Lack of Hyperlipidemia in Carpal Tunnel Syndrome

Bischoff, Christian; Isenberg, C.; Conrad, B.

doi:10.1159/000116642

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…Bischoff et al . in a case-control study, found no significant difference in the serum LDL-C between patients with CTS and healthy individuals, which is in line with our study [ 21 ]. On the other hand, Yeo et al .…”

Section: Discussionsupporting

confidence: 93%

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The relationship of serum lipid profiles and obesity with the severity of carpal tunnel syndrome

2021

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Introduction Carpal tunnel syndrome (CTS) is a prominent compressive neuropathy. There are a number of risk factors for creating CTS but the effect of these factors on the severity of CTS is unclear. In this study, we aimed to assess the correlation of serum lipid profile and obesity with the severity of CTS. Methods this cross-sectional study was conducted on 118 patients with idiopathic CTS. Blood samples were obtained for determining the serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) after 12 hours of overnight fasting. The participants were then divided into two groups of normal and abnormal serum lipids. Body mass index ≥ 30 kg/m 2 was considered as obesity. The severity of CTS was determined based on the electrophysiological results and Boston CTS Questionnaire (BCTSQ) that evaluates symptoms severity (SSS) and functional status (FSS) of patients. Results out of 118 participants, 108 patients performed lipid profile test that 41.17%, 50.42%, 25.21%, and 20.16% of them had TC ≥ 200, TG ≥ 150, LDL-C ≥ 130, and HDL-C < 60 milligrams per deciliter (mg/dl), respectively. The mean scores of SSS in patients with dyslipidemia including the high level of TC, TG, LDL-C, and low level of LDL-C were 34.59±7.86, 34.05±8.73, 34.93±8.21, and 33.48±7.56, respectively. There was no significant association between lipid profile and the symptom severity scale of CTS (p-value > 0.05). The mean BMI of participants was 31.35±5.35 kg/m 2 , and 58.5% of them had a BMI ≥ 30 kg/m 2 . The mean score of SSS and FSS was 33.18±8.24 and 24.43±7.12 in obese patients (BMI ≥ 30 kg/m 2 ), and was 34.06±7.85 and 23.06±7.67 in patients with BMI < 30 kg/m 2 . We found no significant association between obesity with the SSS and FSS (p-value = 0.53 and 0.32, respectively). In terms of the relationship between electrophysiological grading with obesity, 44 (63.8%) of patients with BMI ≥ 30 kg/m 2 and 22 (45.8%) patients with BMI < 30 kg/m 2 had severe to extreme severe CTS. There was no significant association between obesity and the severity of CTS (p-value = 0.054). Conclusion the results of this study did not demonstrate an association between serum lipid profile and obesity with the severity of carpal tunnel syndrome. The findings of this study may not be extrapolated to other populations. Further studies with more samples are needed to investigate this association.

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Section: Discussionsupporting

confidence: 93%

“…However, it is unclear the effect of lipid profile on the severity of CTS [ 16 ]. On the other hand, some studies described no correlation between hyperlipidemia and CTS [ 21 , 22 ]. Therefore, the purpose of the current study was to evaluate the correlation of serum lipid profile and BMI with the severity of CTS.…”

Section: Introductionmentioning

confidence: 99%

The relationship of serum lipid profiles and obesity with the severity of carpal tunnel syndrome

2021

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“…High triglyceride and low HDL levels were not considered risk factors. Bischoff et al1 have performed serum lipid comparisons in a case‐control study of patients with CTS and found no difference in LDL. The reason for this difference is unclear, but two points regarding their study design may be responsible: (1) their patients, aged 18–76 (mean, 43) years, were young for the typical population of idiopathic CTS; and (2) 40% of them had had CTS for more than 1 year up to 10 years, so that the serum lipid values might have differed from those at around the onset of CTS.…”

Section: Discussionmentioning

confidence: 99%

Hypercholesterolemia as a risk factor for idiopathic carpal tunnel syndrome

Nakamichi

Tachibana

2005

Muscle and Nerve

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In idiopathic carpal tunnel syndrome (CTS), the median nerve is enlarged within the carpal tunnel due to intraneural connective tissue proliferation. Because hypercholesterolemia, especially increase in low-density lipoprotein (LDL), has been associated with fibrogenesis, we investigated the association of median nerve cross-sectional area and prevalence of idiopathic CTS with serum lipid measurements in middle-aged patients and controls. We found that nerve area and prevalence of CTS were correlated with serum LDL levels. Thus, high LDL levels in middle age are a risk factor for idiopathic CTS, suggesting that the LDL-correlated median nerve enlargement increases the volume of the carpal tunnel contents.

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“…Although it is logical that obesity and obesity-related dyslipidemia, such as increased LDL cholesterol and triglycerides, may be linked to CTS, as demonstrated by Shiri et al, 5 another study also documented higher HDL cholesterol in patients with CTS. 35 Our study has several limitations, most notably its small sample size. Moreover, the investigation was cross-sectional in nature, and therefore our results cannot implicate causality.…”

Section: 415mentioning

confidence: 90%