Lack of production response in grazing dairy cows supplemented withlong-acting injectable vitamin B<sub>12</sub>

Grace, N. D.; Knowles, Scott O.

doi:10.1080/00480169.2011.639932

Cited by 13 publications

(3 citation statements)

References 24 publications

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“…Vitamin B 12 is synthesised by rumen microorganisms in the presence of cobalt in ruminants. Diet composition is also an important factor in the synthesis of Vitamin B 12 by microorganisms (Grace & Knowles, 2012 ). Vitamin B 12 also affects the function of enzymes affecting lipid metabolism, which may be why Vitamin B 12 deficiency may alter lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

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Section: Discussionmentioning

confidence: 99%

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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“…[27][28][29][30] Secondly, the upscaling of meat production to satisfy increasing planetary demands has led to live-stock being husbanded under conditions wherein supplementation with either cobalt (to supply rumen microbes with the metal for B 12 biosynthesis) or with parenteral vitamin B 12 (to treat cobalt deficiency) are necessary for their own health and growth. [31][32][33][34] This requirement appears to be linked to unnatural feeding conditions typical of intensive animal agriculture, as free grazing animals do not have a need for supplementation with vitamin B 12 . 34 Thirdly, the high demand for meat on the planet does not permit the feeding of all humans with free-ranging grazing animals.…”

Section: The Challenge Of Acquiring Enough Vitamin B 12 In the Era Of...mentioning

confidence: 99%

“…[31][32][33][34] This requirement appears to be linked to unnatural feeding conditions typical of intensive animal agriculture, as free grazing animals do not have a need for supplementation with vitamin B 12 . 34 Thirdly, the high demand for meat on the planet does not permit the feeding of all humans with free-ranging grazing animals. Since the transition toward plant-based diets that are devoid of B 12 is unavoidable, every effort should be made to prevent B 12 deficiency in vegetarians and vegans.…”

Section: The Challenge Of Acquiring Enough Vitamin B 12 In the Era Of...mentioning

confidence: 99%

Vitamin B₁₂ Status and Supplementation in Plant-Based Diets

Hannibal,

Lederer,

Storz

et al. 2024

Food Nutr Bull

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Plant-based diets are increasingly popular worldwide. A well-planned plant-based diet lowers the risk of cardiovascular disease, type 2 diabetes and certain cancers. In contrast, a poorly planned plant-based diet increases the risk of certain micronutrient deficiencies, chiefly, vitamin B12 (B12). Because B12 is not present in plants or in unfortified plant-based foodstuffs, the safest way to prevent its deficiency in plant-based diets is to take an oral B12 supplement. Studies determining the dose and frequency of B12 to be taken by healthy individuals on a plant-based diet to support an adequate B12 status are scarce. Here, we summarize the natural sources, metabolic requirements, biomarker findings with and without supplementation with B12, and current recommendations to help prevent vitamin B12 deficiency in healthy individuals adhering or transitioning to plant-based diets. This review focuses on the prevention of vitamin B12 deficiency in healthy individuals adhering to plant-based diets. The information covered in this review does not apply to individuals suffering from autoimmune-based malabsorption of vitamin B12 resulting from pernicious anemia due to atrophic gastritis, other acquired causes of B12 malabsorption or to those with genetic disorders that impair vitamin B12 absorption, transport and utilization.

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Diseases of the Hemolymphatic and Immune Systems

2017

Veterinary Medicine

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Lack of production response in grazing dairy cows supplemented withlong-acting injectable vitamin B₁₂

Abstract: Long-acting injectable vitamin B₁₂ used to treat and prevent vitamin B₁₂ deficiency is unlikely to improve the milk production of grazing cows when concentrations of vitamin B₁₂ in serum are >128 pmol/L.

Cited by 13 publications

References 24 publications

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Vitamin B₁₂ Status and Supplementation in Plant-Based Diets

Diseases of the Hemolymphatic and Immune Systems

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Lack of production response in grazing dairy cows supplemented withlong-acting injectable vitamin B12

Abstract: Long-acting injectable vitamin B₁₂ used to treat and prevent vitamin B₁₂ deficiency is unlikely to improve the milk production of grazing cows when concentrations of vitamin B₁₂ in serum are >128 pmol/L.

Cited by 13 publications

References 24 publications

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Vitamin B12 Status and Supplementation in Plant-Based Diets

Diseases of the Hemolymphatic and Immune Systems

Contact Info

Product

Resources

About

Lack of production response in grazing dairy cows supplemented withlong-acting injectable vitamin B₁₂

Vitamin B₁₂ Status and Supplementation in Plant-Based Diets