Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Lang, Yiran; Tang, Rongyu; Liu, Yafei; Xi, Pengcheng; Liu, Honghao; Quan, Zhenzhen; Song, Da; Lv, Xiaodong; Huang, Qiang; He, Jiping

doi:10.3390/bios11120503

Cited by 4 publications

(4 citation statements)

References 62 publications

(66 reference statements)

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“…The EIS of the implantable electrode tube showed good AC impedance characteristics, and was able to collect neural signals and conduct a current. On-bench system characterization provided evidence that the system had an excellent detection capability for weak signals compared to [29] and high current measurement accuracy for shunt-current quantization. The customized compact circuit was capable of measuring dual-channel iEEG signals with a relatively low noise floor, the shunt-current intensity was adjustable, and the current conduction path for current conduction treatment of epilepsy was investigated and validated with a short-term animal experiment.…”

Section: Discussionmentioning

confidence: 99%

An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment

et al. 2022

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This paper proposes a compact bioelectronics sensing platform, including a multi-channel electrode, intracranial electroencephalogram (iEEG) recorder, adjustable galvanometer, and shunt-current conduction circuit pathway. The developed implantable electrode made of polyurethane-insulated stainless-steel materials is capable of recording iEEG signals and shunt-current conduction. The electrochemical impedance of the conduction, ground/reference, and working electrode were characterized in phosphate buffer saline solution, revealing in vitro results of 517.2 Ω@1 kHz (length of 0.1 mm, diameter of 0.8 mm), 1.374 kΩ@1 kHz (length of 0.3 mm, diameter of 0.1 mm), and 3.188 kΩ@1 kHz (length of 0.1 mm, diameter of 0.1 mm), respectively. On-bench measurement of the system revealed that the input noise of the system is less than 2 μVrms, the signal frequency bandwidth range is 1 Hz~10 kHz, and the shunt-current detection range is 0.1~3000 μA with an accuracy of above 99.985%. The electrode was implanted in the CA1 region of the right hippocampus of rats for the in vivo experiments. Kainic acid (KA)-induced seizures were detected through iEEG monitoring, and the induced shunt-current was successfully measured and conducted out of the brain through the designed circuit-body path, which verifies the potential of current conduction for the treatment of epilepsy.

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Section: Discussionmentioning

confidence: 99%

An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment

et al. 2022

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“…Single-cell sequencing has enabled detailed molecular comparisons of neuronal classes in the spinal cord within and across species (Häring et al, 2018;Sathyamurthy et al, 2018;Delile et al, 2019;Shafer, 2019;Russ et al, 2021). It is now possible to record hundreds of neurons in an actively-moving animal, empowering us to validate and extend findings which previously could only be made in an isolated spinal cord (Long and Lee, 2012;Lang et al, 2021). We can also now take advantage of the vast anatomical and physiological knowledge of spinal neuron function in simpler organisms, in which they have been more comprehensively studied (Grillner and El Manira, 2020), to make novel predictions about their role in more complex ones.…”

Section: Cross-species Approach To Study Spinal Circuit Scalingmentioning

confidence: 94%

Spinal cords: Symphonies of interneurons across species

Wilson

Sweeney

2023

Front. Neural Circuits

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Vertebrate movement is orchestrated by spinal inter- and motor neurons that, together with sensory and cognitive input, produce dynamic motor behaviors. These behaviors vary from the simple undulatory swimming of fish and larval aquatic species to the highly coordinated running, reaching and grasping of mice, humans and other mammals. This variation raises the fundamental question of how spinal circuits have changed in register with motor behavior. In simple, undulatory fish, exemplified by the lamprey, two broad classes of interneurons shape motor neuron output: ipsilateral-projecting excitatory neurons, and commissural-projecting inhibitory neurons. An additional class of ipsilateral inhibitory neurons is required to generate escape swim behavior in larval zebrafish and tadpoles. In limbed vertebrates, a more complex spinal neuron composition is observed. In this review, we provide evidence that movement elaboration correlates with an increase and specialization of these three basic interneuron types into molecularly, anatomically, and functionally distinct subpopulations. We summarize recent work linking neuron types to movement-pattern generation across fish, amphibians, reptiles, birds and mammals.

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“…For gait analysis, the rats were trained to bipedally walk on a homemade treadmill for the first 2 weeks (Fig. 1 A, 5 to 6 d/week, 30 min/d) [ 40 ]. After the rats completed the training, their hindlimb motion was recorded using the motion capture system.…”

Section: Methodsmentioning

confidence: 99%

Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis

Xi,

Yao,

Liu

et al. 2024

Cyborg Bionic Syst

Self Cite

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Peripheral nerve stimulation is an effective neuromodulation method in patients with lower extremity movement disorders caused by stroke, spinal cord injury, or other diseases. However, most current studies on rehabilitation using sciatic nerve stimulation focus solely on ankle motor regulation through stimulation of common peroneal and tibial nerves. Using the electrical nerve stimulation method, we here achieved muscle control via different sciatic nerve branches to facilitate the regulation of lower limb movements during stepping and standing. A map of relationships between muscles and nerve segments was established to artificially activate specific nerve fibers with the biomimetic stimulation waveform. Then, characteristic curves depicting the relationship between neural electrical stimulation intensity and joint control were established. Finally, by testing the selected stimulation parameters in anesthetized rats, we confirmed that single-cathode extraneural electrical stimulation could activate combined movements to promote lower limb movements. Thus, this method is effective and reliable for use in treatment for improving and rehabilitating lower limb motor dysfunction.

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Multisite Simultaneous Neural Recording of Motor Pathway in Free-Moving Rats

Cited by 4 publications

References 62 publications

An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment

An iEEG Recording and Adjustable Shunt-Current Conduction Platform for Epilepsy Treatment

Spinal cords: Symphonies of interneurons across species

Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis

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