Abstract:Duplications of DNA regions with subsequent divergence of the duplicated copies by mutations is traditionally considered to be the major mechanism of the new genes appearance. After duplication, only a small fraction of the paralogs remains unchanged, while most copies are converted into pseudogenes or acquire new functions as a consequence of either subfunctionalization or neofunctionalization events. In some cases, certain regions of duplicated copies can combine with each other, giving rise to functionally … Show more
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