Lactase non-persistence and milk consumption in Estonia

Lember, Margus; Torniainen, Suvi; Kull, Mart; Kallikorm, Riina; Saadla, Peeter; Rajasalu, Tarvo; Komu, Hanna; Järvelä, Irma

doi:10.3748/wjg.v12.i45.7329

Cited by 43 publications

(24 citation statements)

References 20 publications

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“…[17] However, most people with the established genotype C/C-13910 consumed 100 to 250 ml of fresh milk a day (Equivalent to an intake of 12.5 gm of galactose) without milk intolerance. [13,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The majority of Uzbeks tolerate the use of dairy products, regardless of affiliation to the genotype of C/C or C/T-13910(p> 0.05) and use dairy products like katik(yogurt) and suyzma(curd) daily or several times a week.…”

Section: Resultsmentioning

confidence: 99%

A Single Nucleotide Polymorphism C/T - 13910 and Consumption of Dairy Products in Uzbek Population

Kasimov¹,

Nazarova²,

Kasimova³

et al. 2015

jemds

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AIM: To determine the relationship between C/C-13910 genotyping and consumption of dairy products in an Uzbek population and to study the incidence of gastrointestinal symptoms for dairy products in the LNP C/C-13910 carriers. METHODS: 100 Uzbeks were examined for nucleotide polymorphisms by polymerase chain reaction/restriction fragment length polymorphism. Dairy tolerance was analyzed by a questionnaire, developed to assess dyspepsia after milk and dairy consumption. RESULTS: The genetic allele variant C/C-13910, the marker of lactase non-persistence, was found in 81% of cases in the Uzbek population. In 19% of the subjects, the genotype C/T-13910 was found. No statistically significant relationship was found between the lactase deficiency genotype and consumption of dairy products (p>0,05). The majority of the participants with the genotype C/C-13910 were reported to consume dairy products every day or several times in week. Among carriers of genotype LNP gastrointestinal symptoms, when consuming dairy products, do not occur more often than in those with genotype LP (p>0.05). CONCLUSION: Despite the high prevalence of lactase deficiency in the Uzbek population, Uzbeks tolerate dairy products well and regularly consume them. Regular consumption of fermented milk products in the diet of the Uzbek population is likely to compensate for the rare use of milk and helps with the intake of calcium and other nutrients contained in milk.

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Section: Resultsmentioning

confidence: 99%

A Single Nucleotide Polymorphism C/T - 13910 and Consumption of Dairy Products in Uzbek Population

Kasimov¹,

Nazarova²,

Kasimova³

et al. 2015

jemds

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“…Importantly, genotyping is a minimally invasive method and the results of the tests are available quickly [19,20].…”

Section: Discussionmentioning

confidence: 99%

“…The assessment of milk intolerance symptoms combined with the testing for C/T-13910 SNP variants are considered reliable methods to determine a diagnosis of hypolactasia [19,24].…”

Section: Discussionmentioning

confidence: 99%

Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan

Kasimov¹,

Lember²

2013

IJNFS

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Abstract:Objective: To determine the prevalence of adult-type hypolactasia in the Tajik population living in the south of Uzbekistan by genotyping of allelic variants C/T-13910 and identifying their tolerance to milk. Methods: 100 ethnic Tajik adults were examined for C/T-13910 single nucleotide polymorphisms using polymerase chain reaction/restriction fragment length polymorphism. Milk tolerance was analyzed by a questionnaire developed to assess dyspepsia after milk and dairy consumption. Results: A genetic marker of hypolactasia -C/C-13910 genotype was detected in 83% of the adult Tajik population. However, despite the high prevalence of lactose intolerance in the Tajik population, the majority consume between 100-200 ml of milk per day. Conclusion: The Tajik population is characterized by a high prevalence of hypolactasia. Milk consumption is not affected by the determined genotypes since people of Tajik ethnicity consume milk in small quantities.

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“…рис. 2, в), ранее выявленный с низкой частотой в популяциях различных регионов (Эстония, Индия, Пакистан, Бразилия) (Lember et al, 2006;Friedrich et al, 2012;Gallego et al, 2012).…”

Section: результатыunclassified

Polymorphism of the LCT gene regulatory region in Turkicspeaking populations of the Altay-Sayan region (southern Siberia)

Pilipenko¹,

Pristyazhnyuk²,

Кобзев³

et al. 2016

Vestn. VOGiS

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Retention of lactase activity in adulthood (lactase persistence) is one of the most important adaptive traits for human populations that consume fresh milk from domestic animals. At a molecular-genetic level, lactase persistence is determined by the presence of specific alleles of polymorphic sites in cis-regulatory elements of the LCT gene located on chromosome 2q21. Ascertainment of the molecular-genetic causes of lactase persistence has made this trait one of the most convenient for studying mechanisms of human population adaptation to environmental conditions. But the populations of many regions remain insufficiently investigated in relation to the genetic variability of the LCT loci. This paper presents the results of polymorphism analysis of loci, including the enhancer element for the LCT gene and its flanking regions, in two Turkic-speaking populations from southern Siberia, Altaian Kazakhs and Khakasses. It was found that the "European" allele LCT-13910T is the most characteristic of the Turkic-speaking populations from Altai-Sayan regions among all the polymorphic variants associated with lactase persistence. The expansion of the "European" allele LCT-13910T to the gene pool of the populations in southern Siberia could be related to migration waves of ancient herders form western Eurasia during the Bronze Age (in III -II millennium BC). A decrease of the LCT-13910T allele frequency and the total frequency of its carriers in the Turkic-speaking populations of southern Siberia in comparison with the majority of European populations Сохранение активности фермента лактазы во взрослом возрасте (персистенция лактазы) является одним из важных адаптативно значимых признаков для популяций человека, потребляющих в пищу свежее молоко домашних животных. На молекулярно-генетическом уровне персистенция лактазы детерминируется наличием специфических аллельных вариантов ряда полиморф-ных позиций в цис-регуляторных элементах гена LCT, расположен-ного на хромосоме 2q21. Установление молекулярно-генетических причин персистенции лактазы сделало этот признак одной из удобных моделей для изучения механизмов адаптации популяций человека к условиям среды. Население многих регионов остается недостаточно исследованным в отношении генетической вариа-бельности этого локуса. В данной работе приведены результаты анализа полиморфизма локуса, включающего в себя энхансерный элемент гена LCT и фланкирующие его районы, в двух тюркоязыч-ных группах населения Южной Сибири -алтайских казахов и хака-сов. Показано, что для тюркоязычного населения Алтае-Саянского региона из всех полиморфных вариантов, ассоциированных с персистенцией лактазы, наиболее характерным является «евро-пейский» аллель LCT-13910T. Проникновение «европейского» аллеля LCT-13910T в генофонд населения Южной Сибири могло быть связано с миграционными волнами древних популяций животноводов Западной Евразии в Южную Сибирь в эпоху бронзы (III-II тысячелетия до н. э.). Снижение частоты аллеля LCT-13910T и суммарной частоты его носителей у тюркоязычных популяций Южной Сибири по с...

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Lactase non-persistence and milk consumption in Estonia

Cited by 43 publications

References 20 publications

A Single Nucleotide Polymorphism C/T - 13910 and Consumption of Dairy Products in Uzbek Population

A Single Nucleotide Polymorphism C/T - 13910 and Consumption of Dairy Products in Uzbek Population

Milk Consumption is Not Affected by C/T-13910 Single Nucleotide Polymorphism in a Tajik Population in a Southern Region of Uzbekistan

Polymorphism of the LCT gene regulatory region in Turkicspeaking populations of the Altay-Sayan region (southern Siberia)

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