Large Animal Studies to Reduce the Foreign Body Reaction in Brain–Computer Interfaces: A Systematic Review

Mian, Shan Yasin; Honey, Jonathan R; Carnicer‐Lombarte, Alejandro; Barone, Damiano G.

doi:10.3390/bios11080275

Cited by 4 publications

(3 citation statements)

References 66 publications

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“…Numerous studies implanted microwires or an MEA into the cerebral cortex and muscle tissue for a long duration (>6 months) and found no serious inflammation or immune reaction [ 60 , 61 , 62 ]. We implanted fMEAs into the spinal cord for more than one month at most and the arrays were working.…”

Section: Discussionmentioning

confidence: 99%

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

et al. 2021

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Neural interfaces typically focus on one or two sites in the motoneuron system simultaneously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating microarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.

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Section: Discussionmentioning

confidence: 99%

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

et al. 2021

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“…This is consistent with the fact that the attenuation coefficient that is higher in the chicken tissue than in PBS. [34][35][36] Considering the echo signal (Figure 8a green curve), the amplitude varies by 80 μV over the 500 mV range applied between the gate and the source. The maximum sensitivity is ≈350 μV V −1 which is lower than in PBS (Figure 8b).…”

Section: Ultrasound-based Interrogation Of the Gsgfet State In Chicke...mentioning

confidence: 99%

Graphene Solution‐Gated Field‐Effect Transistor for Ultrasound‐Based Wireless and Battery‐Free Biosensing

Sharma,

Lernoud,

Fain

et al. 2023

Adv Materials Technologies

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The development of wireless and battery‐free sensors for biomedical applications is a fast growing research and industrial field. It promises to greatly improve the patient's comfort during the diagnosis phase, but also in the treatment of chronic diseases. While the standard technologies are based so far on electromagnetic waves, ultrasonic powering and communication is offering perspectives to further reduce the size of the sensor in order to develop minimally invasive electronic implants. Wireless and battery‐free ultrasound‐based devices for healthcare monitoring comprise a piezoelectric element for the powering and communication, and a variable shunt load that varies according to a physiological parameter of interest. The changes in the load modify the acoustic reflectivity of the piezoelectric element, which can be detected using a pulse‐echo protocol. In the present study, the use of graphene solution‐gated field‐effect transistor is introduced as a new type of shunt load. Using an mm‐sized device, it is shown that the amplitude of an ultrasonic wave that reflects on the piezoelectric component is modulated by the voltage applied on the gate of the transistor both in physiological medium and biological tissue. This study sets the basis toward a new type of ultrasound‐based wireless and battery‐free biosensors.

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“…They have high spatial resolution (0.05–0.5) and fast temporal resolution [ 37 ]. These implants carry high risks of infection and biological rejection and have long term signal loss [ 49 , 56 ]. Early systems to enhance vision used sixty-eight electrodes implanted on the surface of the brain to enable improved vision [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

Identifying Thematics in a Brain‐Computer Interface Research

Alharbi

2023

Computational Intelligence and Neuroscience

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This umbrella review is motivated to understand the shift in research themes on brain-computer interfacing (BCI) and it determined that a shift away from themes that focus on medical advancement and system development to applications that included education, marketing, gaming, safety, and security has occurred. The background of this review examined aspects of BCI categorisation, neuroimaging methods, brain control signal classification, applications, and ethics. The specific area of BCI software and hardware development was not examined. A search using One Search was undertaken and 92 BCI reviews were selected for inclusion. Publication demographics indicate the average number of authors on review papers considered was 4.2 ± 1.8. The results also indicate a rapid increase in the number of BCI reviews from 2003, with only three reviews before that period, two in 1972, and one in 1996. While BCI authors were predominantly Euro-American in early reviews, this shifted to a more global authorship, which China dominated by 2020–2022. The review revealed six disciplines associated with BCI systems: life sciences and biomedicine (n = 42), neurosciences and neurology (n = 35), and rehabilitation (n = 20); (2) the second domain centred on the theme of functionality: computer science (n = 20), engineering (n = 28) and technology (n = 38). There was a thematic shift from understanding brain function and modes of interfacing BCI systems to more applied research novel areas of research-identified surround artificial intelligence, including machine learning, pre-processing, and deep learning. As BCI systems become more invasive in the lives of “normal” individuals, it is expected that there will be a refocus and thematic shift towards increased research into ethical issues and the need for legal oversight in BCI application.

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Large Animal Studies to Reduce the Foreign Body Reaction in Brain–Computer Interfaces: A Systematic Review

Cited by 4 publications

References 66 publications

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Graphene Solution‐Gated Field‐Effect Transistor for Ultrasound‐Based Wireless and Battery‐Free Biosensing

Identifying Thematics in a Brain‐Computer Interface Research

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