Lack of effect of Timothy grass pollen sublingual immunotherapy tablet on birch pollen–induced allergic rhinoconjunctivitis in an environmental exposure unit

Ellis, Anne K.; Tenn, Mark W.; Steacy, Lisa M.; Adams, Daniel E.; Day, Andrew G.; Walker, Terry; Nolte, Hendrik

doi:10.1016/j.anai.2018.02.003

Cited by 27 publications

(15 citation statements)

References 20 publications

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“…We also found a trend in the reduction of SPT reactivity toward birch, possibly suggesting that immunomodulation taking place upon SLIT may have a general tolerance‐inducing bystander effect, also on other off‐target allergens. However, a pilot study of bystander effects of a 4‐month treatment with P. pratense SLIT tablet Grastek ® could not prove any effect on birch‐induced allergic rhinitis in adults with both birch and grass pollen allergy …”

Section: Discussionmentioning

confidence: 96%

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Huoman

Papapavlou

Pap

et al. 2019

Pediatric Allergy Immunology

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Background: Immunomodulatory effects of sublingual immunotherapy on systemic and mucosal mediators in allergic children are largely unexplored. The aim of this study was to investigate allergy-related cytokine and chemokine levels, as well as IgA-responses upon a 3-year treatment with timothy grass pollen sublingual immunotherapy in children with allergic rhinoconjunctivitis.Methods: From children included in the GRAZAX ® Asthma Prevention study, blood and saliva samples were analyzed at inclusion, after 3 years of treatment, and 2 years after treatment ending. By means of Luminex and ELISA methodologies, allergy-related cytokines and chemokines were measured in plasma samples and allergen-stimulated peripheral blood mononuclear cell supernatants. Furthermore, studies of total, secretory, and Phl p 1-specific salivary IgA antibodies were performed using the same methods.Results: GRAZAX ® -treated children exhibited significantly higher levels of Phl p 1specific salivary IgA and serum IgG 4 , along with significantly lower skin prick test positivity, after 3 years of treatment and 2 years after treatment cessation.Additionally, plasma levels of the Th1-associated chemokines CXCL10 and CXCL11 were significantly higher in treated than untreated children at these time points.Timothy-induced ratios of IL-5/IL-13 over IFN-γ were significantly decreased after 3 years with active treatment, as were symptoms of allergic rhinitis in terms of both severity and visual analogue scale scores. However, no consistent correlations were found between the clinical outcomes and immunologic parameters. Conclusion: Phleum pratense sublingual immunotherapy in grass pollen allergic children modulates the immune response in the oral mucosa as well as systemically-by increasing Th1-responses, decreasing Th2-responses, and inducing immunoregulatory responses-all signs of tolerance induction. | 523 HUOMAN et Al.

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Section: Discussionmentioning

confidence: 96%

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Huoman

Papapavlou

Pap

et al. 2019

Pediatric Allergy Immunology

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“…12 However, a bystander effect on other pollen allergies outside the tree-homologous group cannot be expected. 28 It is noteworthy that the treatment effect was driven by a simultaneous improvement in symptoms and a reduction in the need for symptom-relieving medication. During the trial, subjects had free access to pharmacotherapy in addition to the investigational medication.…”

Section: Discussionmentioning

confidence: 99%

The SQ tree SLIT-tablet is highly effective and well tolerated: Results from a randomized, double-blind, placebo-controlled phase III trial

Biedermann

Kuna

Panzner

et al. 2019

Journal of Allergy and Clinical Immunology

101

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placebo treatment. The primary end point was the average daily ARC total combined score (TCS) during the birch pollen season (BPS) analyzed for subjects with diary data during the BPS. Secondary end points included average daily symptom scores (DSS) during the BPS, average TCS and DSS during the tree pollen season (TPS), and average daily medication scores (DMS) in the BPS and TPS. Results: The primary and key secondary end points demonstrated statistically significant and clinically relevant effects of the SQ tree SLIT-tablet compared with placebo. For the BPS, absolute (relative) differences from placebo were 3.02 (40%) for TCS, 1.32 (37%) for DSS, and 1.58 (49%) for DMS (all P < .0001). For the TPS, absolute (relative) differences from placebo were 2.27 (37%) for TCS, 0.99 (33%) for DSS, and 1.20 (47%) for DMS (all P < .0001). Treatment was well tolerated. The most frequently reported treatment-related adverse events were mild or moderate local reactions related to sublingual administration. Conclusion: The trial demonstrated the efficacy and safety of the SQ tree SLIT-tablet compared with placebo during the BPS and TPS in adolescents and adults with birch pollen-induced

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“…AIT of pollens in children aims to reduce rhinoconjunctivitis and asthma during and after AIT discontinuation. In the last years, extensive clinical trials programs performed in adults and children with sublingual tablets have allowed to establish that the effect (around 30% reduction in symptoms and medication scores) is similar in both age groups, that it is allergen‐specific, and that a vaccine with a particular allergen has no clinical effect in allergic symptoms caused by unrelated species . There is as well clinical evidence on the tolerability of two simultaneous vaccines .…”

Section: Prescribing Immunotherapy To Pollens In Children: Influencmentioning

confidence: 99%

Allergen Immunotherapy in Children User’s Guide

Alvaro‐Lozano

Akdiş

Alviani

et al. 2020

Pediatric Allergy Immunology

225

240

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Aim and scopePediatric Allergy and Immunology publishes original contributions and comprehensive reviews related to the understanding and treatment of immune defi ciency, allergic infl ammatory and infectious diseases in children. Other areas of interest include development of specifi c and accessory immunity, and the immunological interaction during pregnancy and lactation between mother and child. As the journal is intended to promote communication between scientists engaged in basic research and clinicians working with children, both clinical and experimental work will be published.

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Lack of effect of Timothy grass pollen sublingual immunotherapy tablet on birch pollen–induced allergic rhinoconjunctivitis in an environmental exposure unit

Cited by 27 publications

References 20 publications

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

Sublingual immunotherapy alters salivary IgA and systemic immune mediators in timothy allergic children

The SQ tree SLIT-tablet is highly effective and well tolerated: Results from a randomized, double-blind, placebo-controlled phase III trial

Allergen Immunotherapy in Children User’s Guide

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