Laryngeal osteosarcoma: Case report and literature review

Kuba, Kiyomi; Inoue, Hitoshi; Hayashi, Tetsuo; Matsumura, Satoko; Minami, Kazuhiko; Takajo, Humihiko; Morita, Kei; Nakahira, Mitsuhiko; Sugasawa, Masashi

doi:10.1002/hed.23767

Cited by 12 publications

(14 citation statements)

References 24 publications

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“…Former smoker (2PY) Bilateral lung metastases at 8 months Dysphonia, dyspnea for 4 months. LE Saitama Medical University, International Medical Center, Hidaka, Saitama, Japan Kuba et al [ 18 ] 2015 55/M. Non-smoker.…”

Section: Resultsmentioning

confidence: 99%

Characteristics of Laryngeal Osteosarcoma: A Critical Review

et al. 2020

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Laryngeal sarcomas constitute an extremely rare entity among head and neck malignancies. Furthermore, most of them are chondrosarcomas, and the osteogenic form remains a true rarity. In general, there is a lack of information on the characteristics of laryngeal osteosarcoma. Thus, we sought to critically review the existing world literature on laryngeal osteosarcoma in order to develop a more accurate clinicopathological profile of this malignancy. Laryngeal osteosarcoma has a predilection for elderly male patients, as 87% were male in the present series and the mean age was 62 years (range 32-80), and without a direct association with tobacco exposure. Osteosarcoma of the larynx is typically a highly malignant neoplasm that metastasizes early, has a propensity for hematogenous spread and also has a marked tendency to recur. Twelve (41%) out of the 29 cases in the present review with follow-up data had metastatic disease. The aspects that distinguish osteosarcoma from its differential diagnostic alternatives are discussed in this review.

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Section: Resultsmentioning

confidence: 99%

Characteristics of Laryngeal Osteosarcoma: A Critical Review

et al. 2020

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“…These events are reported to occur at 9.8 months and 11 months, respectively . Mortality due to laryngeal osteosarcoma occurred at 3‐20 months after surgery in >60% of the patients . The treatment of choice is wide excision.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of choice is wide excision. No benefit from RT has been seen, and chemotherapy has been suggested …”

Section: Discussionmentioning

confidence: 99%

“…The used grading system was the French system FNCLCC (Fédération Nationale de Centres de Lutte Contre le Cancer), which is based on necrosis, atypia and mitosis . All histological diagnoses were confirmed with several pathologic tools as appropriated (immunohistochemistry, electron microscopy and molecular diagnosis) to exclude more frequent malignancies like sarcomatoid carcinoma and other mimickers . We used descriptive statistics and inferential statistics with Cox's regression model and Kaplan‐Meier test for survival analysis.…”

Section: Methodsmentioning

confidence: 99%

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Primary laryngeal sarcomas in a Mexican population: Case series of eleven cases

Luna-Ortiz

Navarro-Santiesteban

Villavicencio-Valencia

et al. 2017

Clinical Otolaryngology

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KEYPOINTSLaringeal sarcomas were more prevalent in men (10 cases in our series, with a mean age of 53.8 years (range: 21-81 years).Most tumours were found to be supraglottic (four cases) and glottic (four cases), one subglottic, and two extended to all subsites in the larynx.The following treatments were performed: six patients underwent organ-preserving surgery, four patients had total laryngectomy and one patient refused treatment.Only two patients received adjuvant radiotherapy, and three (27.3%) patients experienced recurrence.The heterogeneity of these types of tumours makes them difficult to study. Prognosis depends on the sarcoma subtype and grade of differentiation.

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“…Although rare and most commonly reported in adults, there are primary neoplastic masses of laryngeal cartilages. Of these masses, 70% to 75% originate from cricoid cartilage, but there are also case reports of thyroid cartilage masses, including osteoma, osteosarcoma, and giant cell tumor . In addition, there is also a case report of a pseudomass of the thyroid cartilage, which was diagnosed pathologically as dystrophic cartilage lesion .…”

Section: Discussionmentioning

confidence: 99%