Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis

Wang, Haina; Lu, Mengji; Deng, Ying; Liu, Yinhui; Xin, Wei; Liu, Man; Zhou, Jiaorui; Ma, Hong; Zheng, Peng‐Yuan; Yuan, Jieli; Li, Ming

doi:10.1016/j.nut.2018.11.018

Cited by 86 publications

(80 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As reported previously, certain probiotics containing uricolytic ability can be used to help prevent oxonic acid-induced hyperuricemia in animals (García-Arroyo et al, 2018). Similarly, a potential probiotic has been found that improves fructose-induced hyperuricemia by reducing intestinal inosine (Wang et al, 2019). However, it is still unclear whether gut microbiota plays a role in the occurrence of hyperuricemia.…”

Section: Discussionmentioning

confidence: 85%

“…Previous studies found that gout patients presented with dysregulation of intestinal microbiome, which in turn served as an indicator for gout. Similarly, a potential probiotic was found to improve fructose-induced HUA by reducing intestinal inosine (Shao et al, 2017;Guo et al, 2016;Wang et al, 2019). The findings from these early studies implied that the gut microbiota could be a new target for the treatment of HUA and gout.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

Liu

Ren³

et al. 2020

PeerJ

View full text Add to dashboard Cite

Some studies on the hyperuricemia (HUA) have focused on intestinal bacteria. To better understand the correlation between gut microbiota and HUA, we established a HUA rat model with high-purine diet, and used 16S rRNA genes sequencing to analyze gut microbiota changes in HUA rats. To analyze the potential role played by gut microbiota in HUA, we altered the gut microbiota of HUA rats with antibiotics, and compared the degree of uric acid elevation between HUA and antibiotic-fed HUA rats (Ab+HUA). Finally, we established a recipient rat model, in which we transplanted fecal microbiota of HUA and normal rats into recipient rats. Three weeks later, we compared the uric acid content of recipient rats. As a result, the diversity and abundance of the gut microbiota had changed in HUA rats. The Ab-fed HUA rats had significantly lower uric acid content compared to the HUA rats, and gut microbiota from HUA rats increased uric acid content of recipient rats. The genera Vallitalea, Christensenella and Insolitispirillum may associate with HUA. Our findings highlight the association between gut microbiota and HUA, and the potential role played by gut microbiota in HUA. We hope that this finding will promote the isolation and culture of HUA-related bacteria and orient HUA-related studies from being correlational to mechanistic. These steps will therefore make it possible for us to treat HUA using gut microbiota as the target.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 98%

The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

Liu

Ren³

et al. 2020

PeerJ

View full text Add to dashboard Cite

show abstract

“…Lactobacillus Brevis DM9218, for instance, have been observed to reduce serum uric acid in mice fed a high fructose diet. The mechanism is interesting as it is associated to the degradation of inosine, an intermediate metabolite of uric acid (24). Aside from the uric acid lowering effect, we think that the possible benefit of probiotics in gout might also be considered in light of their anti-inflammatory, anti-cytokine potential (as discussed below), which might target inflammasome activation and the production of IL-1β, the most important inflammatory mediators in gout.…”

Section: Gout and Hyperuricemiamentioning

confidence: 99%

Benefits of Probiotics in Rheumatic Diseases

Oliviero

Spinella

2020

Front. Nutr.

View full text Add to dashboard Cite

Rheumatic diseases are chronic conditions which affect a large proportion of the population worldwide (1). Among them, inflammatory chronic diseases including rheumatoid arthritis (RA), spondyloarthritis (SpA), crystal-induced arthritis (CIA), and connective tissue autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are the most common. Chronic inflammation has been recognized to play a role also in osteoarthritis (OA), classically considered a non-inflammatory form of arthritis. Although different risk factors influence their onset and development, these heterogeneous conditions share common clinical outcome including joint pain, disability, and comorbidities (2). Over the last years increasing attention have been paid to the role of diet in the pathogenesis and progression of rheumatic diseases. It has been observed that healthy dietary habits and the consumption of foods rich in bioactive compounds, omega-3 fatty acids, and antioxidants are associated with a lower risk to develop these diseases and a less severe clinical outcome (3). In particular, an important link between gut microbiota and patients' clinical features highlighted the possibility to modulate disease progression and presentation through microbiota manipulation. In this setting, an emerging role might be attributed to probiotics, live microorganisms that, when administered in adequate amounts, confer a health benefit on the host (4). The most commonly used are Lactobacilli (L.), Bifidobacteria (B.), and Streptococci (S.), either as single species or in mixed culture. Their health effects are largely recognized and supported by randomized controlled clinical trials (RCTs) and meta-analyses conducted on infectious diseases, antibiotic-associated diarrhea, irritable bowel syndrome, abdominal pain, and colitis (5, 6).

show abstract

“…Probiotics can help maintain or restore the balance of the intestinal microbiome and, consequently, improve the immune system’s response against aggression to the human organism [ 50 ]. Among the mechanisms of probiotics that corroborate with intestinal and systemic health is the competition with pathogenic microorganisms for adhesion sites and nutritional sources, the secretion of antimicrobial peptides, the action of metabolites, nucleosidase activity, and even immunomodulation by signaling pathways of intestinal and immune cells [ 51 , 52 , 53 , 54 , 55 , 56 ].…”

Section: Introductionmentioning

confidence: 99%

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

et al. 2020

View full text Add to dashboard Cite

Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.

show abstract

Lactobacillus brevis DM9218 ameliorates fructose-induced hyperuricemia through inosine degradation and manipulation of intestinal dysbiosis

Cited by 86 publications

References 54 publications

The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

The altered gut microbiota of high-purine-induced hyperuricemia rats and its correlation with hyperuricemia

Benefits of Probiotics in Rheumatic Diseases

Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Contact Info

Product

Resources

About