Lack of effect of dimethyl sulphoxide (DMSO) on amyloid deposits in lichen amyloidosis

Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis

“…The rapid clinical improvement, in contrast with the persistence of amyloid deposits in the histopathologic sections, could not be explained by a possible amyloid‐dissolving effect. In an in vitro study by Lim et al 24 . no decrease in amyloid deposits could be obtained in the Congo‐red‐stained histopathologic sections of punch biopsy material from an LA patient when incubated with pure DMSO for 3, 5, and 7 days.…”

532‐nm and 1064‐nm Q‐switched Nd:YAG laser therapy for reduction of pigmentation in macular amyloidosis patches

“…Calcipotriol or phototherapy are similarly of limited use 11,12 . There have been reports of response to topical DMSO therapy in some cases, but in the contrary, there are other reports that show the lack of efficacy of topical DMSO on amyloid deposit in primary amyloidosis 13,14 . Etretinate or acitretin therapy has been beneficial in a proportion of, 15,16 but not all, patients; 17 the condition soon relapses after the etretinate is stopped 17 .…”

A case of lichen amyloidosis treated with pulsed dye laser

“…Topical application of corticosteroids is probably selected by many dermatologists but frequently provides a poor result. Topical dimethyl sulphoxide therapy has been advocated 3 but has shown little effect on established amyloid deposits 4 . The effectiveness of topical calcipotriol ointment has been reported recently 5 .…”