Large-pore, silica particles with antibody-like, biorecognition sites for efficient protein separation

Abstract

The MI-LPSPs, with antibody-like, bio-recognition sites, displayed good affinity and excellent binding selectivity to BSA.

Nanomaterials‐Based Surface Protein Imprinted Polymers: Synthesis and Medical Applications

“…The uniformity of the recognition sites affects the adsorption properties of MIPs, and further determines its reusability in practical applications. [ 78 ] Ambrosini's research team successfully prepared a trypsin imprinted polymer on the surface of SiO 2 through template immobilization method (Figure 3b). [ 79 ] It is worth noting that this imprinting process did not immobilize the integral protein directly, but the affinity ligand of the target protein, making the imprinting material universally applicable.…”

Curcumin-loaded metal oxide aerogels: supercritical drying and stability

“…Although these materials were reported for the rst time in 1931 by S. S. Kistler, 17 their broad range of technological applications increased noticeably in the last decades with potential uses for thermal 18 and acoustic insulation, 19 photoluminescence 20 and radioluminescence devices, 21 as adsorbents, 8,[22][23][24][25] catalysts, 12,26 and catalyst supports. [27][28][29][30] Furthermore, hybrid organic-inorganic aerogels were found to be promising materials as optical components, 31,32 insulating materials in microelectronics, 33 host materials for sensors, 34 and for drug delivery. 35 Curcumin (IUPAC name: (E)-1,7-bis(4-hydroxy-3methoxyphenyl)hept-3-ene-1,6-dione) is a polyphenol extracted from the Curcuma Longa rhizomatous herbaceous perennial plant.…”

Magnetic mesoporous silica/graphene oxide based molecularly imprinted polymers for fast selective separation of bovine hemoglobin

“…Although the molecular imprinting in the field of small molecule was successful, the biomacromolecule including protein [7,13], peptide [14], cell [15] and viruse [16] imprinting technique has been limited due to their large dimensions, chemical and structural complexity, slow mass transfer and environmental instability [17]. Certainly, a diversity of strategies such as surface imprinting [18,19], epitope imprinting [20,21], boronate affinity molecular imprinting [22] and microcontact imprinting have also been developed to overcome these limitations. Due to the recognition site was attached to the surface of material, surface imprinting has been proved as a prior strategy for improving the performance of biomacromolecule imprinted polymers.…”

“…In recent years, Fe 3 O 4 particles [5,12,13], graphene oxide (GO) [23], mesoporous silica particles [21,25], and carbon tubes [1,26] have been widely applied as the supporting substance for biomacromolecule imprinting. GO is a kind of two-dimensional carbon material that contains various oxygen-containing functional groups including hydroxyl, carboxyl, and epoxy groups, which help to graft of imprinted layer on the surface during the preparation of MIPs.…”