Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Lima, Daniella Karine Souza; Ballico, Laudir J.; Lapa, Fernanda R.; Gonçalves, Hilda P.; Souza, Lauro Mera de; Iacomini, Marcello; Werner, Maria Fernanda de Paula; Baggio, Cristiane Hatsuko; Pereira, Isabela Tiemy; Silva, Luísa Mota da; Facundo, Valdir Alves; Santos, Adair R.S.

doi:10.1016/j.jep.2012.05.016

Cited by 56 publications

(38 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, their bioactivity as antibacterial, antiviral, antioxidant and antidiabetic agents has previously been reported (18). Recent studies have demonstrated the anti-inflammatory properties of essential oils from several plants (19)(20)(21). In the present study, we demonstrated that the essential oil from C. obtusa has an anti-inflammatory effect on LPS-induced inflammation in rats.…”

Section: Discussionsupporting

confidence: 62%

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

View full text Add to dashboard Cite

Abstract. Essential oils are concentrated hydrophobic liquids containing volatile aromatic compounds from plants. In the present study, the essential oil of Chamaecyparis obtusa (C. obtusa), which is commercially used in soap, toothpaste and cosmetics, was extracted. Essential oil extracted from C. obtusa contains several types of terpenes, which have been shown to have anti-oxidative and anti-inflammatory effects. In the present study, we examined the anti-inflammatory effects of C. obtusa essential oil in vivo and in vitro following the induction of inflammation by lipopolysaccharides (LPS) in rats. While LPS induced an inflammatory response through the production of prostaglandin E 2 (PGE 2 ) in the blood and peripheral blood mononuclear cells (PMNCs), these levels were reduced when essential oil was pre-administered. Additionally, the mechanism of action underlying the anti-inflammatory effects of C. obtusa essential oil was investigated by measuring the mRNA expression of inflammation-associated genes. LPS treatment significantly induced the expression of transforming growth factor α (TNFα) and cyclooxygenase-2 (COX-2) in rats, while C. obtusa essential oil inhibited this effect. Taken together, our results demonstrate that C. obtusa essential oil exerts anti-inflammatory effects by regulating the production of PGE 2 and TNFα gene expression through the COX-2 pathway. These findings suggest that C. obtusa essential oil may constitute a novel source of anti-inflammatory drugs.

show abstract

Section: Discussionsupporting

confidence: 62%

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Kang

Yang

et al. 2013

Molecular Medicine Reports

View full text Add to dashboard Cite

show abstract

“…The gastroprotective activity of ␤-caryophyllene (2) has been previously reported (Tambe et al, 1996). Literature data show that the compounds quercetin, caryophyllene oxide and ␣-humulene are present in the chemical composition of extracts and essential oils with gastroprotective activity (Esteves et al, 2005;Lima et al, 2012;Zakaria et al, 2014). It is important to emphasize that is the first time that the gastroprotective activity of (1), caryophyllene oxide (3), kaurenoic acid (4), quercitrin (5) and afzelin (6) as pure compounds is showed.…”

Section: Resultsmentioning

confidence: 96%

Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

Lemos

Santin

Mizuno

et al. 2015

Revista Brasileira de Farmacognosia

View full text Add to dashboard Cite

Revista Brasileira de Farmacognosia 25 (2015) 238-245 w w w . s b f g n o s i a . o r g . b r / r e v i s t a a b s t r a c tGastric ulcer is a prevalent gastrointestinal disease, and the drugs currently used in the treatment produce several adverse effects. In this context, the search for new therapeutic antiulcer agents is essential, and medicinal plants have great potential. Here, we investigated the gastroprotective properties of Copaifera langsdorffii Desf., Fabaceae, hydroalcoholic extract obtained from leaves and its isolated compounds. The phytochemistry studies and the compounds isolations were performed using chromatographic and spectroscopic methodologies. The hydroalcoholic extract was evaluated using ethanol/HCl, non-steroidal anti-inflammatory drug, stress-induced-ulcer and chronic ulcer-model. The effects on gastric content volume, pH, total acidity and mucus stomach production were evaluated in the pylorus ligated-model. The C. langsdorffii extract obtained from leaves (50, 250 or 500 mg/kg) reduced the injured area compared to control group in all experiments. The extract showed a significant decrease in the total gastric juice acidity and an increase in mucus production (500 mg/kg) when compared to vehicle. Among isolated compounds (30 mg/kg) ␣-humulene, ␤-caryophyllene and caryophyllene oxide showed greater gastroprotective activity in the ethanol/HCl induced ulcer model. The data herein obtained shown that C. langsdorffii leaves extract and isolated compounds from it, presented gastroprotective properties in different animal models of gastric ulcer. These effects may be associated with the ability of the extract to decrease gastric secretion and increase the mucus production.

show abstract

“…The inflammatory response in a carrageenan-induced pleurisy culminates in exudation and leukocyte infiltration, which release chemical mediators responsible for the cardinal signals of inflammation, namely, edema, pain, heat, redness, and loss of function [32]. It is clear that protein exudation is more closely related to edema than to other events [33].…”

Section: Discussionmentioning

confidence: 99%

“…In the first phase of the test, intraplantar injections of formalin produce neurogenic pain, which combines a peripheral input and a spinal cord sensitization [32]. This phase is associated with an acute pain that starts immediately after the injection and involves nociceptors.…”

Section: Discussionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Verdam

Guilhon-Simplicio

Andrade

et al. 2017

The Scientific World Journal

View full text Add to dashboard Cite

Background. Byrsonima is a promising neotropical genus, rich in flavonoids and triterpenes, with several proven pharmacological properties. Nevertheless, Byrsonima duckeana W. R. Anderson is an Amazonian species almost not studied. Objective. To assess the antioxidant, anti-inflammatory, and analgesic activities of Byrsonima duckeana leaves. Materials and Methods. We analyzed an ethanol extract and its fractions for polyphenol content and UHPLC-MS/MS, phosphomolybdenum, DPPH, TBARS antioxidant tests, formalin-induced pain, carrageenan-induced peritonitis, acetic acid-induced abdominal writhings, and hot plate assays. Results. All the samples showed high polyphenol content and antioxidant capacity in the phosphomolybdenum, DPPH, and TBARS tests. We identified ethyl gallate, quinic acid, gallic acid, catechin, epicatechin, quercetrin, and quercetin in the samples. B. duckeana was able to reduce leukocyte migration in the carrageenan-induced peritonitis by 43% and the licking time in the formalin test by 57%. In the acetic acid-induced writhing test, the chloroform (FCL) and ethyl acetate (FEA) fractions were the most active samples. FEA was selected for the hot plate test, where all the dosages tested (5, 50, and 200 mg·kg−1) showed significant analgesic activity. Conclusion. B. duckeana has interesting analgesic and antioxidant activities, due to its high phenolic content, especially phenolic acids.

show abstract

Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents

Cited by 56 publications

References 65 publications

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Anti-inflammatory effects of essential oils from Chamaecyparis obtusa via the cyclooxygenase-2 pathway in rats

Copaifera langsdorffii: evaluation of potential gastroprotective of extract and isolated compounds obtained from leaves

Analgesic, Anti-Inflammatory, and Antioxidant Activities of Byrsonima duckeana W. R. Anderson (Malpighiaceae)

Contact Info

Product

Resources

About