Laetispicine, an amide alkaloid from Piper laetispicum, presents antidepressant and antinociceptive effects in mice

Chen, Yao; Wang, J.; Dong, Di; Qian, Fu-Gang; Xie, J.; Pan, Shengli

doi:10.1016/j.phymed.2009.02.008

Cited by 41 publications

(25 citation statements)

References 31 publications

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“…As mentioned earlier, the plants of the genus Piper have a great diversity of secondary metabolites and are known for their immunomodulatory, anti-inflammatory, antinociceptive, antipyretic, anti-platelet, antifungic, cytotoxic, antitumor, gastroprotective, anxiolytic and antidepressive properties (Majdalawieh and Carr, 2010;Sunila and Kuttan, 2004;Ganguly et al, 2007;Chiou et al, 2003;Rodrigues Silva et al, 2008;Xie et al, 2011;Yao et al, 2009;Rodrigues et al, 2009;Sireeratawong et al, 2010;Koroishi et al, 2008;Marques et al, 2007;Quílez et al, 2010;Morikawa et al, 2004;Zakaria et al, 2010;Cícero et al, 2007;Navickiene et al, 2000;Bezerra et al, 2006; for review see Sarris et al, 2011). In addition, the literature suggests that the essential oil obtained from some species of Piper also have various biological activities, such as anti-parasitic, insecticidal, larvicidal, antimicrobial, antifungal and antioxidant properties Misni et al, 2011;Salleh et al, 2011;da Silva et al, 2010da Silva et al, , 2011Monzote et al, 2010;Magalhães et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Some species of Piper have been shown to possess several biological actions, such as immunomodulatory, anti-inflammatory, antinociceptive, antipyretic, anti-platelet, antifungic, cytotoxic, antitumor, gastroprotective, anxiolytic and antidepressive properties (Majdalawieh and Carr, 2010;Sunila and Kuttan, 2004;Rodrigues Silva et al, 2008;Xie et al, 2011;Yao et al, 2009;Rodrigues et al, 2009;Sireeratawong et al, 2010;Koroishi et al, 2008;Quílez et al, 2010;Morikawa et al, 2004;Zakaria et al, 2010;Cícero et al, 2007;Bezerra et al, 2006; for review see Sarris et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Lima

Ballico

Lapa

et al. 2012

Journal of Ethnopharmacology

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These data show for the first time that EOPa has significant antinociceptive and anti-inflammatory actions, which do not appear to be related to the opioid system. EOPa also has interesting gastroprotective effects related to the maintenance of protective factors, such as mucus production and GSH. These results support the widespread use of Piper aleyreanum in popular medicine and demonstrate that this plant has therapeutic potential for the development of phytomedicines with antinociceptive, anti-inflammatory and gastroprotective properties.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Lima

Ballico

Lapa

et al. 2012

Journal of Ethnopharmacology

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“…with naloxone (2 mg/kg). In conclusion, we showed that laetispicine possessed significant antidepressant and antinociceptive properties, making this drug potentially useful in depression and pain 13 .…”

Section: Piper Tuberculatummentioning

confidence: 78%

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2011

IJPSR

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Depression is a heterogenous mood disorder that has been classified and treated in variety of ways. Although a number of synthetic drugs are being used as standard treatment for clinically depressed patient, they have adverse effects that can compromise the therapeutic treatment .Thus, it is worthwhile to look for antidepressant from plants with proven advantage and favorable benefit to risk ratio. A number of medicinal plants and medicine derived from these plants have shown antidepressant properties by virtue of combined effect of their medicinal constituents. The causes of depression are decreased brain levels of monoamines like noradrenaline, dopamine and serotonin. Therefore, drugs restoring the reduced levels of these monoamines in the brain either by inhibiting monoamine oxidase or by inhibiting reuptake of these neurotransmitters might be fruitful in the treatment of depression. The present review is focused on the medicinal plants and plants based formulations having antidepressant activity in animal studies and in humans.

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“…Decades of investigations in the natural products chemistry of the Piper genus yielded an important amount of monomeric and dimeric alkamides of diverse molecular architectures contributing to their biological activities [20][21][22][23]203,[208][209][210][211][212][213][214][215][216][217][218][219]. Specifically, [4 + 2] dimers were isolated in P. chaba while [2 + 2] dimers were isolated in P. nigrum and P. longum, in both cases together with monomeric amides.…”

Section: Piperine and Piperovatinmentioning

confidence: 99%