Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years’ retrospective study in a developing country

Haroon, Saroona; Zia, Aleena; Idrees, Romana; Memon, Aisha; Fatima, Saira; Kayani, Naila

doi:10.1186/1757-2215-6-87

Cited by 46 publications

(46 citation statements)

References 25 publications

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“…This is in accordance with the available international literature. [6][7][8][9] The histomorphological observations in our study are similar to other reports. 6,7 We observed that most of the tumors were unilateral, ranging from 5 to 15 cm in size.…”

Section: Resultssupporting

confidence: 91%

“…This is slightly lower as compared to other studies. 6,7 The most common clinical presentation in our study was abdominal pain and lump, whereas the signs and symptoms of hormonal excess such as virilization and precocious puberty and menstrual irregularities were relatively less. This is in accordance with the available international literature.…”

Section: Resultsmentioning

confidence: 68%

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Ovarian sex cord stromal tumors: an institutional experience

Bhargava

Vyas

Bhargava

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Sex cord stromal tumors are a heterogeneous group of rare neoplasms of ovary. These tumors arise from different cells of the ovary and have a fascinating variety of clinical presentations. They are mostly diagnosed on histopathology after surgical removal.Methods: Our study aims at discussing the clinical and histomorphological spectrum of these rare tumors at a tertiary care centre.Results: In our study 158 ovarian sex cord stromal tumors were received over a period of eight years at our institute. Out of these, the most common age group was 30 to 40 years and the chief complaint was abdominal pain and lump in majority of cases. Most common tumor histologically was Adult Granulosa cell tumor (42.4%). There were 8 (5.1%) Juvenile granulosa cell tumors, 31 (19.6%) fibromas, 6 (3.8%) thecomas, 14 (8.9%) fibrothecomas, 24 (15.2%) sertoli leydig cell tumors and 7 (4.4%) sclerosing stromal tumors. We encountered one case of sex cord tumor with annular tubules.Conclusions: Sex cord stromal tumors are uncommon ovarian tumors in Indians but have a wide range of distribution of age, clinical features and histopathological types. Since most of these have a relatively good prognosis, a high index of suspicion and thorough knowledge of clinicopathological findings is important for correct diagnosis and appropriate treatment.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 68%

Ovarian sex cord stromal tumors: an institutional experience

Bhargava

Vyas

Bhargava

2017

Int J Reprod Contracept Obstet Gynecol

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“…In mucinous cystadenocarcinoma (0.5%), the atypical cells were also seen invading the ovarian stroma. Ovarian sex cord-stromal tumors are uncommon neoplasms that represent approximately 7% of 25 all ovarian tumors. Only single case of fibroma as well as a single case of fibroma-thecoma was found in our study.…”

Section: Singh M Et Almentioning

confidence: 99%

Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of Ovary : A 4 Year Study in Eastern Nepal

Singh

Jha

Kafle

et al. 2017

Birat J. Health Sci.

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IntroductionOvarian neoplastic and nontineoplastic lesions form a pelvic mass and cause gynaecological problems. Therefore, proper recognization and classification is important for appropriate therapy.ObjectiveTo study the morphological patiern and classify the neoplastic and nontineoplastic ovarian lesions in terms of age and size.MethodologyA retrospective study conducted at Sriram Diagnostic Clinic, Biratnagar, Nepal and Birat Medical College, Tankisinwari, Morang, Nepal during a period of March 2012 to February 2016. All abdominal hysterectomy specimens with bilateral or unilateral salpingo-oophorectomy and all ovarian surgeries presenting with either solid or cystic ovarian lesions were included in the study for histopathological analysis. Normal appearing ovaries on gross and microscopic examination were excluded from the study.ResultsA total of 522 cases were studied. Out of which 329 (63%) were non-neoplastic and 193 (37%) were neoplastic. Follicular cysts comprised of 112 (34%) cases, and it was the most common non neoplastic lesion. The age of patients with non-neoplastic lesions and neoplastic lesions varied from 16-54 years and 13-72 years respectively. Size of nonneoplastic and neoplastic lesions varied from 2-12 cm and 2- 19 cm respectively. Among the 193 neoplastic ovarian lesions, 181 (94 %) were benign, as well as 4 (2%) were borderline and 8 (4 %) were malignant. Mature cystic teratoma was the commonest benign tumor followed by Serous cystadenoma. Serous cystadenocarcinoma was the commonest occurring malignant tumor followed by Mucinouscystadenocarcinoma.ConclusionVarying types of both non neoplastic and neoplastic ovarian lesion were seen. Among the non-neoplastic and neoplastic lesion, the most commonly encountered lesion was follicular cyst and mature cystic teratoma respectively.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, Page: 168-174

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“…Son dönemlerde bunlara CD99, CD56 ve "Steroidenic factor (SF-1)", FOXL2 gibi immünohistokimyasal boyalar da ilave edilmektedir. 4,13 Seks kord stromal tümörle-rinin alt tipleri arasında immünohistokimyasal ekspresyon profilleri de örtüşmektedir.…”

Section: Discussionunclassified