Exposure to silicon carbide and cancer risk: a systematic review

Boffetta, Paolo; Hashim, Dana

doi:10.1007/s00420-016-1169-8

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…Crystalline silica is a known carcinogen for bronchopulmonary cancers and also an environmental factor involved in the development of SSc (120). Many other environmental components have been suspected or confirmed as playing a role in the emergence of SSc, such as organic solvents, pollutants, welding fumes, pesticides, etc (121–124).…”

Section: Shared Mechanisms In Cancer and Systemic Sclerosismentioning

confidence: 99%

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

et al. 2019

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Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.

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Section: Shared Mechanisms In Cancer and Systemic Sclerosismentioning

confidence: 99%

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

et al. 2019

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“…One study reported increased respiratory cancer rates in a metal fabrication facility [ 75 ]; however, those cases also included mesothelioma and laryngeal cancer. A systematic review found an increased lung cancer risk in silicon carbide workers [ 76 ]. As these workers were also exposed to silica dust, no clear attribution to hard metals could be concluded.…”

Section: Resultsmentioning

confidence: 99%

Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis

Krabbe,

Steffens,

Drießen

et al. 2024

Eur Respir Rev

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Background:Molecular pathways found to be important in pulmonary fibrosis are also involved in cancer pathogenesis, suggesting common pathways in the development of pulmonary fibrosis and lung cancer.Research question:Is pulmonary fibrosis from exposure to occupational carcinogens an independent risk factor for lung cancer?Study design and methods:A comprehensive search of PubMed, Embase, Web of Science and Cochrane databases with over 100 search terms regarding occupational hazards causing pulmonary fibrosis was conducted. After screening and extraction, quality of evidence and eligibility criteria for meta-analysis were assessed. Meta-analysis was performed using a random-effects model.Results:52 studies were identified for systematic review. Meta-analysis of subgroups identified silicosis as a risk factor for lung cancer when investigating odds ratios for silicosis in autopsy studies (OR 1.47, 95% CI 1.13–1.90) and for lung cancer mortality in patients with silicosis (OR 3.21, 95% CI 2.67–3.87). Only considering studies with an adjustment for smoking as a confounder identified a significant increase in lung cancer risk (OR 1.58, 95% CI 1.34–1.87). However, due to a lack of studies including cumulative exposure, no adjustments could be included. In a qualitative review, no definitive conclusion could be reached for asbestosis and silicosis as independent risk factors for lung cancer, partly because the studies did not take cumulative exposure into account.Interpretation:This systematic review confirms the current knowledge regarding asbestosis and silicosis, indicating a higher risk of lung cancer in exposed individuals compared to exposed workers without fibrosis. These individuals should be monitored for lung cancer, especially when asbestosis or silicosis is present.

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“…B offetta et al . [ 93 ] reported an increased risk of lung cancer with elevated crystalline silica concentrations, especially cristobalite exposure in silicon carbide production workers. Though silicosis is predominantly seen in construction and stone workers, miners and coal workers involved in mining operations like sandblasting, surface drilling and roof bolting are exposed to high levels of RCS dust clouds for extended periods.…”

Section: Occupational Dust-associated Lung Diseasesmentioning

confidence: 99%

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease

et al. 2022

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Workers in the mining and construction industries are at increased risk of respiratory and other diseases as a result of being exposed to harmful levels of airborne particulate matter (PM) for extended periods of time. While clear links have been established between PM exposure and the development of occupational lung disease, the mechanisms are still poorly understood. A greater understanding of how exposures to different levels and types of PM encountered in mining and construction workplaces affect pathophysiological processes in the airways and lungs and result in different forms of occupational lung disease is urgently required. Such information is needed to inform safe exposure limits and monitoring guidelines for different types of PM and development of biomarkers for earlier disease diagnosis. Suspended particles with a 50% cut-off aerodynamic diameter of 10 µm and 2.5 µm are considered biologically active owing to their ability to bypass the upper respiratory tract's defences and penetrate deep into the lung parenchyma, where they induce potentially irreversible damage, impair lung function and reduce the quality of life. Here we review the current understanding of occupational respiratory diseases, including coal worker pneumoconiosis and silicosis, and how PM exposure may affect pathophysiological responses in the airways and lungs. We also highlight the use of experimental models for better understanding these mechanisms of pathogenesis. We outline the urgency for revised dust control strategies, and the need for evidence-based identification of safe level exposures using clinical and experimental studies to better protect workers’ health.

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Exposure to silicon carbide and cancer risk: a systematic review

Cited by 8 publications

References 31 publications

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis

Understanding the pathogenesis of occupational coal and silica dust-associated lung disease

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