Natural and Synthetic Alkamides

Rios, Marı́a Yolanda; Olivo, Horacio F.

doi:10.1016/b978-0-444-63430-6.00003-5

Cited by 35 publications

(10 citation statements)

References 228 publications

(220 reference statements)

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“…It has been shown in vitro and in animal studies that alkamides like spilanthol, the main bioactive component of acmella, exert a spectrum of different biological activities. With regards to pain and chronic joint inflammatory disorders, the most promising one is the penetration enhancing effect on model drugs, 29 strong local anesthetic, 11 analgesic, 6,12,[30][31][32][33][34][35][36][37][38][39] antinociceptive, 40,41 antioxidant, 36 and antinflammatory 12 without causing adverse effects. 42 Ginger may have anti-inflammatory effects by inhibiting COX and lipoxygenase.…”

Section: Discussionmentioning

confidence: 99%

The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis

Rondanelli

Riva

Allegrini

et al. 2020

JPR

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Purpose: To evaluate the efficacy of a new food-grade lecithin formulation of standardized extracts of Zingiber officinale and Acmella oleracea on pain and inflammation. Patients and Methods: Pilot study with one-group pretest-posttest quasi-experimental design in which 50 subjects with moderate knee osteoarthritis (OA) (mean age: 62.46±8.45) were supplied for four weeks with two tablets/day. Results: Primary outcomes were 1) the evaluation of pain intensity, by a 30-day visual analogue scale (VAS) and 2) the assessment of knee function by WOMAC (Western Ontario and McMaster Universities Arthritis) Index and by Tegner Lysholm Knee Scoring collected at baseline, at 15 and 30 days after treatment. Secondary outcomes were 3) health-related quality of life, by the ShortForm36 (SF-36); 4) inflammation grade by C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR); and 5) body composition by dual-energy X-ray absorptiometry (DXA) measured at baseline and 30 days after treatment. Data showed significant effects of supplement intake for WOMAC (β=−3.27, p<0.0001), Lysholm (β=1.06, p=0.0003), CRP (β=−0.13, p=0.006), ESR (β=−3.09, p=0.004), physical activity (β=4.3, p=0.009) and fat-free mass (β=376.7, p=0.046). A significant VAS's decrease over time was observed in both knees (left: β=−0.08, p<0.0001; right: β=−0.07, p<0.0001). Conclusion: The tested formulation seems to be effective and also free of side effects.

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Section: Discussionmentioning

confidence: 99%

The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (Zingiber officinale) and Acmella oleracea Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis

Rondanelli

Riva

Allegrini

et al. 2020

JPR

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“…When the leaves and flowers are chewed, they cause a tingling sensation to tongue and lips due to the presence of alkylamides, the most abundant in A. oleracea being spilanthol. This isobutylamide derivative presents local anesthetic action and this effect justifies the traditional use for treating toothache [ 1 , 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Sut

Ferrarese

Shrestha

et al. 2020

Plants

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Acmella oleracea is a promising cosmetic, nutraceutical, and pharmaceutical ingredient, and plants with high levels of active compounds are needed in the market. Cultivation can be valuable if sufficient levels of alkylamides are present in plant material. In this regard the application of biostimulants can be an innovative approach to increase yield of cultivation or bioactive compound levels. A. oleracea plants were cultivated in Northern Italy in an experimental site using three different types of biostimulants, triacontanol-based mixture (Tria), an extract from plant tissues (LL017), and seaweed extract (Swe). Plants were grown in the field in two different growing seasons (2018 and 2019). After treatments inflorescences were harvested and the quali-quantitative analysis of alkylamides and polyphenols was performed. Treated and control plants were compared for yields, morphometric measurements, quali-quantitative composition in secondary metabolites. Overall results show that both triacontanol-based mixture and the LL017 positively influenced plant growth (Tria >+ 22%; LL017 >+ 25%) and flower production (Tria >+ 34%; LL017 >+ 56%). The amount of alkylamides and polyphenols in flowers were between 2.0–5.2% and 0.03–0.50%, respectively. Biostimulant treatments ensure higher cultivation yields and allow maintenance of the alkylamide and polyphenol levels based on % (w/w), thus offering an advantage in the final quantity of extractable chemicals. Furthermore, data revealed that samples harvested in late season show a decrease of polyphenols.

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“…Capsaicin is responsible for the distinctive pungent taste of chili; it is a naturally occurring vanilloid alkaloid found in adequate amounts in the placental tissue and, to a lesser extent, in the seeds and fruit pericarp of chilies [26]. Capsaicin's spicy nature is due to its vanillyl moiety, which is also responsible for its detrimental consequences when used therapeutically [27]. Capsaicin is a highly volatile, hydrophobic, odorless, and colorless alkaloid with a molecular weight of 305.4 kDa and a melting point of 62-65°C.…”

Section: Capsaicinmentioning

confidence: 99%

“…Coughing, dry mouth, bronchitis, gastric ulcers, backaches, cholera, gout, hydration, rheumatism, cramping, dysentery, dyspepsia, and dentistry are all folk medical uses for capsicum [43,44]. Despite its widespread use, little was known about the biological action of capsaicin until recently, when its unique actions on sensory neurons were discovered [27].…”

Section: Capsaicinmentioning

confidence: 99%

Therapeutic Properties of Capsaicin: A Medicinally Important Bio-Active Constituent of Chilli Pepper

Singh

UDDIN

Khan

et al. 2022

Asian J Pharm Clin Res

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Plants are the source of numerous pharmaceutically important compounds that have been employed to cure various human ailments since ancient times. With the assistance of modern chemistry and materials science, such pharmaceutically important compounds have been identified and isolated to produce new drugs. Alkaloids are one of the most significant classes of naturally occurring secondary-metabolites, which are synthesized and widely distributed in various parts of plants. They regulate various metabolic activities and induce physiological responses in the human body. Capsaicin is a naturally occurring alkaloid found in many species of peppers and is attributed to their spicy nature and pungent flavor. This alkaloid is a member of the Capsaicinoids group, which includes capsaicin, homocapsaicin, homodihydrocapsaicin, dihydrocapsaicin, and nordihydrocapsaicin. Capsaicin has a wide range of therapeutic potential against various human ailments. In this article, we provide a comprehensive overview of the capsaicin molecule as well as an examination of its medicinal properties in a variety of human disorders, including pain, various types of cancer, ulcers, diabetes, obesity, inflammation, cardiovascular diseases, and neurodegenerative diseases.

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Natural and Synthetic Alkamides

Cited by 35 publications

References 228 publications

<p>The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (<em>Zingiber officinale</em>) and <em>Acmella oleracea</em> Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis</p>

<p>The Use of a New Food-Grade Lecithin Formulation of Highly Standardized Ginger (<em>Zingiber officinale</em>) and <em>Acmella oleracea</em> Extracts for the Treatment of Pain and Inflammation in a Group of Subjects with Moderate Knee Osteoarthritis</p>

Comparison of Biostimulant Treatments in Acmella oleracea Cultivation for Alkylamides Production

Therapeutic Properties of Capsaicin: A Medicinally Important Bio-Active Constituent of Chilli Pepper

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