Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders

Șchiopu, Cristina Gabriela; Ştefănescu, Gabriela; Diaconescu, Smaranda; Bălan, Gheoghe G.; Gimiga, Nicoleta; Rusu, Elena; Moldovan, Cosmin; Popa, Bogdan; Tataranu, Elena; Olteanu, Andrei Vasile; Boloș, Alexandra; Ștefănescu, Cristinel

doi:10.3390/nu14081567

Cited by 17 publications

(12 citation statements)

References 83 publications

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“…47 It has been reported that the oral adjuvants of their metal compounds were effective in gut–brain axis modulation to ameliorate neurological disorders. 48–50 Besides, Il-15rα mutant mice showed the upregulation of glyoxylate and dicarboxylate metabolism, in which d -glyceric acid, glycolic acid and phosphoglycolic acid were involved. Changes in the glyoxylate and dicarboxylate metabolism were also observed in an integrated analysis of the gut microbiome and host metabolism in humans with metabolic diseases (obesity, type 2 diabetes and atherosclerotic cardiovascular disease).…”

Section: Discussionmentioning

confidence: 99%

Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation

Tong

et al. 2022

Mol. Omics

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Section: Discussionmentioning

confidence: 99%

Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation

Tong

et al. 2022

Mol. Omics

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“…Ionized serum Ca:Mg 125 and 25(OH)D3 are measures of general health that reflect CRP and HRV 126 . Serum magnesium also reflects gut microbiota diversity and gut health 127,128 .…”

Section: Vitamin D and Ca:mgmentioning

confidence: 99%

Long Covid and Neurodegenerative Disease

Chambers¹

2023

Preprint

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Brain fog with compromised ability to concentrate has been the most frequent Long Covid (LC) complaint. This is due to an increased TGF beta/IFN gamma with consequently increased bradykinin (BKN), especially in Caucasian females. Brain and lung blood vessels “leak.” This same ratio is increased in Alzheimer’s disease (AD), but decreased in Parkinson’s disease (PD), because CD4+ and CD8+ T cells are differentially affected by the invading associated viruses, e.g., SARS CoV2, HIV, …. In Covid-19 CD147 receptors on immune cells are critical in generating the increased TGF beta/IFN gamma and those on endothelial cells, platelets, and erythrocytes are critical to the abnormal microvascular blood flow. ACE2 receptors on pneumocytes and enterocytes enable pulmonary and GI entry, initiating gut dysbiosis. Epigenetics, methylation, magnesium, vitamin D, the B vitamins, and antioxidants suggest that these issues can be surmounted. Biochemical, physiologic, and epidemiologic data are analyzed to answer these questions. An LC model is presented and discussed in the context of the most recent research. Suggestions to avoid these and other worrisome concerns are included. Other topics discussed include estrogen, the gut microbiome, type 2 diabetes (T2D), and homocysteine.

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“…In studies on liver damage caused by methotrexate therapy, it was shown that magnesium Isoglycyrrhizinate (MgIG) changed the composition of the intestinal microbes by increasing the level of probiotic Lactobacillus and reducing the level of Muribaculaceae [ 153 ]. Another study demonstrated that mice on a low-magnesium diet showed a lowered number of Bifidobacterium in the gut and high levels of TNF-α and IL-6 [ 154 ].…”

Section: Micronutrients Gut Microbiome and Cancermentioning

confidence: 99%

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

Frąk

Grenda²,

Krawczyk³

et al. 2022

Cancers

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The effectiveness of immunotherapy in cancer patients depends on the activity of the host’s immune system. The intestinal microbiome is a proven immune system modulator, which plays an important role in the development of many cancers and may affect the effectiveness of anti-cancer therapy. The richness of certain bacteria in the gut microbiome (e.g., Bifidobacterium spp., Akkermanisa muciniphila and Enterococcus hire) improves anti-tumor specific immunity and the response to anti-PD-1 or anti-PD-L1 immunotherapy by activating antigen-presenting cells and cytotoxic T cells within the tumor. Moreover, micronutrients affect directly the activities of the immune system or regulate their function by influencing the composition of the microbiome. Therefore, micronutrients can significantly influence the effectiveness of immunotherapy and the development of immunorelated adverse events. In this review, we describe the relationship between the supply of microelements and the abundance of various bacteria in the intestinal microbiome and the effectiveness of immunotherapy in cancer patients. We also point to the function of the immune system in the case of shifts in the composition of the microbiome and disturbances in the supply of microelements. This may in the future become a therapeutic target supporting the effects of immunotherapy in cancer patients.

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Magnesium Orotate and the Microbiome–Gut–Brain Axis Modulation: New Approaches in Psychological Comorbidities of Gastrointestinal Functional Disorders

Cited by 17 publications

References 83 publications

Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation

Metabolic responses in the cortex and hippocampus induced by Il-15rα mutation

Long Covid and Neurodegenerative Disease

Interactions between Dietary Micronutrients, Composition of the Microbiome and Efficacy of Immunotherapy in Cancer Patients

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