Lack of responsiveness to glucose of microencapsulated islets of Langerhans after three weeks' implantation in the rat—influence of the complement

Gin, H.; Dupuy, B.; Baquey, A.; Baquey, C.; Ducassou, D.

doi:10.3109/02652049009021844

Cited by 26 publications

(11 citation statements)

References 14 publications

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“…Several groups have performed xcnotransplantation of microencapsulated islets in alginate-poly-L-lysine, and an important fibrosis reaction around the capsule was observed, probably due to the use of poly-i_-lysine, which is not biocompatible. and to the fragility of the capsules prepared with this procedure (8).…”

Section: Jesser El' a Lmentioning

confidence: 99%

Pancreatic Islet Macroencapsulation: A New Device for the Evaluation of Artificial Membrane

Jesser¹,

Kessler²,

Lambert

et al. 1996

Artificial Organs

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We propose a new device especially designed to test membranes for islet macroencapsulation. It is composed of three independent parts: a support made of three polytetrafluoroethylene rings, the membrane that forms the walls of the encapsulation chamber, and a collagen gel that immobilizes the islets. Studies of this device were performed with the AN69 membrane. After 2 months of implantation in the peritoneal cavity of rats, the empty device was found to be biocompatible, referred to as weak cellular adhesion. In vitro the encapsulation preserved the peak of insulin release in response to high glucose during a perifusion test (0.36 +/- 0.02 microU/ml/islet for free or encapsulated islets). As a result of the collagen gel, the morphological aspect and functional activity were still preserved after 7 days of culture. In vivo xenotransplantation into diabetic mice normalized the fasting glycemia up to 30 days. Numerous macrophages adhered to the outer surface of the membrane, and a layer of cells emerging from the destruction of islets covered the inner surface. In addition, the morphological aspect of many islets was altered. By showing that the AN69 membrane was only partially efficient for islet xenotransplantation, this new device proved to be of interest for testing a variety of membranes.

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Section: Jesser El' a Lmentioning

confidence: 99%

Pancreatic Islet Macroencapsulation: A New Device for the Evaluation of Artificial Membrane

Jesser¹,

Kessler²,

Lambert

et al. 1996

Artificial Organs

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“…A wide and diverse range of polymer compositions have been used to fabricate hydrogels; Table 1 summarizes the many varied compositions. The compositions can be classified into natural polymer hydrogels,21–30 synthetic polymer hydrogels,31–38 and combinations of the two classes 39–44. Many different routes have been used to synthesize hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels for Biomedical Applications

Hoffman

2001

Annals of the New York Academy of Sciences

1,143

1,306

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“…[52] A new approach of designing was made by yannas and co-workers in 1980s using hydrogels containing naturally occurring polymers like shark cartilage and collagen. [54,55] For the process of cell encapsulation hydrogels of natural and synthetic source have been continuously used. [56][57][58][59] In the field of tissue engineering, these hydrogels have been used for reforming various organs and tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Complex coacervates and polyelectrolytes complexes are formed by crosslinking of ionic system. Calcium alginate capsules were stabilized using alginate poly (L-lysine) PPL by Lim and Sun [54] in the field of tissue engineering polyion hydrogels and coacervates have been successfully used. Often, physical gels can be formed by using combination of polymeric biotin and avidin, [70] or polymeric sugar and conavalin.…”

Section: Introductionmentioning

confidence: 99%

Insight into hydrogels

Khan

Ullah

et al. 2016

Designed Monomers and Polymers

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The development and introduction of injectable biomaterials and the identification of methods through which materials may form in situ are currently the topics of interest in materials science, specifically in the field of biomaterials. Over the last few decades, hydrogels which refers to the swellable polymeric matrices have gained wide attention due to their excellent characteristics such as swelling in different media, pH and temperature sensitivity, and sensitivity to other stimuli. Nowadays, injectable hydrogels have widely been studied due to their excellent insitu gelation at body temperature. These injectable insitu gels serve as depot system which ensures the local and systemic drug and gene delivery. These insitu gels also protect the proteins and peptide drugs invivo from environmental effect. The current review is made to report latest extensive literature regarding hydrogels, their classification, synthesis methods, structure of hydrogel network, methods of crosslinking, environment-sensitive hydrogel system, drug loading, and release, hydrogels as biosensors and applications of hydrogels.

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Lack of responsiveness to glucose of microencapsulated islets of Langerhans after three weeks' implantation in the rat—influence of the complement

Cited by 26 publications

References 14 publications

Pancreatic Islet Macroencapsulation: A New Device for the Evaluation of Artificial Membrane

Pancreatic Islet Macroencapsulation: A New Device for the Evaluation of Artificial Membrane

Hydrogels for Biomedical Applications

Insight into hydrogels

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