Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

Yao, Mengxing; Qian, Xiaojun; Qin, Hou-Ying

doi:10.1155/2019/7929535

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…(dashima) has been proven to exert cytotoxic activity against various cancer types including breast, colon, hepatocellular, lung, and prostate cancer cells, by inhibiting proliferation and inducing apoptosis via both mitochondrialdependent and death receptor rough extrinsic-related pathways [25][26][27][28][29][30]. In addition, similar anticancer effects have been reported for bioactive compounds extracted from Laminaria japonica, such as glycoproteins, polysaccharides, laminarin, fucoxanthin, and phlorotannin [31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 76%

Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer

Hoang

Lee

et al. 2022

Endocrinol Metab

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Background: This study aims to elucidate the associations among dietary seaweed (gim and miyeok/dashima) and iodine intakes, the rs77277498 polymorphism of the SLC5A5 gene codifying the sodium/iodine symporter, and thyroid cancer risk in a Korean population.Methods: We conducted a case-control study of 117 thyroid cancer cases and 173 controls who participated in the Cancer Screenee Cohort between 2002 and 2014 at the National Cancer Center, Korea. The amount of seaweed and iodine consumption (g/day) was estimated using the residual energy adjustment method. We calculated odds ratios (ORs) and their 95% confidence intervals (CIs) using a multivariable logistic regression model for the separate and combined effect of dietary iodine-based intake and SLC5A5 polymorphism (rs77277498, C>G) on thyroid cancer.Results: Dietary gim and iodine intakes were inversely associated with thyroid cancer, with ORs of 0.50 (95% CI, 0.30 to 0.83) and 0.57 (95% CI, 0.35 to 0.95), respectively, whereas the associations for dietary miyeok/dashima and total seaweed intakes were not significant. However, compared with individuals carrying the C/C genotype of the rs77277498 polymorphism with a low intake of all dietary factors, those carrying the G allele with a high intake had a lower risk of thyroid cancer, with ORs of 0.25 (95% CI, 0.10 to 0.56), 0.31 (95% CI, 0.12 to 0.77), 0.26 (95% CI, 0.10 to 0.62), and 0.30 (95% CI, 0.12 to 0.73) for the consumption of gim, miyeok/dashima, total seaweed, and iodine, respectively.Conclusion: In summary, our results supported the evidence of the protective effects of dietary gim and iodine intake against thyroid cancer risk, and this association can be strengthened by SLC5A5 rs77277498 genotypes.

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Section: Discussionmentioning

confidence: 76%

Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer

Hoang

Lee

et al. 2022

Endocrinol Metab

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Biochemical characterization and anti-cancer activity of tangential flow filtration system assisted purification of fucoglucan from Laminaria japonica

Lin

Qiu

et al. 2023

International Journal of Biological Macromolecules

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MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

Chan,

Zhang,

et al. 2024

Aging and disease

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Various diseases, including cancers, age-associated disorders, and acute liver failure, have been linked to the oncogene, MYC . Animal testing and clinical trials have shown that sustained tumor volume reduction can be achieved when MYC is inactivated, and different combinations of therapeutic agents including MYC inhibitors are currently being developed. In this review, we first provide a summary of the multiple biological functions of the MYC oncoprotein in cancer treatment, highlighting that the equilibrium points of the MYC/MAX, MIZ1/MYC/MAX, and MAD (MNT)/MAX complexes have further potential in cancer treatment that could be used to restrain MYC oncogene expression and its functions in tumorigenesis. We also discuss the multifunctional capacity of MYC in various cellular cancer processes, including its influences on immune response, metabolism, cell cycle, apoptosis, autophagy, pyroptosis, metastasis, angiogenesis, multidrug resistance, and intestinal flora. Moreover, we summarize the MYC therapy patent landscape and emphasize the potential of MYC as a druggable target, using herbal medicine modulators. Finally, we describe pending challenges and future perspectives in biomedical research, involving the development of therapeutic approaches to modulate MYC or its targeted genes. Patients with cancers driven by MYC signaling may benefit from therapies targeting these pathways, which could delay cancerous growth and recover antitumor immune responses.

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Effects of Laminaria Japonica Polysaccharides on the Survival of Non-Small-Cell Lung Cancer A549 Cells

Cited by 3 publications

References 28 publications

Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer

Seaweed and Iodine Intakes and SLC5A5 rs77277498 in Relation to Thyroid Cancer

Biochemical characterization and anti-cancer activity of tangential flow filtration system assisted purification of fucoglucan from Laminaria japonica

MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products

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