Laportea decumana (Robx) Wedd. Herbal Endemic Potential from Indonesia: A Literature Review

Thalib, Abdul; Masadah, Rina; Prihartono, Prihartono; Hamid, Firdaus; Hasan, Hulan; Keliwawa, Sudin; Labulawa, Irman

doi:10.3889/oamjms.2021.7759

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…The present study discovered that Laportea decumana leaves contain an active compound known as 9-(buta-1,3-dien-2-yl)-11-hydroxy-2,2a,2b,3,4,5,6,6a,7,8,8a1,9,9a,12,12a,14b-hexadecahydro-1H,11H,14H-13-oxacyclobuta [1,5] cyclopenta [1,2a]cyclobuta[de]cyclopropa[b]chrysen-14-one (MCI). The compound has antibacterial activity against S. aureus, free radical scavenging activity, and cytotoxic activity on 4T1 breast cancer cells.…”

Section: Discussionmentioning

confidence: 70%

“…It is widely grown in Papua and Papua New Guinea and has been used as a herbal remedy to treat pain and headaches. 1 It has potential pharmacological activity due to the presence of alkaloid, glycoside, and triterpenoid contents. 2 Previous studies found that L. decumana extract has analgesic and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

“…The 2D-NMR spectrums, which included HMQC and HMBC, were used as complementary data to interpret the chemical structure, which revealed a correlation (Table2). The spectroscopy scanning data ware combined to form the structure known as 9-(buta-1,3-dien-2-yl)-11hydroxy-2,2a,2b,3,4,5,6,6a,7,8,8a1,9,9a,12,12a,14b-hexadecahydro-1H,11H,14H-13-oxacyclobuta[1,5]-11-hydroxy ,2a,2b,3,4,5,6,6a,7,8,8a1,9,9a,12,12a,14b-hex cyclopenta[1,2-a] © 2022 the authors. This work is licensed under the Creative Commons Attribution 4.0 International License cyclobuta[de] cyclopropa [b]…”

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confidence: 99%

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Isolation and Evaluation of Pharmacological Activities of a Bioactive Hydroxylated C28 Steroid from the Leaf of Laportea decumana (Roxb.) Wedd

2022

TJNPR

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Materials and Methods Sources of chemicalsSilica gel F254, Silica gel 60 PF254 containing gypsum, dimethyl sulfoxide (DMSO), methanol, chloroform, n-hexane, and ethyl acetate were obtained from Merck, United States. Dextrose, nutrient agar (NA), and Mueller Hinton were purchased from Oxoid, United Kingdom. RPMI 1640, fetal bovine serum, penicillin, streptomycin, fungizone, sodium bicarbonate, and L-glutamine were supplied by Gibco, United States. HEPES (4-[2-hydroxyethyl]-1piperazineethanesulfonic acid) were purchased from Invitrogen, United States. DPPH (2,2-diphenyl-1-picrylhydrazyl) and MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) were obtained from Sigma-Aldrich, United Statesμ.

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Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Isolation and Evaluation of Pharmacological Activities of a Bioactive Hydroxylated C28 Steroid from the Leaf of Laportea decumana (Roxb.) Wedd

2022

TJNPR

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“…One of them is the Laportea decumana (Roxb.) Wedd (Thalib et al, 2021) in Figure 1, was known as a native Papuan plant (Simaremare et al, 2022). Papuans have utilized itchy leaves as a painkiller, which they have been using for generations (Simaremare et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Optimization of PEG 400 and PEG 6000 in Simplicia Ointment of Laportea decumana (Roxb.) Wedd

Dwi Ramadani

2023

IJALSR

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Introduction: The Papuan people have utilized the native herb Laportea decumana (Roxb.) Wedd for centuries to treat aches and pains. L. decumana is used by attaching leaves to the body area affected by the illness. Methods:This study aimed to test the optimal composition of PEG 400 and PEG 6000 in the L. decumana simplicia ointment formula to produce a good physical quality ointment. This study employed three formula designs made up of a mixture of PEG 400 (A) and PEG 6000 (B) in ratios of 65%:35%, 50%:50%, and 35%:65%, respectively, using the simplex lattice design approach. Physical qualities of the created ointment, such as organoleptic, homogeneous, miscibility, stickiness, pH, and acceptability tests, were performed on it. Next, the results of the physical properties test and response calculated were used to obtain the optimum formula. The one-sample T-test with a 95% confidence level was used to compare the experimental findings of the optimal formulation ointment with the results expected by the optimization approach. Result: The results indicated that the optimum composition was PEG 400: PEG 6000 by 60%: 40% which physical quality of 3.63 cm; pH 9.2 test, and a stickiness of 7.5 seconds. The results of the one-sample T-test showed that there was a nonsignificant difference between the experimental results and the predicted p>0.05. Conclusion: The ointment for itchy leaves can be formulated with a specific composition and has good physical quality.

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“…Natural therapy has been utilized since long ago, where the knowledge is obtained through generations so that it is known as traditional medicine in the community for local wisdom [1]. Nowadays, most of the world's population still relies on traditional medicines for healthcare purposes.…”

Section: Introductionmentioning

confidence: 99%

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

Dirgantara

Insanu

Fidrianny

2022

Open Access Maced J Med Sci

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BACKGROUND: The Myrmecodia genus belongs to the Rubiaceae family, which has the characteristic of an epiphytic plant. This genus spread from Malaysia, through the Philippines, Sumatra, Borneo, Java, New Guinea (Papua), Cape York to the Solomon Islands and Pacific region. It has been empirically proven to treat gout, inflammation, muscle pain relief, strengthen the body’s immunity, and cancer treatment. AIM: This article reviewed the scientific work about the Myrmecodia genus concerning their traditional uses, phytochemical compounds, and pharmacological activities of Myrmecodia. METHODS: The sources were from the scientific literature online database, including Science Direct, PubMed, and Google Scholar between 1978 and 2021. Furthermore, 112 articles were collected, while 61 full-text were assessed for eligibility. RESULTS: The Myrmecodia extract has many pharmacological activities, namely antioxidant, antibacterial, cytotoxic, and anticancer. CONCLUSION: Moreover, this review may be used as scientific literature for the next investigations on the genus Myrmecodia, especially regarding pharmacological properties such as in vitro and in vivo studies and isolation of the active compounds.

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Laportea decumana (Robx) Wedd. Herbal Endemic Potential from Indonesia: A Literature Review

Cited by 6 publications

References 13 publications

Isolation and Evaluation of Pharmacological Activities of a Bioactive Hydroxylated C28 Steroid from the Leaf of Laportea decumana (Roxb.) Wedd

Isolation and Evaluation of Pharmacological Activities of a Bioactive Hydroxylated C28 Steroid from the Leaf of Laportea decumana (Roxb.) Wedd

Optimization of PEG 400 and PEG 6000 in Simplicia Ointment of Laportea decumana (Roxb.) Wedd

Medicinal Properties of Ant Nest Plant (Myrmecodia Genus): A Comprehensive Review

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