological nature is one of the most definite intrinsic characteristics of a bacteriophage, and comparative serological work provides the best basis for a classifjcation of any large group of bacteriophages." (The constancy of the serological type of a virus strain stands in contrast with the comparative variability of the virus in its affinity to the host.…”

Section: B+ 'K -No Reactionmentioning

confidence: 99%

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Bacterial Viruses (Bacteriophages)

Delbrück

1942

Advances in Enzymology - And Related Areas of Molecular Biology

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“…The availability of such a technique is especially desirable because this virus has been isolated from several species of animals used in experimental work, e.g., from white mice by Traub (1935Traub ( , 1936, Findlay, Alcock and Stern (1936), L6pine and Sautter (1936), and Kasahara, Hamano and Yamada (1939), and from gray house mice by Armstrong and Sweet (1939) and Armstrong, Wallace and Ross (1940); from monkeys by Armstrong and Wooley (1935) and Coggeshall (1939); from guinea pigs by Kasahara and coworkers (1939); and from dogs by Dalldorf (1939) andHowitt (1939-40). Not infrequently the virus has been found in normal-appearing animals, and for that reason Andrewes (1939) has placed it in the group of "indigenous viruses." The capacity to produce an inapparent infection probably accounts for the relative ease with which the virus of lymphocytic choriomeningitis has been picked up as a contaminant during serial transmission of other viruses.…”

mentioning

confidence: 99%