Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Bruni, Natascia; Capucchio, Maria Teresa; Biasibetti, Elena; Pessione, Enrica; Cirrincione, Simona; Giraudo, Leonardo; Corona, A.; Dosio, Franco

doi:10.3390/molecules21060752

Cited by 159 publications

(127 citation statements)

References 129 publications

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“…Alignment comparison of human and cow lactoferricin shows that these regions have little homology between the two species (41%) (Fig. 4A), despite shared attributes of amphipathic residues and positive charge (Bruni, Capucchio, Biasibetti, Pessione, Cirrincione, Giraudo, et al, 2016). Still, both human and cow lactoferricin exert antimicrobial activity.…”

Section: Resultsmentioning

confidence: 99%

Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization

et al. 2017

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During processing and digestion, milk proteins are disassembled into peptides with an array of biological functions, including antimicrobial, angiotensin-converting enzyme inhibition, antioxidant, opioid, and immunomodulation. These functions are summarized in numerous reviews, yet information on which peptides have which functions remains scattered across hundreds of research articles. We systematically searched the literature for all instances of bioactive peptides derived from milk proteins from any mammalian source. The data were compiled into a comprehensive database, which can be used to search for specific functions, peptides, or proteins (http://mbpdb.nws.oregonstate.edu). To review this large dataset, the bioactive peptides reported in the literature were visually mapped on the parent protein sequences, providing information on sites with highest abundance of bioactive peptides.

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Section: Resultsmentioning

confidence: 99%

Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization

et al. 2017

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“…Lactoferrin and its related peptides shows the potential for a number of clinical uses, ranging from wound healing and the detection of bacteria to the treatment of microbial infections both alone and in combination with other clinically relevant agents [272]. A full description of these medical uses is beyond the scope of this review but lactoferrin and its derivatives have featured in multiple clinical trials [160,272,273] and have numerous entries in a recently constructed database of bioactive peptides derived from milk proteins [274].…”

Section: Potential Applications Of Ph Dependent Antimicrobial Peptmentioning

confidence: 99%

pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents

et al. 2016

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Antimicrobial peptides (AMPs) are potent antibiotics of the innate immune system that have been extensively investigated as a potential solution to the global problem of infectious diseases caused by pathogenic microbes. A group of AMPs that are increasingly being reported are those that utilise pH dependent antimicrobial mechanisms, and here we review research into this area. This review shows that these antimicrobial molecules are produced by a diverse spectrum of creatures, including vertebrates and invertebrates, and are primarily cationic, although a number of anionic examples are known. Some of these molecules exhibit high pH optima for their antimicrobial activity but in most cases, these AMPs show activity against microbes that present low pH optima, which reflects the acidic pH generally found at their sites of action, particularly the skin. The modes of action used by these molecules are based on a number of major structure/function relationships, which include metal ion binding, changes to net charge and conformational plasticity, and primarily involve the protonation of histidine, aspartic acid and glutamic acid residues at low pH. The pH dependent activity of pore forming antimicrobial proteins involves mechanisms that generally differ fundamentally to those used by pH dependent AMPs, which can be described by the carpet, toroidal pore and barrel-stave pore models of membrane interaction. A number of pH dependent AMPs and antimicrobial proteins have been developed for medical purposes and have successfully completed clinical trials, including kappacins, LL-37, histatins and lactoferrin, along with a number of their derivatives. Major examples of the therapeutic application of these antimicrobial molecules include wound healing as well as the treatment of multiple cancers and infections due to viruses, bacteria and fungi. In general, these applications involve topical administration, such as the use of mouth washes, cream formulations and hydrogel delivery systems. Nonetheless, many pH dependent AMPs and antimicrobial proteins have yet to be fully characterized and these molecules, as a whole, represent an untapped source of novel biologically active agents that could aid fulfillment of the urgent need for alternatives to conventional antibiotics, helping to avert a return to the pre-antibiotic era.

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“…35,36 Köpeklerde ise peynir altı suyu bileşiklerinin bakteriyel otitte, antimikrobiyal ve antifungal olarak ve enteritte küratif olarak etkinliğini ortaya koyan çalışmalar bulunmaktadır. [38][39][40] Ayrıca, peynir altı suyu ticari olarak köpek ve kedilerde yenidoğan ikame preparasyonları ile ek besin maddelerinin muhtevasına eklenmektedir.…”

Section: Veteri̇ner Heki̇mli̇kte Terapöti̇k Kullanim Alanlariunclassified

Whey Protein: A New Supportive and Regenerative Therapy Chance Ignored in Veterinary Medicine: Review

Dalğın¹,

Yücel²

2016

Turkiye Klinikleri J Vet Sci

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Ö ÖZ ZE ET T Peynir altı suyu, daha önceleri, peynir yapımının bir atık ürünü olarak ele alınmakta idi, fakat son yıllarda bileşimi ortaya konularak, içeriği oluşturan aminoasit, immünglobulin, büyüme faktörleri gibi maddelerin antimikrobiyal, antiviral, antifungal, epitelizan, immün stimülan, rejeneratif gibi birçok terapötik etkileri tanımlanmıştır. Beşerî hekimlikte peynir altı suyu immün stimülasyon amacıyla özellikle yaş-lılarda iskemik atakta, "human immunodeficiency virus" (HIV) enfeksiyonunda, pek çok hastalıkta antimikrobiyal amaçlı (Escherichia coli, Salmonella typhimurium, Shigella dysenteriae, Listeria monocytogenes, Bacillus stearothermophilus, Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, Listeria monocytogenes, Candida albicans ve Helicobacter pylori), egzersiz ve sporcularda kas yapımında, gastrointestinal sistem hastalıklarında, kanser hastalarında, osteoporözde, ağız ve diş sağlığında, depresyon, stres ve kozmetik sektörü gibi pek çok alanda kullanılmaktadır. Oysa güncel literatür tarandığında, bu ürünün maalesef veteriner hekimlik alanında çok fazla araştırılmamış, özellikle de rutin kullanıma girmekten çok uzak olduğu görülmektedir. Doğal ve maliyeti düşük olan peynir altı suyunun, ister toz hâ-linde, ister taze sıvı hâlde; barsak hastalıkları, köpeklerin parvoviral enteritisi, yangısal barsak hastalığı, yenidoğan ve gelişme geriliği gösteren yavrular, viral, bakteriyel, paraziter hastalıklar, geriatri, kanser hastalığı gibi durumlarda destek ve rejeneratif tedavi yönünden değerlendirilmesi ile terapi başarısına önemli ölçüde katkı sağlayacağı kanaatindeyiz. Bu çalışmada, peynir altı suyunun içeriği, beşerî ve veteriner hekimlik sahasında kullanım alanları özetlenmiştir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Vey protein; veterinerlik bilimi; tedavi A AB BS S T TR RA AC CT T Whey was a waste product of cheese manufacturing previously, but in the last decades with the identification of its content, it is used in many areas of human medicine as a supportive element because of the antimicrobial, antiviral, antifungal, epithelialing, immune stimulant, regeneratif effects due to its amino acid, immune globuline, growth factors etc. components. Major areas whey proteins are used in human medicine are immune stimulation, ischemic attack especially in elderly, , human immunodeficiency virus (HIV) infection, in many disorders as antimicrobials (Escherichia coli, Salmonella typhimurium, Shigella dysenteriae, Listeria monocytogenes, Bacillus stearothermophilus, Bacillus subtilis, Micrococcus luteus, Pseudomonas aeruginosa, Listeria monocytogenes, Candida albicans and Helicobacter pylori), exercise and by sportsmen for muscle protein synthesis, gastrointestinal system disorders, neoplastic disorders, osteoporesis, oral and dental health, depression and stress and cozmetic areas. Unfortunately, current literature shows that this product has not been invesitigated and very far from clinical application in veterinary medicine. The authors opinion is that, this economically ...

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Antimicrobial Activity of Lactoferrin-Related Peptides and Applications in Human and Veterinary Medicine

Cited by 159 publications

References 129 publications

Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization

Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization

pH Dependent Antimicrobial Peptides and Proteins, Their Mechanisms of Action and Potential as Therapeutic Agents

Whey Protein: A New Supportive and Regenerative Therapy Chance Ignored in Veterinary Medicine: Review

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