BACKGROUND/OBJECTIVESOverproduction of nitric oxide (NO) by the inducible nitric oxide synthase (iNOS) enzyme can cause inflammation. Cyclooxygenase-2 (COX-2) is also involved in the inflammatory response through regulation of nuclear factor-kappa B (NF-κB). Areca catechu is one of the known fruit plants of the Palmaceae family. It has been used for a long time as a source of herbal medicine in Indonesia. In this study, we explored the effect of Indonesian Areca catechu leaf ethanol extract (ACE) in lipopolysaccharide (LPS)-induced inflammation and carrageenan-induced paw edema models. Recently, this natural extract has been in the spotlight because of its efficacy and limited or no toxic side effects. However, the mechanism underlying its anti-inflammatory effect remains to be elucidated.MATERIALS/METHODSWe measured NO production by using the Griess reagent, and determined the expression levels of inflammation-related proteins, such as iNOS, COX2, and NF-κB, by western blot. To confirm the effect of ACE in vivo, we used the carrageenan-induced paw edema model.RESULTSCompared to untreated cells, LPS-stimulated RAW 264.7 cells treated with ACE showed reduced NO generation and reduced iNOS and COX-2 expression. We found that the acute inflammatory response was significantly reduced by ACE in the carrageenan-induced paw edema model.CONCLUSIONTaken together, these results suggest that ACE can inhibit inflammation and modulate NO generation via downregulation of iNOS levels and NF-κB signaling in vitro and in vivo. ACE may have a potential medical benefit as an anti-inflammation agent.
Kampung WulukubunArso XIV, Distrik Skanto Kabupaten Kerombanyak ditumbuhi daun gatal yang bermanfaat sebagai obat tradisional sebagai antinyeri, mengurangi rasa capek, dan mengurangi pegal-pegal. Daun gatal banyak terdapat di kampung tapi sering sekali hanya dibiarkan kering, layu, mati, bahkan dibuang. Padahal nilai dari daun ini sangat besar jika dikembangkan tidak hanya lembaran daun gatal tetapi sebagai produk farmasi. Tujuan dari kegiatan ini adalah melakukan sosialisasi dan membuat sediaan topikal salep daun gatal di kampung Wulukubun Arso XIV Kabupaten Keerom Papua. Kegiatan ini dilaksanakan dengan melakukan persiapan di kampus/ administrasi, menjalin kerjasama dengan mitra, instansi terkait, kegiatan hari H di kampung, evaluasi, laporan, dan publikasi. Hasil yang diperoleh dari kegiatan ini adalah 7,4% peserta pernah mengikuti kegiatan yang sama. Sebanyak 88,9% peserta memperoleh manfaat dari kegiatan ini dan 70,4% berkomitmen akan membantu orang lain dalam menyebarluaskan informasi penting yang mereka dapat pada waktu kegiatan ini.
Sarang semut plant is one of indigenous medicinal plants of Merauke region, the Papua province. Local people use the bulb of sarang semut plants to cure inflammation, muscle pain and enhancing immunity. However rare research of the plants has been done especially on the antioxidant activity. The objective of this research was to investigate the antioxidant activity of three species of sarang semut plants which were Myrmecodia beccarii, Myrmecodia sp. and Hydnophytum sp. The test was necessary to identify the inhibitory concentration level of plant extract in blocking a free radical (IC50). Parts of plants were extracted with maceration using methanol for 3 x 24 h to produce concentrated methanol. Plant extracts of three species were then subject to antioxidant activity test based on free radical blocking of 1,1-Difenil-2-Pikrilhidrazil (DPPH) qualitatively and quantitatively using Ultraviolet-Visible spectrophotometry. The results showed the methanol extract of M. beccarii, Myrmecodia sp. and Hydnophytum sp. were active as antioxidants with IC50 from 8.18 ppm, 21.79 ppm, 25.31 ppm, respectively while Vitamin C as a control has IC50 7.85 ppm. In conclusion, three plant species of sarangsemut are potential as natural antioxidant and plant extracts of M. beccarii showed the highest antioxidant activity among others. Key words: Antioxidant, sarang semut plants, Rubiaceae, DPPH.
ABSTRAK Tekanan darah tinggi, diabetes mellitus (DM),
BACKGROUND: The Myrmecodia genus belongs to the Rubiaceae family, which has the characteristic of an epiphytic plant. This genus spread from Malaysia, through the Philippines, Sumatra, Borneo, Java, New Guinea (Papua), Cape York to the Solomon Islands and Pacific region. It has been empirically proven to treat gout, inflammation, muscle pain relief, strengthen the body’s immunity, and cancer treatment. AIM: This article reviewed the scientific work about the Myrmecodia genus concerning their traditional uses, phytochemical compounds, and pharmacological activities of Myrmecodia. METHODS: The sources were from the scientific literature online database, including Science Direct, PubMed, and Google Scholar between 1978 and 2021. Furthermore, 112 articles were collected, while 61 full-text were assessed for eligibility. RESULTS: The Myrmecodia extract has many pharmacological activities, namely antioxidant, antibacterial, cytotoxic, and anticancer. CONCLUSION: Moreover, this review may be used as scientific literature for the next investigations on the genus Myrmecodia, especially regarding pharmacological properties such as in vitro and in vivo studies and isolation of the active compounds.
Tuberkulosis (TB), tekanan darah tinggi, diabetes mellitus (DM), asam urat, dan kolesterol merupakan penyakit yang semakin lama namun pasti akan menyebabkan kesakitan yang tidak tertahankan bahkan menimbulkan kematian pada penderita. Kegiatan ini dilakukan sebagai salah satu bentuk kepedulian kampus untuk mendukung pemerintah dalam upaya kampanye kesehatan, terutama pada masyarakat di Kampung Yapase. Kegiatan ini dilakukan dengan ceramah dan edukasi mengenai pencegahan penyakit TiDAK (tuberkulosis, diabetes melitus, asam urat, dan kolesterol) dengan beberapa tahap yaitu dengan: 1). Pembuatan buku saku; 2). Sosiaisasi buku TiDAK; 3). Evaluasi kegiatan. Kegiatan ini diselenggarakan pada hari kamis tanggal 3 Agustus 2017. Lokasi kegiatan dilakukan di Aula Desa Yapase. Jumlah peserta sebanyak 21 orang. Dari hasil kegiatan didapati 57% masyarakat tidak tahu bagaimana pencegahan dan pengobatan baik TB, DM, asam urat, dan kolesterol ini dan hanya 52% peserta pernah mengikuti kegiatan yang sama. 64% peserta memahami bagaimana pencegahan dan pengobatan penyakit TiDAK dan 95% berkomitmen akan membantu orang lain dalam menyebarluaskan informasi penting yang mereka dapat pada waktu kegiatan.Kata kunci: Tuberkulosis (TB), Diabetes, Asam urat, Kolesterol, Yapase
The use of herbs fo treatment, especially the use of medicines that have been integrated into formal health services in Indonesia is still low compared to some other Asian countries. Papuan medicinal plants have superior characteristic that are different from other provinces in Indonesia. The usage of potential natural products as medicines for Papuan communities are selected by a good understanding of herbal medicine. The potential of biological acticity from natural resources provides a great opportunity to developing this program. In this case, the activities of the Community Engagement activities with the title Training Program to Produced of Crude Material for Herbs and Analyze of Traditional Medicine for Mothers in Waena Public Health of Jayapura City ; secondly practicing how to analyze the product of traditional medicine; the third produces an output in the form of local and national community engagement journals. The methods used in the implementation of this activity are lectures, simulations or demonstrations as well as the direct practice of manufacturing products from indigenous plant drugs Papua. The conclusion that tarticipants are very enthusiastic to follow the activity of service and can know the development the program, Based on the evaluation result indicates that the participants have satisfaction level is high when viewed from percentage of all aspect.Keywords: crude material, traditional medicine, analyze, public health
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