Large mucosa‐associated lymphoid tissue lymphoma simulating multiple polypoid lesions at the cecum and rectum

Onishi, Yutaka; Fujisawa, Takashi; Maeda, Mitsuo; Sakamoto, Norikazu; Sakaguchi, Kazuhiko; Kuroda, S.; Toyoda, Masanori; Teranishi, Tetsuya; Miyamoto, Katsufumi; Kusumoto, Chosei; Nishigami, Takayuki

doi:10.1046/j.1443-1661.2001.00139.x

Cited by 5 publications

(3 citation statements)

References 11 publications

(12 reference statements)

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“…Devido à raridade desta doença as dúvidas a respeito do diagnóstico e terapia ainda estão presentes. O estômago é o local mais comumente envolvido por linfoma MALT, respondendo por aproximadamente 70% de todos os casos [5,6]. O comprometimento do reto pelo linfoma MALT é uma entidade raramente encontrada e em mulheres seu achado é ainda mais escasso.…”

Section: Discussionunclassified

“…Doença inflamatória intestinal e imunossupressão (após transplante, AIDS, ou distúrbio imunitário) têm sido relatados como sendo fatores de risco para o surgimento de linfoma MALT [4]. O linfoma MALT desenvolve-se em diversas localizações anatômicas, como por exemplo, estômago (70% de todos os casos), glândula salivar, da tireóide e mama, entretanto, o acometimento colorretal é muito raro [5][6].…”

Section: Introductionunclassified

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Linfoma Malt Em Reto: Regressão Completa Após Quimioterapia R-Chop

Azevedo

Filho

Machado

et al. 2015

Rev. Cient. Fac. Med Campos

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Os linfomas de tecido linfoide associado à mucosa (MALT) são linfomas não Hodgkin de células B que podem surgir em diversas áreas extra nodais, sendo mais frequentes nos estômago. A apresentação primária em reto é particularmente rara, havendo poucos relatos de casos. Por sua raridade, não há consenso sobre a melhor forma de tratamento. Objetivo: Descrever um caso de linfoma MALT em reto, em uma paciente do sexo feminino e a sua resposta ao tratamento quimioterápico R-CHOP (rituximab, ciclofosfamida, doxorrubicina, vincristina e prednisona). Métodos: Estudo descritivo na forma de relato de casos e revisão de literatura. Relato de caso: Mulher de 55 anos iniciou há 4 anos, quadro clínico de hematoquezia e tenesmo, associada a distensão e sensação de plenitude abdominal. Evoluiu com queixas de astenia e dor do tipo cólica de fraca intensidade em hipocôndrio esquerdo. Apresentava histó- rico de câncer de mama tratada cirurgicamente e com quimioterapia há 7 anos. Após investigação foi realizado o diagnóstico de linfoma MALT de reto, classificado com estádio II pela classificação de Ann Arbor. Paciente recebeu 8 ciclos de quimioterapia do regime R-CHOP e obteve remissão completa do tumor. Conclusões: Tendo em vista a raridade da apresentação do linfoma MALT primário de reto e da ausência de consenso sobre o tratamento ideal, observamos que, através do presente caso, o tratamento quimioterápico com o protocolo R-CHOP possibilita atingir remissão completa de forma eficaz e segura.

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Section: Discussionunclassified

Section: Introductionunclassified

Linfoma Malt Em Reto: Regressão Completa Após Quimioterapia R-Chop

Azevedo

Filho

Machado

et al. 2015

Rev. Cient. Fac. Med Campos

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“…Onishi et al . found 68 cases of colorectal MALT lymphoma in the literature, and reported that only five cases (7.2%) were treated endoscopically 8 . Schmid et al .…”

Section: Discussionmentioning

confidence: 99%

Endoscopic removal of primary B‐cell mucosa‐associated lymphoid tissue lymphoma of the cecum

Koyama¹,

Yamashita²,

Sakurazawa³

et al. 2003

Digestive Endoscopy

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A 61‐year‐old woman with a history of positive fecal occult blood test was referred for further evaluation. She was symptom‐free and had no family history of colorectal cancer. Colonoscopy revealed a semipedunculated polyp with a surface of normal appearance. Although a biopsy specimen revealed inflammatory cells including numerous small lymphocytes in the mucosa, a definitive diagnosis was not made. Four weeks later, endoscopic removal using the submucosal injection method was performed for diagnosis as well as treatment. The tumor measured 14 × 13 × 6 mm. The pathological diagnosis was low‐grade B‐cell mucosa‐associated lymphoid tissue (MALT) lymphoma, and the depth of invasion was estimated as the submucosal layer. The case described here suggests that MALT lymphoma should be added to the differential diagnosis of colorectal submucosal tumors, and some cases of them might be resected endoscopically using the submucosal injection method.

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Primary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Occurring in the Rectum: A Case Report and Review of the Literature

Ahlawat

Kanber

Charabaty-Pishvaian

et al. 2006

Southern Medical Journal

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The primary extranodal B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct clinical pathologic entity that develops in diverse anatomic locations such as the stomach, salivary gland, thyroid, lung, and breast; however, colorectal involvement is rare. To the best of our knowledge, only 30 cases of primary rectal MALT lymphoma have been published in the English language literature, mostly from Japan. A single case has been reported from the US before this report. The most common symptoms ranged from asymptomatic to occult or gross gastrointestinal bleeding. Simultaneous involvement of the cecum or colon was seen in 20% of the patients. Ninety percent of the patients were classified as low grade, Stage 1 at the time of diagnosis. Polypoid lesions were 10-fold more common than ulcerative lesions. Seven patients were reported to have H pylori in the stomach. The majority of the patients underwent surgical or endoscopic resection as a cure; however, controversy exists with regards to antibiotic treatment or observation alone because of unknown etiopathogenesis. Infection with microorganisms other than H pylori has been postulated in the development of rectal MALT lymphoma; however, this hypothesis remains unproven. The overall prognosis of rectal MALT lymphoma appears favorable; however, long-term follow-up data is lacking. Therefore, periodic clinical monitoring should be done in these patients.

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Large mucosa‐associated lymphoid tissue lymphoma simulating multiple polypoid lesions at the cecum and rectum

Cited by 5 publications

References 11 publications

Linfoma Malt Em Reto: Regressão Completa Após Quimioterapia R-Chop

Linfoma Malt Em Reto: Regressão Completa Após Quimioterapia R-Chop

Endoscopic removal of primary B‐cell mucosa‐associated lymphoid tissue lymphoma of the cecum

Primary Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Occurring in the Rectum: A Case Report and Review of the Literature

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