Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Hsu, Han‐Shui; Hwang, Pai‐An

doi:10.1186/s40169-019-0234-9

Cited by 109 publications

(91 citation statements)

References 97 publications

(151 reference statements)

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“…Several 2019 reviews reveal fucoidans (sulfated polysaccharide mainly derived from brown seaweed) in lung cancer management. Brown algae like Fucus vesiculosus, Turbinaria conoides, Laminaria japonica ( Figure 8) are reported in inhibition of tumor migration and invasion, apoptosis induction and inhibition lung cancer cell progression respectively [159]. Fucus evanescens, Sargassum sp.…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

“…Jazzara et al [170] concluded that λ-carrageenan (sulfated galactans found in certain red seaweeds) could be a promising bioactive polymer, showed a remarkable inhibitory effect on MDA-MB-231(triple negative breast cancer cell line) cell migration [171]. Several studies support polyphenols [172][173][174][175][176], flavonoids [177][178][179][180][181][182][183][184][185][186], fucoidan [159,160,166,[187][188][189][190][191][192][193][194][195], lutein/zeaxanthin [196][197][198][199][200], other seaweed alkaloids, peptides, tannins and polysaccharides [132,164,[201][202][203][204][205][206][207][208][209][210] in breast cancer management. The number of deaths from colorectal cancer in Japan continues to increase [211], it is the third most common diagnosis and second deadliest malignancy for both sexes combined…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

“…High intake of red and processed meat and alcohol increase the risk of colorectal cancer [214]. U. pinnatifida [159,188,[215][216][217][218][219][220][221]…”

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

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Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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The global economic impact of the five leading chronic diseases-cancer, diabetes, mental illness, CVD, and respiratory disease-could reach $47 trillion over the next 20 years, according to a study by the World Economic Forum (WEF). According to the WHO, 80% of the world's population primarily those of developing countries rely on plant-derived medicines for the healthcare. The purported efficacies of seaweed derived phytochemicals showing great potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and some cancers. Therefore, WHO, UN-FAO, UNICEF and governments have shown a growing interest in this unconventional food with health-promoting effects. Edible marine macro-algae (seaweed) are of interest because of their value in nutrition and medicine. Seaweeds contain several bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have beneficial health properties. People consume seaweed as food in various forms: raw as salad and vegetable, pickle with sauce or with vinegar, relish or sweetened jellies and also cooked for vegetable soup. By cultivating seaweed, coastal people are getting an alternative livelihood as well as advancing their lives. In 2005, world seaweed production was totaled 14.7 million tons which more than double (30.4 million tons) in 2015. The present market value is nearly $6.5 billion and projected to reach some $9 billion seaweed global market by 2024. Aquaculture is recognized as the most sustainable means of seaweed production and accounts for approximately 27.3 million tons (more than 90%) of global seaweed production per annum. Asian countries produced 80% for world markets where China alone produces half of the total demand. The top six seaweed producing countries are China,

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Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

Section: Cancer Prevention and Tumor Controlmentioning

confidence: 99%

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Seaweeds: An Extensive Review of Medicinal Values

Mohiuddin¹

2019

APCT

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“…Основным полисахаридом в составе бурых водорослей является фукоидан [42]. В исследованиях in vitro и in vivo на мышах обнаружены иммуномодулирующие, антибактериальные, противовирусные, противовоспалительные и противоопухолевые свойства фукоидана [42][43][44]. В исследованиях на мышах показано, что фукоидан способствует созреванию дендритных клеток [45].…”

Section: обзор литературыunclassified

New methods of prevention and treatment of acute respiratory viral infections in children. Local protection factors of the respiratory mucosa

Геппе

Ozerskaia

Колосова

2019

Ross. vestn. perinatol. pediatr.

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Acute respiratory viral infections (ARVI) are the most common diseases among children. The typical and most disturbing symptoms of ARVI are nasal discharge, nasal congestion and difficulty in nasal breathing. Local protective factors of the respiratory mucosa (epithelial barrier, mucociliary clearance, antimicrobial peptides, immunoglobulin A, microbiota) prevent the penetration of respiratory infections. To prevent ARVI in children it is important to maintain the physiological state of the mucous membrane. ARVI treatment in children is based on care and supportive activities. By irrigating nasal cavity with saline one removes mucus, mechanical impurities, stimulates mucociliary clearance, reduces swelling of the mucous membrane and need for decongestants. The new nasal spray Aqualor Protect contains 45% of sea water with a slightly hypertonic concentration of salts (1.5%) and Ascophillum nodosum brown algae extract. The main polysaccharides of brown algae - fucoidan and ascofillan - have a wide range of biological actions, including anti-inflammatory and antiviral properties. The extract of brown algae added to saline helps to increase the effectiveness of irrigation therapy in the treatment and prevention of acute respiratory viral infections in children.

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“…In the last few years, macroalgae attracted increasing attention from many industries of diverse branches such as fuel, plastics, cosmetics, pharmaceuticals, and food [1,2]. In fact, the chemical diversity within red (Rhodophyta), green (Chlorophyta), and brown (Phaeophyta) macroalgae offers the possibility of finding a wide variety of primary and secondary metabolites, with interesting properties and applications [1,[3][4][5][6][7]. Primary metabolites are directly involved in physiological functions, under normal growth conditions, such as reproduction, while secondary metabolites are mainly excretory products produced under different stress conditions, such as exposure to ultraviolet (UV) radiation, changes in temperature and salinity, or environmental pollutants.…”

Section: Introductionmentioning

confidence: 99%

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

et al. 2019

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Macroalgae are increasingly viewed as a source of secondary metabolites with great potential for the development of new drugs. In this development, in vitro studies are only the first step in a long process, while in vivo studies and clinical trials are the most revealing stages of the true potential and limitations that a given metabolite may have as a new drug. This literature review aims to give a critical overview of the secondary metabolites that reveal the most interesting results in these two steps. Phlorotannins show great pharmaceutical potential in in vivo models and, among the several examples, the anti-dyslipidemia activity of dieckol must be highlighted because it was more effective than lovastatin in an in vivo model. The IRLIIVLMPILMA tridecapeptide that exhibits an in vivo level of activity similar to the hypotensive clinical drug captopril should still be stressed, as well as griffithsin which showed such stunning results over a variety of animal models and which will probably move onto clinical trials soon. Regarding clinical trials, studies with pure algal metabolites are scarce, limited to those carried out with kahalalide F and fucoxanthin. The majority of clinical trials currently aim to ascertain the effect of algae consumption, as extracts or fractions, on obesity and diabetes.Studies focusing on the preparation of macroalgae extracts and their chemical characterization revealed a large range of seaweed compounds with very interesting biological activities including antitumor, anti-inflammatory, antimicrobial, antidiabetic, antivirus, antihypertensive, fat-lowering, and neuroprotective activities [12][13][14][15].The large volume of studies proving the seaweed compound activities in in vitro systems [16][17][18][19] hints the need for further advancements in the knowledge about macroalgae compound efficiency in living systems (in vivo) and their use in the development of pharmaceuticals. In vitro studies are very relevant and yield very important information, but they only represent the first step of a long process, and the results obtained rarely reveal anything about the effects of a compound in vivo, because the responses observed in vitro can be magnified, diminished, or totally different in a more complex and integrated system. In fact, in vivo studies and clinical trials are those which contribute most to truly understanding the real potential of compounds as future pharmaceuticals.In this regard, the present work intends to present insight into the results obtained in the last few years regarding secondary metabolites, such as phlorotannins, halogenated compounds, fucoxanthin, and fucosterol isolated from macroalgae, involved in in vivo studies and clinical trials, identifying the research opportunities and knowledge gaps, to valorize these compounds and their natural resources. The intention is not to present an exhaustive survey of all published works, but rather a selection of authors based on the following criteria: in-depth studies involving pure compounds most characteristic f...

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Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy

Cited by 109 publications

References 97 publications

Seaweeds: An Extensive Review of Medicinal Values

Seaweeds: An Extensive Review of Medicinal Values

New methods of prevention and treatment of acute respiratory viral infections in children. Local protection factors of the respiratory mucosa

Seaweed Secondary Metabolites with Beneficial Health Effects: An Overview of Successes in In Vivo Studies and Clinical Trials

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