Large-scale genome duplications and paralog divergence in fish

Ozernyuk, N. D.; Myuge, N. S.

doi:10.1134/s1022795413010080

Cited by 6 publications

(1 citation statement)

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“…It can occur via natural selection or completely neutrally [45,54,55]. Multiple examples for each of these models were obtained from a great variety of organisms (see, for example, [56][57][58][59]). The studies of young duplicated genes were most informative, because many details associated with the emergence of new genes remained a mystery [60].…”

Section: The Fate Of Duplicated Genesmentioning

confidence: 99%

The birth and death of genes

2015

Russ J Genet

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Duplications of DNA regions with subsequent divergence of the duplicated copies by mutations is traditionally considered to be the major mechanism of the new genes appearance. After duplication, only a small fraction of the paralogs remains unchanged, while most copies are converted into pseudogenes or acquire new functions as a consequence of either subfunctionalization or neofunctionalization events. In some cases, certain regions of duplicated copies can combine with each other, giving rise to functionally new genes. Analysis of the primate genomes revealed a burst of segmental duplications in apes. It was demon strated that some of these duplications include genes that are specifically duplicated only in humans. Genome sequencing, followed by transcriptome analysis, enabled the identification of transcribed pseudogenes in mammalian genomes, that contradicts with the traditional view of pseudogenes as inactive copies of func tioning genes.

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