Late metastasis for malignant melanoma

Filizel, Füsun; Demirkesen, Cüyan; Yildu, Nurullah; Oruç, Nafi

doi:10.1111/j.1365-4362.1997.tb04167.x

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…Though the tumor thickness is a prognosis indicator, it is not an absolute predictor of the length of disease-free interval. Local lymphadenopathy and local skin metastasis are superior survival indicators than distant metastasis [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…In an uveal melanoma mouse model, Eyles and colleagues found the first single tumor cell to spread less than 3 weeks after the clinical onset of the primary tumor which demonstrated that immunosurveillance controls the growth of primary melanoma and check the metastatic outgrowth [ 20 ]. This theory was highlighted by the inadvertent transmission of melanoma through an organ donor to an organ recipient [ 10 ]. Furthermore, the fact that late metastasis bears the genetic signature of early disseminated tumor cell could be a proof of immunosurveillance-induced tumor dormancy [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

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Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review

Pescarini

Spanikova

Mbaidjol

et al. 2020

Case Reports in Surgery

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The incidence of cutaneous malignant melanoma has shown a drastic increase over recent decades, and approximately 70% of newly diagnosed melanoma are tumors with a Breslow thickness less or equal to 1 mm. In the literature, there are well-documented rare cases of late metastasis of thin melanoma, and given their growing incidence, it is expected in the future to see more cases of late recurrence. We present a case report of a metastatic cutaneous melanoma 25 years from diagnosis and a review of the literature. A 61-year-old female patient presented with a newly discovered asymptomatic nodule on her thigh. Her relevant past medical history included a completely excided lesion with Breslow 1.4 mm thickness in 1989 for which she was followed up according to the guidelines and subsequently declared cured after 10 years of surveillance. Fine-needle aspiration and cytological analysis of the lesion proved to be a subcutaneous localization of malignant melanoma. The lesion was completely excised, and the patient has remained disease free since her surgery. The aim of this case report is to emphasize that late metastasis remains uncommon but a definitive cure from melanoma cannot always be considered a disease-free interval of 10 years. Physicians should always be aware of previous melanoma diagnosis with newly discovered suspicious lesions. Better patient education could improve the detection of recurrence and secondary melanomas without any need for more frequent follow-up visits and a prolonged follow-up time.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review

Pescarini

Spanikova

Mbaidjol

et al. 2020

Case Reports in Surgery

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Late recurrence of malignant melanoma presenting as peritoneal "carcinomatosis"

2003

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Malignant melanoma is a relatively rare malignancy that arises from melanocytes and accounts for approximately 1% of all malignancies reported in the United States. Malignant melanoma can develop in any part of the skin or mucosal membranes. It metastasizes to all organs of the body and often demonstrates unpredictable metastatic behavior. Late recurrence of malignant melanoma, defined as occurring 10 or more years after diagnosis and treatment, is a rare but characteristic metastatic behavior of malignant melanoma. We present a case of a late recurrence of malignant melanoma presenting with diffuse peritoneal studding.

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Lentigines, nevi, and melanomas

Weedon¹

2010

Weedon's Skin Pathology

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Late metastasis for malignant melanoma

Cited by 4 publications

References 6 publications

Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review

Late Metastatic Melanoma after 25 Years: A Case Report and a Brief Literature Review

Late recurrence of malignant melanoma presenting as peritoneal "carcinomatosis"

Lentigines, nevi, and melanomas

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