Encapsulation of animal wax‐based organogels in alginate microparticles

Abstract

Encapsulation of organogels is a novel perspective in the field of controlled drug delivery. This study reports encapsulation of lanolin based organogels within alginate microparticles. The microparticles were prepared by emulsification/internal gelation method. Microscopic studies suggested spherical shape of the microparticles. Fourier transform infrared, X-ray diffraction and thermal studies confirmed the presence of organogels within the microparticles. Organogels containing microparticles showed improved drug (e.g., salicylic acid and metronidazole) entrapment efficiency. The release of the drugs from the microparticles was dependent on the pH of the dissolution medium. The release was diffusion mediated. The drug loaded microparticles showed antimicrobial activity against E. coli and B. subtilis. The preliminary study suggested that the encapsulation of the organogels may help prolonging the release of the drugs and hence may be tried as vehicles for controlled drug delivery. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014, 131, 40910.

Monoketonic Curcuminoid-Lidocaine Co-Deliver Using Thermosensitive Organogels: From Drug Synthesis to Epidermis Structural Studies

“…Measured pH values ranged from 5.2 to 6.3 for ORGs containing LDC and LEC, respectively. Such pH values were similar to other PL-based ORG systems containing lanolin, which were described to be adequate for skin application [11,37].…”

Development and characterization of gelatin‐based hydrogels, emulsion hydrogels, and bigels: A comparative study

“…The formulations were dried for 72 h (40°C) to convert the formulations into xerogels. The xerogels were sputter‐coated with platinum before analysis …”