Laparoscopic Management of Early-Stage Malignant Nonepithelial Ovarian Tumors

Shim, Seung‐Hyuk; Kim, Dae-Yeon; Lee, Shin-Wha; Kim, Jong-Hyeok; Kim, Yong‐Man; Kim, Young‐Tak; Nam, Joo‐Hyun

doi:10.1097/igc.0b013e318272e754

Cited by 41 publications

(20 citation statements)

References 22 publications

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“…Laparotomy has traditionally been performed, but if tumor rupture can be avoided and complete staging can be performed, the use of minimally invasive surgery appears to be feasible, although there is currently a paucity of data. 15 Because these tumors most often present in patients of reproductive age, there must be an emphasis on fertility preservation. Fertility-sparing surgery appears to be safe with excellent survival after long-term follow-up, yielding outcomes equivalent to patients undergoing hysterectomy with bilateral salpingo-oophorectomy.…”

Section: Surgical Management and Fertility Preservationmentioning

confidence: 99%

Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors

Brown¹,

Friedlander

Backes

et al. 2014

Int J Gynecol Cancer

129

112

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Most women diagnosed with malignant ovarian germ cell tumors have curable disease and experience excellent survival with manageable treatment-associated morbidity, related both to tumor biology and improvements in treatment over the last 4 decades. Malignant ovarian germ cell tumors occur predominantly in girls, adolescents, and young women and are often unilateral tumors of early stage, although advanced-stage disease occurs in approximately 30% of patients. Tumors are usually chemosensitive, thereby allowing fertility-sparing surgery in most women with high chance of cure. Differences in practice do exist among providers in various subspecialties and geographic areas. In most settings, collaborative efforts among specialties allow the optimal treatment of women with these rare tumors, and implementation of standard guidelines at an international level should translate to effective clinical trial design, rapid accrual to clinical trials, and universally improved patient outcomes. This consensus guideline represents a summary of recommendations for diagnosis and management that has been agreed upon by cooperative groups worldwide. It builds upon individual publications including previously published summary documents and provides the most current practice standards validated worldwide.

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Section: Surgical Management and Fertility Preservationmentioning

confidence: 99%

Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors

Brown¹,

Friedlander

Backes

et al. 2014

Int J Gynecol Cancer

129

112

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“…The sex cord stromal tumors are most of the time low grade and present generally in younger patients than ovarian epithelial malignancies [1]. They encompass a heterogeneous group of neoplasms containing variety of cells which are derived from gonadal sex cords or stromal cells [2]. Because of the smaller size, lower grade of malignancy and the rarity of these tumors, they are often diagnosed by pathology following surgery [3].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years’ retrospective study in a developing country

et al. 2013

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BackgroundOvarian sex cord stromal tumors are rare neoplasms as compared to epithelial tumors. No large study has been done in Pakistan to find out the frequencies of various sex cord stromal tumors and their clinicopathological behavior in our region. The purpose of our study was to determine the various histological patterns and clinical features of ovarian sex cord stromal tumors along with follow-up in our set-up.MethodsIt is a retrospective observational study. The study was conducted in section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan. All reported cases of sex cord stromal tumors of ovary during 1992 to 2012 were retrieved. The retrieved slides were reviewed and patient demographics, clinical and pathological features were noted on proforma. SPSS Statistics Version 19 was used for all analyses. Data is expressed as absolute values and percentage or as mean ± standard deviation (SD).ResultsA total of 480 cases of sex cord stromal tumors were retrieved. The median age was 45 years. Bilaterality was observed in 4 cases. Of the different subtypes of sex-cord stromal tumors, most common was adult granulosa cell tumor 211(43.9%). 24 Juvenile granulosa cell tumors were retrieved (5%). Other types were fibromas 98 (20.4%) fibrothecomas 47(9.8%), thecomas 26(5.4%), sertoli-leydig cell tumors 34(7%), sclerosing stromal tumors 26 (5.4%), steroid cell tumors (10) and 4 cases of sex cord tumor with annular tubules. Of various immunohistochemical stains applied, Inhibin was frequently positive in all subtypes and focal cytokeratins were also seen commonly. Follow up information was available in 305 cases and out of these only 16 (5%) developed recurrence or metastasis.ConclusionsSex cord stromal tumors are uncommon ovarian tumors in Pakistani population, with wide age range and diverse histological types having good prognosis. Immunohistochemical markers overlap with epithelial tumors so there is need to distinguish these two.

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“…Adult granulosa cell tumors are characterized by slow growth with an indolent course; however, recurrences are possible even after more than one decade (3). It is evident that patients with this tumor have recurrent disease, which typically is the eventual cause of death (4,5). For this reason, prolonged follow-up is necessary.…”

mentioning

confidence: 99%

“…For this reason, prolonged follow-up is necessary. Due to the rarity of adult granulosa cell tumors, the prognostic factors of tumor recurrence are uncertain, although some clinical and pathological parameters, such as advanced stage at the time of initial diagnosis, larger tumor size, higher mitotic index, tumor rupture, and presence of residual tumor after initial surgery, have been reported to be associated with a higher risk of recurrence (4,5). The pathogenesis and cellular pathways that regulate cellular proliferation and survival of adult granulosa cell tumors remain poorly understood.…”

mentioning

confidence: 99%

Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary

Sung

Kim

2017

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Laparoscopic Management of Early-Stage Malignant Nonepithelial Ovarian Tumors

Abstract: This is the first case series report of laparoscopic surgery for MNEOTs. Laparoscopic management seems feasible and safe without compromising survival. With additional evidence, laparoscopic surgery could be a safe therapeutic option for management of early-stage MNEOTs.

Cited by 41 publications

References 22 publications

Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors

Gynecologic Cancer Intergroup (GCIG) Consensus Review for Ovarian Germ Cell Tumors

Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years’ retrospective study in a developing country

Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary

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