Magnesium orotate has been cited in the medical literature for the past three years as a possible adjuvant in some pediatric and adult gastroenterological disorders associated with dysbiosis. Studies also focus on the possibility of adding magnesium orotate in psychiatric disorders’ treatment, such as major depression and anxiety. The most relevant element in these studies is the efficiency of magnesium orotate therapy in cases with both gastroenterological and psychiatric symptoms. This article proposes a literature review, focused on the studies published in the last three years, targeting magnesium orotate treatment and probiotic supplementation in patients with both digestive and psychiatric symptoms. Moreover, this review will compare the efficiency of magnesium orotate and probiotics within both the pediatric and adult communities, focusing on the possibility of gut–brain axis modulation and its involvement in the clinical evolution of these patients.
Ricin, a toxic glycoprotein found in the seeds of castor oil plant, is capable of irreversible cellular adhesion and inhibition of protein synthesis. The authors performed an up to date review concerning the chemical structure, mechanism of action, poisoning symptoms and treatment, and potential uses of ricin as a biochemical weapon. Castor oil plant is easy to cultivate and harvest worldwide and, except the United States of America, cultures and processing plants are not supervised. Ricin extraction does not require laborious and costly technique and it is undetectable once in the body (except for urine in case of ricin ingestion). Poisoning generates nonspecific symptoms and is potentially fatal with no antidote or specific treatment available. Forensic specialists must be aware of symptoms and post-mortem findings in order to make a correct diagnosis of ricin poisoning.
Functional Gastrointestinal Disorders have been an important cause of poor life quality in affected populations. The unclear etiology and pathophysiological mechanism alter the clinical evolution of the patient. Although a strong connection with psychological stress has been observed, it was not until recently that the gut–brain axis involvement has been revealed. Furthermore, the current literature not only promotes the gut–brain axis modulation as a therapeutical target for functional digestive disorders but also states that the gut microbiome has a main role in this bi-directional mechanism. Psychiatric symptoms are currently recognized as an equally important aspect of the clinical manifestation and modulation of both the digestive and central nervous systems and could be the best approach in restoring the balance. As such, this article proposes a detailed description of the physiology of the microbiome–gut–brain axis, the pathophysiology of the functional gastrointestinal disorders with psychiatric symptoms and current perspectives for therapeutical management, as revealed by the latest studies in the scientific literature.
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