Laser-exited fluorescence from normal and abnormal human thyroid cells: a pilot study

Abstract

The fluorescence spectra have been measured from endogenous (native) fluorophores in normal, diseased and tumor thyroid tissues. They were found to be sufficiently different for the technique to be used as the basis for tumor diagnosis. Papillar carcinoma. Fluorescence spectra emitted from normal (dashed line) and cancerous (solid line) thyroid tissues

Laser-induced fluorescence of oral mucosa cancer

“…The investigated samples of the pathology of the thyroid gland (post-operative materials from the hospital) were characterized by a variety of pathologies and different degrees of abnormality [1]. These studies were also accompanied by background disturbances that were caused by various schemes of personalized medication, which for its part is a separate topic of research.…”

Laser induced fluorescence model of human goiter

“…It is demonstrated that the LIF spectral functions and their intensities well-labeled such areas and represent a good tool for medical diagnostics of goiter and for the definition of the degree of abnormality and geometrical sizes of these areas. Laser induced fluorescence (LIF) spectroscopy has been widely explored for noninvasive detection of precancerous and cancerous development in the different human tissues [1][2][3][4], monitoring changes in metabolism [5], for transplantation purposes [6] and visualization of the microscopic architecture of tissue [7]. This technique studies the autofluorescence induced in the tissue by means of nonhazardous photon flux of laser radiation.…”

“…1-4. These spectral curves are normalized by the maximal LIF intensity amplitude and well-analyzable by our previous labeled LIF data for thyroid tissue in different pure pathological and normal conditions [4,10]. In general we can assume that the tissue samples consist of inclusions with different degrees of abnormality [10].…”

“…Laser induced fluorescence (LIF) spectroscopy has been widely explored for noninvasive detection of precancerous and cancerous development in the different human tissues [1][2][3][4], monitoring changes in metabolism [5], for transplantation purposes [6] and visualization of the microscopic architecture of tissue [7]. This technique studies the autofluorescence induced in the tissue by means of nonhazardous photon flux of laser radiation.…”

“…In our previous studies LIF in thyroid tissues was investigated [4,10]. Fluorescence spectral features that differentiate normal thyroid tissue, goiter, thyroid papillary carcinoma, follicular carcinoma and adenoma have been identified and empirically correlated with histological diagnosis.…”