Lactobacillus probiotics for treating functional dyspepsia in children

Abstract

Background Functional dyspepsia is a common gastrointestinal

Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies

“…2 The prevalence of FD, calculated using large population-based studies in adults, ranges from 10% to 30% worldwide, 4 while in children, prevalence varies between 3.5% and 27%. 5 In the USA alone, social and economic costs are estimated to be approximately $18.4 billion/year for adults and $5.79 billion/year for children. 4,6 Functional dyspepsia is a chronic GI disorder defined by upper abdominal symptoms originating from the gastroduodenal region and characterized by the absence of morphological disease on routine investigations, including upper GI endoscopy.…”

“…20 Treatment with Lacticaseibacillus rhamnosus (formerly Lactobacillus rhamnosus) and Lactobacillus acidophilus has been shown to alleviate FD symptoms in children. 5 In adults, the administration of probiotic yogurt containing Lactobacillus gasseri OLL2716 (LG21 yogurt) improved the symptoms of postprandial distress. 21 One advantage exerted by the administration of probiotics as a treatment to control FD is the lack of adverse events reported in the available literature.…”

Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome–Gut–Brain Axis in the Pathophysiology and Case Management

“…Studies show that not only antibiotic therapies during the postnatal period and in early life can promote future FGID in later childhood and adulthood, but also neurodevelopmental disorders, behavioral and mood disruptions are more susceptible to appear later in life. Even more so, Alzheimer's Disease is also supposed to have connections to antibiotic-altered microbiome in childhood, resulting in high amyloid plaque depositing [74] There are several studies that target modulation of microbiome-gut-brain axis in children through antibiotics by analyzing cocktail administrations of broad-spectrum antibiotics and specific antibiotics in different age groups and highlighting the blood-brain penetration capacity of those antibiotics as a direct or indirect influencing factor on the gut health and mental health [75,76]. In the majority of the cases, antibiotics produced important dysbiosis, altered metabolic pathways, promoted gut inflammation, decreased the microglial developmental rate and levels of brain-derived neurotrophic factor and induced cognitive, behavioral and mood impairments, resulting in a double susceptibility to neuropsychiatric disorders and FGID, in later childhood and adulthood [77,78].…”

Корекція Кишкової Мікробіоти В Лікуванні Синдрому Подразненого Кишечника В Дітей

“…Очень похожие результаты получили коллеги из педиатри-ческой клиники университета Северной Суматры в городе Медан (Индонезия) в РКИ с участием 116 де-тей, страдающих СРК. Курсовой прием Lactobacillus reuteri DSM 17938 сопровождался снижением интен-сивности и частоты эпизодов боли по сравнению с контрольной группой, но не влиял на диспептиче-ские проявления заболевания [24]. Хорватские га-строэнтерологи изучали влияние 8-месячного кур-са Lactobacillus reuteri DSM 17938 на клиническое течение СРК у 55 детей в РКИ.…”