Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside‐based topical emulsions: the colloidal structure, stability and efficacy evaluation

Abstract

Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The α-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for α-tocopherol in the same vehicle.

Comparison of the Skin Lipid Layer in Acne Vulgaris Patients after Treatment with 50% Lactobionic Acid, Corundum Microdermabrasion and a Combination of Both Means

“…This is because of the polyhydroxyl structural motif, resembling to a certain extent glycosaminoglycans. Taking into account that the physicochemical parameters of LA (molecular mass 358 g/mol and pKa = 3.8) and its structure are similar to those for glycolic acid [11]- [15], one may expect for LA some exfoliating properties.…”

An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances

“…Their findings have shown that lactobionic acid, as a highly hygroscopic substance, strongly influenced the colloidal structure of the emulsion based on APGs and even promoted the formation of lamellar structures thus influencing the mode of water distribution within the cream [154]. The investigation of glycolic acid efficacy confirmed that, when incorporated in an APG-based emulsion, this active shows less irritation [156]. Also, significantly improved skin moisturization and lack of skin irritation and damage, which are demonstrated in this study,a re explained with the effect of APG-based vehicle itself.…”

Effects of freezing and the cryoprotectant lactobionic acid in the structure of GlnK protein evaluated by circular dichroism (CD) and isothermal titration calorimetry (ITC)

“…It has created great interest among the food, pharmaceutical, chemical and cosmetics industries due to its functional properties (Gutiérrez et al 2012). The additive is approved by the US FDA (Food and Drug Administration) (FDA 2014) and has chelating, moisturizing and antioxidant properties (Isaacson et al 1989;Green et al 2009;Tasic-Kostov et al 2012).…”