Larvicidal activity of neem oil (Azadirachta indica) formulation against mosquitoes

Dua, V. K.; Pandey, A. C.; Raghavendra, Kamaraju; Gupta, Ashish; Sharma, Trilochan; Dash, A. P.

doi:10.1186/1475-2875-8-124

Cited by 122 publications

(92 citation statements)

References 12 publications

(10 reference statements)

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“…On the other hand emulsified neem oil formulation was observed against A. stephensi larvae in tank and pits. Hundred percent of reductions were observed by V.K Dua et al 43 However in the present study combined activity of plant extract of T. purpurea and B. sphaericus in the field were 44.74%, 79.95% and 100% at 24 hrs, 48 hrs and 72 hrs respectively. This results show that T. purpurea and B. sphaericus can control the dengue vector, A. aegepti.…”

Section: Discussioncontrasting

confidence: 50%

Mosquito Larvicidal and Pupicidal Activity of Tephrosia purpurea Linn. (Family: Fabaceae) and Bacillus sphaericus against, Dengue Vector, Aedes aegypti

Venkadachalam¹,

Subramaniyan²,

Palani³

et al. 2017

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Objective:The bio-efficacy of Tephrosia purpurea leaf extract and bacterial insecticide, Bacillus sphaericus larvicidal activity was assessed against the first to fourth instars larvae of Aedes aegypti, under the laboratory conditions. Methods: The plant material was shade dried at room temperature and powdered coarsely. T. purpurea and B. sphaericus show the various concentrations of larvicidal and pupicidal activity against various instars larvae of A. aegypti. Results: The LC 50 of T. purpurea against the first to fourth instars larvae were 139. 24, 176.24, 219.28, 256.27, and 326.29 A. aegypti in all the tested concentrations than the individuals and clearly established that there is a substantial amount of synergist act. Conclusion: The present study reported that both T. purpurea and B. sphaericus materials could serve as a potential larvicidal agent. Since, A. aegypti is a container breeder vector mosquito this user and eco-friendly and low-cost vector control strategy could be a viable solution to the existing dengue disease burden. Therefore, this study provides first report on the mosquito larvicidal activity the combined effect of T. purpurea leaf extract and B. sphaericus against as target species of A. aegypti.

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Section: Discussioncontrasting

confidence: 50%

Mosquito Larvicidal and Pupicidal Activity of Tephrosia purpurea Linn. (Family: Fabaceae) and Bacillus sphaericus against, Dengue Vector, Aedes aegypti

Venkadachalam¹,

Subramaniyan²,

Palani³

et al. 2017

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“…Current control is based on the use of insecticides (chlorpyrifos, dichlorvos, cypermethrin) which have a potential toxic effect on public health and the environment. There is considerable international interest in developing benign natural products as an alternative to harmful synthetic pesticides to control invertebrate pests of medical and economic importance [2,3] . Botanical phytochemicals with mosquitocidal potential are now recognized as potent alternative insecticides to replace synthetic insecticides in mosquito control programs due to their excellent larvicidal, pupicidal and adulticidal properties [4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

Tagetes erecta Linn. and its mosquitocidal potency against Culex quinquefasciatus

Nikkon

Habib

Saud

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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“…Most parts of this plant, including its seed oil, have been traditionally valuable for their potent antimicrobial, antiinflammatory, antipyretic, analgesic, immunostimulatory, antiulcerous and antioxidant effects [1,2] . Its vital constituents are the triterpenoid azadirachtin complex, protomeliacins, limonoids, gedunin and its derivatives, vilasinin and c-secomeliacins like nimbin, salanin and dihydrochalcone, flavonoids, coumarin and tannins [3,4] .…”

Section: Banerjee Et Al: Novel Neem Oil Emollient Creammentioning

confidence: 99%

Azadirachta indica A. Juss Based Emollient Cream for Potential Dermatological Applications

Banerjee¹,

Thiagarajan²

2016

pharmaceutical-sciences

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Banerjee, et al.: Novel Neem Oil Emollient CreamAzadirachta indica A. Juss (Neem) is widely regarded to be an important medicinal tree whose parts and extracts are known to cure several ailments since the Vedic era. But knowledge regarding their concoctions and dosages has remained largely esoteric. Dilute neem oil emulsions are used to deliver active ingredients to body parts by the topical route of administration. This possibly attenuates its dose dumping and concentration related noxious effects to a large extent. However, almost all such products incorporate synthetic organic and bio hazardous chemicals for purposes of formulation and stability, posing ultimate risks to the user. Hence in the present study, an emollient cream using 10% neem oil and an arachidyl glucoside emulsifier of completely biological origin has been formulated. Octa and hexadecanoic acid derivatives were the major fatty acid components identified in the oil. The creamy white product showed a mean particle size of 137 nm and a Z average of 19 nm, with a polydispersity index of 0.245. Zeta potential and electrophoretic mobility were measured as -47.2 and -0.000328 cm 2 /Vs, respectively thus conferring good stability. FTIR analysis revealed the incidence of extensive hydrogen bonding in its structure and SEM image captured its undulating surface topography. The emollient cream was not susceptible to cracking, creaming or phase separation even after a period of 180 days, when stored at 37° or under low speed centrifugation. Similar results were observed when it was stored at 40°, 4° and -18° for three days and brought to 37° for three cycles. It is concluded that this novel potentially non-toxic neem oil emollient cream can either be used per se or as a base matrix for loading active ingredients and hence function as an efficient delivery system for the same.Key words: Azadirachta indica, neem oil, arachidyl glucoside, emollient cream, delivery system Azadirachta indica A. Juss, commonly known as neem or Indian lilac, belongs to Meliaceae family. Most parts of this plant, including its seed oil, have been traditionally valuable for their potent antimicrobial, antiinflammatory, antipyretic, analgesic, immunostimulatory, antiulcerous and antioxidant effects [1,2] . Its vital constituents are the triterpenoid azadirachtin complex, protomeliacins, limonoids, gedunin and its derivatives, vilasinin and c-secomeliacins like nimbin, salanin and dihydrochalcone, flavonoids, coumarin and tannins [3,4] . Along with a dozen minor azadirachtin analogs, they contribute to the overall efficacy of the oil when incorporated in cosmetic, cosmeceutical and pharmaceutical formulations [5] . The oil has been considered non-toxic and safe to mammalian species till a dosage of 5000 mg/kg of body weight. But the probability of risk due to its usage in concentrated form is of considerable concern as reported from several studies [6][7][8][9] . Hence, its crude and concentrated forms may pose limitations with respect to handling, usage and dose dumping, raising to...

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Larvicidal activity of neem oil (Azadirachta indica) formulation against mosquitoes

Cited by 122 publications

References 12 publications

Mosquito Larvicidal and Pupicidal Activity of Tephrosia purpurea Linn. (Family: Fabaceae) and Bacillus sphaericus against, Dengue Vector, Aedes aegypti

Mosquito Larvicidal and Pupicidal Activity of Tephrosia purpurea Linn. (Family: Fabaceae) and Bacillus sphaericus against, Dengue Vector, Aedes aegypti

Tagetes erecta Linn. and its mosquitocidal potency against Culex quinquefasciatus

Azadirachta indica A. Juss Based Emollient Cream for Potential Dermatological Applications

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