Late-onset hypogonadism or ADAM: diagnosis

The effect of testosterone on cardiometabolic risk factors in atorvastatin-treated men with late-onset hypogonadism

“…Some middle-aged and elderly 21 men may develop late-onset hypogonadism (LOH), also known 22 under the names of androgen deficiency in the aging male, partial 23 androgen deficiency in the aging male or andropause, and defined as 24 a clinical and biochemical syndrome associated with advancing age, 25 characterized by typical symptoms, and deficiency in serum 26 testosterone levels [4]. Low testosterone levels in aging men is 27 accompanied by a decrease in muscle mass and strength, osteopenia 28 or osteoporosis, increased adiposity, decreased insulin sensitivity, 29 impaired sexual function, cognitive disturbances, and impaired 30 quality of life [5][6][7]. In the light of recent clinical studies, low plasma 31 testosterone levels are associated with increased cardiovascular 32 morbidity and mortality [8,9].…”

The association between hypogonadism symptoms with serum testosterone, FSH and LH in men

“…Follicle-stimulating hormone (FSH) has less pulsatility than LH and its increase indicates injury to somniferous tubules [6]. The latest Endocrinology Society Clinical Practice guideline (2010) considers a diagnosis of LOH based on the assessment of clinical symptoms and signs along with the measurement of the testosterone levels [12,13].…”