Lanolin‐based organogels as a matrix for topical drug delivery

Sagiri, Sai S.; Behera, Beauty; Pal, Kunal; Basak, Piyali

doi:10.1002/app.38590

Cited by 32 publications

(31 citation statements)

References 51 publications

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“…The use of L2 and L3 organogels did not result in the formation of microparticles. This may be associated with the lower thermal stability of L2 and L3 organogels . In our previous study, we found that the L2 and L3 organogels were unstable when they were tested in a cyclic thermal test (−20–37°C).…”

Section: Resultsmentioning

confidence: 94%

“…The formation of organogel was predominantly influenced by the proportion of water. The stable organogels were formed when the lanolin : water proportion was maintained 2 : 1, 1 : 1, and 1 : 2 . Formation of organogels was checked by inverted tube method (Figure ) .…”

Section: Resultsmentioning

confidence: 99%

“…Lanolin based organogels were prepared as per the protocol published in our previous paper . In short, the organogels were prepared by varying the proportions of lanolin and water in the ratio of 2 : 1, 1 : 1 and 1 : 2.…”

Section: Methodsmentioning

confidence: 99%

“…Lanolin based formulations have been studied in topical and oral drug delivery . The organogels derived from lanolin have been found to be semi‐solid at RT (25°C) and stable for longer periods of time . Lanolin and lanolin based organogels were encapsulated within alginate microparticles by ionotropic internal gelation method.…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation of animal wax‐based organogels in alginate microparticles

Sagiri

Pal

Basak

2014

J of Applied Polymer Sci

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Encapsulation of organogels is a novel perspective in the field of controlled drug delivery. This study reports encapsulation of lanolin based organogels within alginate microparticles. The microparticles were prepared by emulsification/internal gelation method. Microscopic studies suggested spherical shape of the microparticles. Fourier transform infrared, X-ray diffraction and thermal studies confirmed the presence of organogels within the microparticles. Organogels containing microparticles showed improved drug (e.g., salicylic acid and metronidazole) entrapment efficiency. The release of the drugs from the microparticles was dependent on the pH of the dissolution medium. The release was diffusion mediated. The drug loaded microparticles showed antimicrobial activity against E. coli and B. subtilis. The preliminary study suggested that the encapsulation of the organogels may help prolonging the release of the drugs and hence may be tried as vehicles for controlled drug delivery. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014, 131, 40910.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Encapsulation of animal wax‐based organogels in alginate microparticles

Sagiri

Pal

Basak

2014

J of Applied Polymer Sci

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“…Drug release kinetics was studied using two different mathematical models viz., Higuchian model and KorsmeyerPeppas (KP) model (31).…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Genipin-Crosslinked Gelatin-Based Emulgels: an Insight into the Thermal, Mechanical, and Electrical Studies

et al. 2015

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Abstract. The present study discusses about the preparation and characterization (thermal, mechanical, and electrical) of the genipin-crosslinked gelatin emulgels. Emulgels have gained importance in recent years due to their improved stability than emulsions and ability to control the drug release. Mustard oil was used as the representative oil. A decrease in the enthalpy and entropy of the formulations was observed with the increase in the oil fraction. The mechanical studies suggested formation of softer emulgels as the oil fraction was increased. As the proportion of the oil fraction was increased in the emulgels, there was a corresponding increase in the impedance. The drug release properties from the emulgels were also studied. Ciprofloxacin was used as the model antimicrobial drug. The drug release was higher from the emulgels whose electrical conductivity was higher.

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Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

Pradhan

Sagiri

Singh

et al. 2013

J of Applied Polymer Sci

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This study has been designed to develop palm oil (PO) based organogels using span 80/tween 80 mixture (OG) as a gelator system by fluid-filled structure mechanism. The results suggested formation of organogels, emulsions, and microemulsions as the proportions of PO, OG and water were varied. The emulsions were found to be thermodynamically unstable as compared to the organogels and the microemulsions. Accelerated thermal stability test suggested that all the microemulsions and the organogels of only eight compositions were stable. The organogels showed viscoelastic property while the microemulsions showed viscous flow behavior. Both the organogels and the microemulsions were found to be highly hemocompatible and nonirritant. The antimicrobial efficiency of the ciprofloxacin HCl-loaded formulations showed equivalent efficiency as compared to marketed formulations. The rates of drug release from the organogels were found to be relatively slower as compared to the microemulsions. The preliminary studies suggested that the developed organogel and microemulsion-based formulations may be tried for topical delivery of antimicrobials.

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Lanolin‐based organogels as a matrix for topical drug delivery

Cited by 32 publications

References 51 publications

Encapsulation of animal wax‐based organogels in alginate microparticles

Encapsulation of animal wax‐based organogels in alginate microparticles

Genipin-Crosslinked Gelatin-Based Emulgels: an Insight into the Thermal, Mechanical, and Electrical Studies

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

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