Graphene Solution‐Gated Field‐Effect Transistor for Ultrasound‐Based Wireless and Battery‐Free Biosensing
Sahil Sharma,
Carole‐Anne Lernoud,
Bruno Fain
et al.
Abstract:The development of wireless and battery‐free sensors for biomedical applications is a fast growing research and industrial field. It promises to greatly improve the patient's comfort during the diagnosis phase, but also in the treatment of chronic diseases. While the standard technologies are based so far on electromagnetic waves, ultrasonic powering and communication is offering perspectives to further reduce the size of the sensor in order to develop minimally invasive electronic implants. Wireless and batte… Show more
“…Carriers in graphene can be driven without the need to connect the metal electrodes directly to graphene. Such wireless graphene sensors are useful for wearable devices, continuous monitoring, and energy-saving sensor operation [213][214][215][216][217][218][219][220]. For example, wireless carrier transfer through a surface acoustic wave (SAW) has been demonstrated (Figure 8) [221][222][223].…”
Section: Multifaceted Evaluation Of Measurement Systems By Combining ...mentioning
Owing to its outstanding physical properties, graphene has attracted attention as a promising biosensor material. Field-effect-transistor (FET)-based biosensors are particularly promising because of their high sensitivity that is achieved through the high carrier mobility of graphene. However, graphene-FET biosensors have not yet reached widespread practical applications owing to several problems. In this review, the authors focus on graphene-FET biosensors and discuss their advantages, the challenges to their development, and the solutions to the challenges. The problem of Debye screening, in which the surface charges of the detection target are shielded and undetectable, can be solved by using small-molecule receptors and their deformations and by using enzyme reaction products. To address the complexity of sample components and the detection mechanisms of graphene-FET biosensors, the authors outline measures against nonspecific adsorption and the remaining problems related to the detection mechanism itself. The authors also introduce a solution with which the molecular species that can reach the sensor surfaces are limited. Finally, the authors present multifaceted approaches to the sensor surfaces that provide much information to corroborate the results of electrical measurements. The measures and solutions introduced bring us closer to the practical realization of stable biosensors utilizing the superior characteristics of graphene.
“…Carriers in graphene can be driven without the need to connect the metal electrodes directly to graphene. Such wireless graphene sensors are useful for wearable devices, continuous monitoring, and energy-saving sensor operation [213][214][215][216][217][218][219][220]. For example, wireless carrier transfer through a surface acoustic wave (SAW) has been demonstrated (Figure 8) [221][222][223].…”
Section: Multifaceted Evaluation Of Measurement Systems By Combining ...mentioning
Owing to its outstanding physical properties, graphene has attracted attention as a promising biosensor material. Field-effect-transistor (FET)-based biosensors are particularly promising because of their high sensitivity that is achieved through the high carrier mobility of graphene. However, graphene-FET biosensors have not yet reached widespread practical applications owing to several problems. In this review, the authors focus on graphene-FET biosensors and discuss their advantages, the challenges to their development, and the solutions to the challenges. The problem of Debye screening, in which the surface charges of the detection target are shielded and undetectable, can be solved by using small-molecule receptors and their deformations and by using enzyme reaction products. To address the complexity of sample components and the detection mechanisms of graphene-FET biosensors, the authors outline measures against nonspecific adsorption and the remaining problems related to the detection mechanism itself. The authors also introduce a solution with which the molecular species that can reach the sensor surfaces are limited. Finally, the authors present multifaceted approaches to the sensor surfaces that provide much information to corroborate the results of electrical measurements. The measures and solutions introduced bring us closer to the practical realization of stable biosensors utilizing the superior characteristics of graphene.
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