Laryngeal Cancer

Boffetta, Paolo

doi:10.1007/978-1-4471-2825-0_8

Cited by 2 publications

(1 citation statement)

References 63 publications

(13 reference statements)

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“…It is approximated that 13,660 new cases and 3660 deaths caused by laryngeal cancer in the United States in 2017 1 , while 26,400 new cases and 14,500 death cases in China 2 . Laryngeal squamous cell carcinoma (LSCC) occupies ~90% of all the larynx malignant tumors 3,4 . In spite of therapeutic advances, most advanced LSCC patients have not obtained a desired outcome in the last 20 years.…”

Section: Introductionmentioning

confidence: 99%

Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

Lin

Yang

et al. 2019

Cell Death Dis

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The burgeoning functions of many microRNAs (miRs) have been well study in cancer. However, the level and function of miR-1205 in laryngeal squamous cell cancer remains unknown. In the current research, we validated that miR-1205 was notably downregulated in human laryngeal squamous cell carcinoma (LSCC) samples in comparison with tissues adjacent to LSCC, and correlated with T stage, lymph node metastasis, and clinical stage. Using Kaplan–Meier analysis indicates that high expression of miR-1205 has a favorable prognosis for patients with LSCC. Functional assays show that enforced miR-1205 expression attenuates the migration, growth, and invasion of LSCC cells. And E2F1 is verified to be a target of miR-1205, while E2F1 binds to miR-1205 promoter and transcriptionally inhibits miR-1205 expression. Overexpression of E2F1 reverses the inhibitory impacts of miR-1205 on LSCC cells in part. Importantly, E2F1 is abnormally increased in LSCC tissues, and its protein levels were inversely relevant to miR-1205 expression. High E2F1 protein level is in connection with clinical stage, T stage, lymph node metastasis, and poor prognosis. Consequently, reciprocal regulation of miR-1205 and E2F1 plays a crucial role in the progression of LSCC, suggesting a new miR-1205/E2F1-based clinical application for patients of LSCC.

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Section: Introductionmentioning

confidence: 99%

Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

Lin

Yang

et al. 2019

Cell Death Dis

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Exposure to silicon carbide and cancer risk: a systematic review

Boffetta

Hashim

2016

Int Arch Occup Environ Health

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The increased risk of lung cancer detected in the SiC production industry appears to be associated with high exposure levels to total dust, including crystalline silica and cristobalite which occurred in this industry in the past decades. It may not persist under current exposure circumstances, characterized by lower levels and use of personal protection equipment. Commercial users of SiC-based products were not affected.

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Laryngeal Cancer

Cited by 2 publications

References 63 publications

Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

Reciprocal regulation of miR-1205 and E2F1 modulates progression of laryngeal squamous cell carcinoma

Exposure to silicon carbide and cancer risk: a systematic review

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