Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin

Kraan, Marieke I.A. van der; Groenink, J.; Nazmi, Kamran; Veerman, E.C.I.; Bolscher, Jan G. M.; Amerongen, A. van Nieuw

doi:10.1016/j.peptides.2003.12.006

Cited by 224 publications

(150 citation statements)

References 39 publications

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“…Following the initial discovery of LFampin 268-284 (produced by solid-phase chemistry), a slightly longer sequence (produced by action of a single endopeptidase on bLf) was published that included an additional N-terminal helix cap region, Asp-Leu-Ile. It was found that the longer peptide LFampin 265-284 had higher activity [123]. For both peptides, the helical conformation was found to be critical for effectiveness against Gram-positive bacteria [124].…”

Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

“…The sequence comparison of Lfampin from six different species shows a uniform preponderance of cationic amino acid residues among hydrophobic residues ( Table 5). As an antimicrobial peptide Lfampin plays a key role in membrane-mediated activities of Lf [123]. Following the initial discovery of LFampin 268-284 (produced by solid-phase chemistry), a slightly longer sequence (produced by action of a single endopeptidase on bLf) was published that included an additional N-terminal helix cap region, Asp-Leu-Ile.…”

Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

“…Lfampin exhibits broad antimicrobial action against several Gram-positive and Gram-negative bacteria, yeast and parasites: data taken from the MilkAMP database are reported in Table 6 [14,123]. Although no advanced preclinical trials or applications have yet been reported, the study by Flores et al shows that the combination of ampicillin with LFcin 17-30 or LFampin 265-284 enhanced the inhibitory effect on growth of S. aureus (99.9%) for both peptides, suggesting that a synergistic effect occurs.…”

Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

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Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Bruni¹,

et al. 2016

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Antimicrobial peptides (AMPs) represent a vast array of molecules produced by virtually all living organisms as natural barriers against infection. Among AMP sources, an interesting class regards the food-derived bioactive agents. The whey protein lactoferrin (Lf) is an iron-binding glycoprotein that plays a significant role in the innate immune system, and is considered as an important host defense molecule. In search for novel antimicrobial agents, Lf offers a new source with potential pharmaceutical applications. The Lf-derived peptides Lf(1-11), lactoferricin (Lfcin) and lactoferrampin exhibit interesting and more potent antimicrobial actions than intact protein.Particularly, Lfcin has demonstrated strong antibacterial, anti-fungal and antiparasitic activity with promising applications both in human and veterinary diseases (from ocular infections to osteo-articular, gastrointestinal and dermatological diseases).

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Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

Section: Lf Derived Peptides: Lactoferrampinmentioning

confidence: 99%

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Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Bruni¹,

et al. 2016

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“…The polar/nonpolar character of lactoferricin makes its structure similar to cationic peptides which exert their antimicrobial activities through membrane disruption [122]. Another bactericidal N-terminal fragment of bovine Lf has recently been described [193]. It can be hypothesized that bioactive fragments of Lf are generated in milk during infection by proteases in milk.…”

Section: Humoral Defensesmentioning

confidence: 99%

Innate immunity of the bovine mammary gland

2006

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-Understanding the immune defenses of the mammary gland is instrumental in devising and developing measures to control mastitis, the major illness of dairy ruminants. Innate immunity is an extremely broad field for investigation, and despite decades of research, our present knowledge of the innate defenses of the udder is incomplete. Yet, information is being gained on the recognition of pathogens by the mammary gland, and on several locally inducible defenses. The contribution of mammary epithelial cells to local defenses and to the mobilization of leucocytes is under growing scrutiny. Interactions of mastitis-causing bacteria such as Escherichia coli or Staphylococcus aureus and the mammary gland represents a suitable model for studies on innate immunity at an epithelium frontier. Powerful new research tools are radically modifying the prospects for the understanding of the interplay between the mammary gland innate defenses and mastitis-causing bacteria: genetic dissection of the immune response, microarray gene technology, transcriptomic methodologies and gene silencing by RNA interference will make possible the discovery of several of the key defense mechanisms which govern the susceptibility/resistance to mastitis at the molecular and genetic levels. It should then be possible to enhance the resistance of dairy ruminants to mastitis through immunomodulation and genetic improvement. mastitis / cattle / innate immunity / inflammation / milk

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“…LPS makes these bacteria susceptible to phagocytosis by cells of immune system. There are various other mechanisms purposed for its action [11][12][13][14][15] (Table 2). …”

Section: Mechanism Of Actionmentioning

confidence: 99%

Lactoferrin and Its Role in Neonatology: A Review Article

Sharma¹

2015

JPNC

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Lactoferrin (LF) is a glycoprotein, which is present in milk of mammals. It has been proven to plays a very important role in innate immune host defences. It is well known that Neonatal sepsis and necrotizing enterocolitis (NEC) are responsible for significant morbidity and mortality in the new-born, especially in VLBW (1500 grams at birth) infants. The ill effects of sepsis and NEC persist in spite of appropriate and effective antibiotic therapy and have been associated with poor long term outcome. In the few recent trials which have been conducted around the globe, in field of neonatology, role of LF in prevention of neonatal sepsis and NEC has been strengthened. Furthermore many trials are underway and only future may provide a definite answer of LF role in sepsis and NEC. This review article has been written to through some light on the recent work that has already been done, to strengthen the role of LF in neonatal sepsis and the work that is still under process.

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Lactoferrampin: a novel antimicrobial peptide in the N1-domain of bovine lactoferrin

Cited by 224 publications

References 39 publications

Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Innate immunity of the bovine mammary gland

Lactoferrin and Its Role in Neonatology: A Review Article

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