Laminin and collagen IV in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: An immunohistochemical study

Félix, Ana; Rosa, José; Fonseca, Isabel; Cidadão, António; Soares, Jorge

doi:10.1016/s0046-8177(99)90251-4

Cited by 22 publications

(18 citation statements)

References 20 publications

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“…Pleomorphic adenoma has been investigated immunohistochemically (5)(6)(7)(8)(9)(10)(11)(12). Of particular interest is the fact that S-100 protein can be demonstrated in both epithelial and myoepithelial components.…”

Section: Pleomorphic Adenoma and Warthin's Tumorsmentioning

confidence: 99%

Selected Problems in Fine Needle Aspiration of Head and Neck Masses

Stanley

2002

Modern Pathology

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A wide variety of masses in the head and neck, including those in the major salivary glands, can be approached by fine needle aspiration. In many instances, a correct definitive diagnosis con be rendered after examination of smears or cell block material. However, several significant but uncommon areas can lead to diagnostic difficulties, with the potential for clinically important diagnostic errors. Many of these occur in salivary gland lesions. The most frequent problems involve variations in the expected cytology of pleomorphic adenoma. Then, there are several benign-malignant "look-alike" pairs of lesions. The first of these is related to smallcell epithelial neoplasms of low nuclear grade; the most frequent problem is between basal cell adenomas and adenoid cystic carcinoma, particularly the solid (anaplastic) type. The next area contrasts mucoepidermoid carcinoma with its cytologic mimic, benign salivary gland duct obstruction. The final difficulty in salivary gland aspiration contrasts large-cell epithelial lesions of low nuclear grade: oncocytic proliferations and acinic cell carcinoma. The clinical implications of cytologically benign squamous cell-containing cyst aspirates from the lateral neck will be discussed. Finally, a brief consideration of methodological optimization for thyroid aspirations will be offered. Mod Pathol 2002;15(3):342-350Masses in many head and neck sites are amenable to diagnosis by fine needle aspiration (FNA) cytology. After a brief consideration of general clinical principles of the method, this discussion will focus on areas in which significant diagnostic difficulties may arise. Several of these involve salivary gland sites and include the following: uncommon variations on the cytology of pleomorphic adenomas; the differential diagnosis of small blue cell epithelial neoplasms; salivary gland aspirates that yield mucinous cystic contents; neoplasms that consist of monotonous large cells with eosinophilic cytoplasm and low-grade nuclear features; and squamous-lined cysts of the lateral neck. Finally, we will briefly consider issues in thyroid aspiration. General Considerations in Fine Needle Aspiration of the Head and NeckThe diversity of masses in the head and neck and the differential diagnostic difficulties cited previously require that the best possible technique and preparations be employed. In general, the technique of needle aspiration is the same as that applied to other areas. We use 25-gauge (0.5-mm) needles exclusively. We have also found that a 10-mL syringe is quite adequate and that larger syringes do not produce better specimens. It is our practice to use a syringe holder in the Swedish manner, although others prefer the French technique of puncture without syringe aspiration. We have found that 25-gauge needles give adequate samples, and all of the cytologic material illustrated in this presentation was obtained with these small instruments.We regard the preparation of aspirated material as a key step in optimizing diagnosis. We have found that the best results...

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Section: Pleomorphic Adenoma and Warthin's Tumorsmentioning

confidence: 99%

Selected Problems in Fine Needle Aspiration of Head and Neck Masses

Stanley

2002

Modern Pathology

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“…Additionally, it was reported that laminin and collagen IV were involved in the process of malignant transformation of PA and biological progression [17]. Félix et al reported that basement components such as laminin and collagen IV detected at interstitial matrix of mixed tumors can be associated with overproduction and/or secretion of abnormal macromolecules by the neoplastic cells, impairing their ability for normal assembly [17]. The partial loss of co-localization of these two components at the interstitial matrix may be associated with pathological conditions, such as neoplasias [17].…”

Section: Discussionmentioning

confidence: 99%

Carcinoma ex pleomorphic adenoma in minor salivary glands of the anterior tongue: A case report

Yamada

Yanamoto

Rokutanda

et al. 2013

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathol

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“…Clinically, pleomorphic adenoma presents as a slow growing mass, firm on palpation, which is usually encapsulated and may ulcerate in some situations. It affects any age but is more frequent in adults aged 30 to 50 years, with a slight predominance among females (Felix et al, 1999;Louro et al, 2002). Histologically, the tumor is characterized by histomorphologic heterogeneity consisting of an epithelial component that forms ducts and cystic structures as well as cell clusters arranged in islands or nests, whereas the stroma can be mucoid, myxoid or chondroid depending on the product derived from the altered metabolism of epithelial cells (Matturri et al).…”

Section: Introductionmentioning

confidence: 99%

Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

Gordón-Núñez¹,

Godoy

Soares

et al. 2008

Int. J. Morphol.

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GORDÓN-NÚÑEZ SUMMARY:The aim of the study was to determine the immunohistochemical expression of the PCNA, p53 and bcl-2 proteins in pleomorphic adenomas. Nineteen specimens of pleomorphic adenomas were selected for analysis by the streptavidin-biotin-peroxidase method with antibodies against p53, PCNA and bcl-2 proteins. It was observed weak labeling for p53 in 12 cases (63.1%) and for PCNA in 8 (42.1%). With respect to the bcl-2 labeling index, no expression of this protein was detected in 12 cases, corresponding to 63.1% of the sample. Based on these findings, it was concluded that p53 and PCNA can favor the proliferative activity of pleomorphic adenomas, whereas bcl-2 probably does not effectively participate in the pathogenesis of this tumor.

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Laminin and collagen IV in pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: An immunohistochemical study

Cited by 22 publications

References 20 publications

Selected Problems in Fine Needle Aspiration of Head and Neck Masses

Selected Problems in Fine Needle Aspiration of Head and Neck Masses

Carcinoma ex pleomorphic adenoma in minor salivary glands of the anterior tongue: A case report

Inmunohistochemical Expression of PCNA, p53 and bcl-2 in Pleomorphic Adenomas

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