Laminaria Japonica Polysaccharides effectively inhibited the growth of nasopharyngeal carcinoma cells in vivo and in vitro study

Zeng, Manli; Wu, Xingyu; Li, Fen; She, Wensheng; Zhou, Lin; Pi, Benyuan; Xu, Zhinan; Huang, Xiaolin

doi:10.1016/j.etp.2017.03.005

Cited by 19 publications

(10 citation statements)

References 12 publications

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“…Numerous studies support the anti-cancer activities of fucoidan in vitro and in vivo, and effects of fucoidan on various cancers in humans have been proposed and demonstrated, here we summarize the results in Table 1. In brief, the anti-cancer effects of fucoidan have been evaluated in cancers such as acute leukemia [18], lymphoma [19, 20], head and neck cancer [21], nasopharyngeal carcinoma [22], oral cancer (or mucoepidermoid carcinoma) [23], esophageal cancer [24], lung cancer [25–27], breast cancer [28–30], gastric cancer [31], hepatoblastoma [32], hepatocellular carcinoma and hepatic cells [33], cholangiocarcinoma [32], prostate cancer [34], colorectal carcinoma [35, 36], renal cancer [32], ovarian cancer [32], cervical cancer [37], bladder cancer [38], and gallbladder cancer [32], among others.…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Hsu¹,

Hwang

2019

Clinical & Translational Med

108

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The chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l -fucose. Fucoidan has various biological and pharmacological activities, such as anti-cancer/anti-tumor, anti-proliferation, anti-inflammatory and immune-modulatory functions, and fucoidan-related dietary supplements and nutraceuticals have recently drawn considerable attention. In this review, we aim to provide a current view of different aspects of fucoidan biological activity, with a focus on the anti-cancer regulatory effects of fucoidan on growth signaling mechanisms. First, we discuss historical aspects of fucoidan and fucoidan products, as well as the anti-cancer effects of fucoidan on various cancer cells. Second, we discuss fucoidan’s biological activities and induction of cell death in cancer cells, including multiple mechanisms and signal transduction pathways related to its anti-cancer effects. Next, we focus on fucoidan and fucoidan-derived products that have been marketed as dietary supplements or nutraceuticals for cancer, including anti-cancer effects of fucoidan when combined as an adjuvant with clinical drugs. Finally, case studies of fucoidan in complementary therapy and as an alternative medicine in animal and mouse models and human clinical trials to alleviate side effects of anti-cancer chemotherapy are discussed. Combining fucoidan with clinical therapeutic agents in the treatment of cancer patients, dissecting the related signal transduction pathways and investigating their dynamic interactions may reveal potential molecular targets in cancer prevention, therapies and key obstacles in the current development of anti-cancer strategies.

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Section: Introductionmentioning

confidence: 99%

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Hsu¹,

Hwang

2019

Clinical & Translational Med

108

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“…According to the results, L. Japonica polysaccharide induced apoptosis in HeLa and U14 cells with IC 50 values of 85.74 and 76.91 μg/ mL, respectively. The nasopharyngeal carcinoma cells inhibitory effect of a polysaccharide separated from L. Japonica was recently documented by Zeng et al (2017). In this study, the authors demonstrated that the administration of 12.5-50 mg/kg polysaccharide had significant inhibitory effect on tumor growth (nasopharyngeal cancer cell transplanted BALB/C nude mouse).…”

Section: Anticancer Activitymentioning

confidence: 65%

“…(Choi et al, 2012;Islam et al, 2013). In addition, L. japonica use as a medicinal ingredient in traditional Japanese and Chinese medicine (anti-thrombosis, gall disease, hard lump, edema, anti-thyroid tumor, tuberculosis and beriberi drugs) to treat various disease conditions (Mei et al, 2017;Wang et al, 2018;Zeng et al, 2017). Sliced L. japonica (5-6 cm long strips) is boiled with hot water to prepare soup and dried L. japonica is used as a cookie with green tea, or pickled in vinegar.…”

Section: Sanjeewa Et Al Edible Brown Seaweeds: a Reviewmentioning

confidence: 99%

Edible brown seaweeds: a review

Sanjeewa¹,

Jeon²

2018

JFB

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Seaweeds play a vital role as a source of food and ingredients in traditional Korean medicine. Koreans consume seaweed as fresh vegetables, salad, soups, or snacks. There are several edible brown seaweed species are abundant along the shores of the Korean peninsula, such as Ecklonia cava, Hizikia fusiforme, Laminaria japonica, Pelvetia siliquosa, Sargassum fulvellum, and Undaria pinnatifida. With the growing body of scientific evidence, it is clear that these brown seaweeds are not only good substitutes for land vegetables but also a good source of bioactive secondary metabolites. The secondary metabolites identified from edible Korean brown seaweeds (phlorotannins, sulfated polysaccharides, pigments, and sterols) have the potential to be developed as functional food ingredients. However, seaweeds consumption and their industrial level applications as functional materials are limited compared to the land vegetables. Insufficient awareness about health benefits of seaweeds might be the reason for this issue. Thus, in this review health promotion properties associated with edible Korean brown seaweeds are summarized. The present study might therefore increase consumption and industrial use of brown seaweeds.

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“…Recent years have witnessed increasing attention of many plants due to their wide range of biological activities. Polysaccharides from Laminaria japonica have also been shown to possess a variety of biological functions, including antioxidation, antivirus, and tumor growth inhibition [4][5][6][7][8][9][10][11][12][13][14]. Therefore, we studied the human non-small-cell lung cancer A549 cells and discussed the effects of Laminaria japonica polysaccharides on its growth in vivo and vitro and its possible mechanism.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have found that Laminaria japonica polysaccharides have a variety of biological activities, including promoting fertility [4], alleviating metabolic syndrome [5], preventing vascular calcification [6], resisting virus [7,8], immunoregulating [9], and antioxidating [10]. In addition, Laminaria japonica polysaccharides have inhibitory effect on a variety of tumor cells, such as liver cancer cells, nasopharyngeal carcinoma cells, cervical cancer cells, and leukemia cells [11][12][13][14], but there are no reports on the effect of Laminaria japonica polysaccharides on human non-small-cell lung cancer A549 cells. In this study, we investigated the effects of Laminaria japonica polysaccharides on the survival of A549 cells in vitro and in vivo and its possible mechanism.…”

Section: Introductionmentioning

confidence: 99%

Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

Yao

Qian

Qin

2019

International Journal of Polymer Science

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Objective. To investigate the effect of Laminaria japonica polysaccharides (LJP) on the survival of non-small-cell lung cancer (NSCLC) A549 cells and its mechanism. Methods. In vitro: the cells were randomly divided into control group, LJP (5 mg/ml) group, LJP (10 mg/ml) group, and LJP (20 mg/ml) group. After corresponding treatment, the survival rate and the expression of proteins related to proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and signaling pathway were detected by CCK8 assay and Western blot, respectively. In vivo: a xenograft model was established to detect the tumor volume and mass and the expression of the above pathway proteins. Results. Compared with the control group, LJP decreased the survival rate of A549 cells (P<0.05), inhibited the protein expression of Ki67 and PCNA (P<0.05), downregulated the expression of Bcl-2 while upregulated the expression of Bax, cl-caspase-3, and cl-caspase-9 (P<0.05), upregulated the expression of E-cadherin, downregulated the expression of vascular endothelial growth factor (VEGF) and N-cadherin (P<0.05), and downregulated β-catenin, transcription factor-4 (TCF4), and c-Myc protein expression levels (P<0.05). In vivo: LJP decreased the volume and mass of the xenograft tumors and downregulated β-catenin, TCF4, and c-Myc protein expression levels compared with the control group (P<0.05). Conclusion. LJP can inhibit the survival of non-small-cell lung cancer A549 cells in vitro, and its mechanism is related to the inhibition of activation of β-catenin/TCF4 pathway activation.

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Laminaria Japonica Polysaccharides effectively inhibited the growth of nasopharyngeal carcinoma cells in vivo and in vitro study

Cited by 19 publications

References 12 publications

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Edible brown seaweeds: a review

Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

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