Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Morais, Ana Heloneida de Araújo; Passos, Thaís Souza; Maciel, Bruna Leal Lima; Silva-Maia, Juliana Kelly da

doi:10.3390/nu12061737

Cited by 60 publications

(56 citation statements)

References 140 publications

(234 reference statements)

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“…In this context, Morais et al (134) through a narrative review highlighted the use of Lactobacillus gasseri in association with a diet rich in vitamins, minerals and bioactive compounds as an additional nutritional therapy to promote the immune system against viral infections, as in the case of SARS-CoV-2 infection, especially in patients with hyperuricaemia. This critical action of probiotics, especially L. gasseri, occurs because the microorganisms act on purine metabolism, reducing the availability of purine nucleotides for viral RNA and DNA synthesis.…”

Section: Probioticsmentioning

confidence: 99%

Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2

et al. 2020

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COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was recognized by the World Health Organization (WHO) as a pandemic in 2020. Host preparation to combat the virus is an important strategy to avoid COVID-19 severity. Thus, the relationship between eating habits, nutritional status, and their effects on the immune response and further implications in viral respiratory infections are important topics discussed in this revision. Malnutrition causes the most diverse alterations in the immune system, suppressing of the immune response and increasing the susceptibility to infections as SARS-CoV-2. On the other hand, obesity induces low-grade chronic inflammation caused by excess adiposity, which increases angiotensin-converting enzyme 2 (ACE2). It decreases the immune response favoring SARS-CoV-2 virulence and promoting respiratory distress syndrome. The present review highlights the importance of food choices considering their inflammatory effects, consequently increasing the viral susceptibility observed in malnutrition and obesity. Healthy eating habits, micronutrients, bioactive compounds, and probiotics are strategies for COVID-19 prevention. Therefore, a diversified and balanced diet can contribute to the improvement of the immune response to viral infections such as COVID-19.

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Section: Probioticsmentioning

confidence: 99%

Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2

et al. 2020

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“…A Narrative Review Review [ 162 ] 7 The small intestine, an underestimated site of SARS-CoV-2 infection: from Red Queen effect to probiotics Review [ 60 ] 8 Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles Review [ 163 ] 9 Antiviral effects of probiotic metabolites on COVID-19 Express Communication [ 164 ] 10 Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 Pandemic Review [ 165 ] 11 Nutrition Therapy in Critically Ill Patients With Coronavirus Disease 2019 Review [ 166 ] 12 Approach to Nutrition in Cancer Patients in the Context of the Coronavirus Disease 2019 (COVID-19) Pandemic: Perspectives Review [ 167 ] 13 Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review Review [ 168 ] 14 Dietary recommendations during the COVID-19 pandemic Review [ 169 ] 15 Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection? Review [ 170 ] 16 Should Probiotics, honey, and escin be used in the prevention or treatment of COVID-19? Review [ …”

Section: Recent Evidence Of Probiotics In Covid-19 - Preclinical and mentioning

confidence: 99%

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

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Mazhar

Waseem

et al. 2021

Biomedicine & Pharmacotherapy

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“…Jayawardena et al (83) suggested the use of probiotics as a dietary supplement to prevent infection of susceptible populations with SARS-CoV-2. Since probiotics are readily available as dietary supplements and have negligible side-effects if administered at the correct doses, they may thus provide a useful intervention strategy against COVID-19 (84)(85)(86). A study to evaluate whether dietary supplementation with Lactobacillus coryniformis K8 can help to prevent healthcare workers from contracting COVID-19 was registered at ClinicalTrials.gov (NCT04366180) on April 28, 2020.…”

Section: Amino Acidsmentioning

confidence: 99%

Nutraceuticals and herbal extracts: A ray of hope for COVID‑19 and related infections (Review)

2020

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The global pandemic caused by the novel coronavirus disease 2019 (COVID-19), for which there is no effective vaccine or treatment available yet, has led to a global health emergency. Despite a lack of clinical data, compelling evidence from the literature suggests that certain nutraceuticals (such as omega-3 fats, β-glucans, amino acids, probiotics, vitamins and minerals) and plant-based compounds derived from herbal extracts may potentially be used in the treatment of COVID-19. In the present review article, the benefits of such natural products in treating various respiratory complications are highlighted, and it is tentatively suggested that these benefits could be extrapolated to COVID-19. These natural compounds may not only modulate the immunity of a susceptible population, but may also pave the way towards the development of drugs which may be used to treat COVID-19. Although attention has recently focused on these compounds in this context, further clinical and experimental studies are required to validate their efficacy. It is thus suggested that the in vitro and in vivo evaluation of these compounds be carried out as soon as possible, in order to counteract the ongoing increase in the number of cases of COVID-19. Contents 1. Introduction 2. Therapeutic benefits of nutraceuticals for respiratory complications 3. Therapeutic benefits of herbal extracts for respiratory complications 4. Conclusion Prevention and treatment of COVID-19. As of August 5, 2020, no vaccine or successful treatment for COVID-19 has been reported and only supportive care, personal protection, early diagnosis and isolation are available to reduce the spread and severity of the infection (5). Huang et al (6) reported that patients with COVID-19 develop acute respiratory distress syndrome, followed by anemia, acute heart injuries and secondary infections. Empirical therapy with antibiotics (including cephalosporins, azithromycin, vancomycin, quinolones, tigecycline and carbapenems), antivirals (including lopinavir, ritonavir, remdesivir and oseltamivir) and corticosteroids (including dexamethasone and methylprednisolone) has thus been used for the treatment of patients with COVID-19 (7). The clinical efficacy of all of these treatments, however, warrants further confirmation. Potential agents with which to combat COVID-19. Research proposals and clinical trials have suggested that some treatments, including supplements and phytochemicals, have the potential to help fight coronavirus infection. A recent study suggested that the risk of becoming infected could be reduced by vitamin D3 supplementation. Serum concentrations >40-60 ng/ml (100-150 nmol/l) were suggested to be

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Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?

Cited by 60 publications

References 140 publications

Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2

Nutritional status, diet and viral respiratory infections: perspectives for severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

Nutraceuticals and herbal extracts: A ray of hope for COVID‑19 and related infections (Review)

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