Intermittent use of topical dimethyl sulfoxide in macular and papular amyloidosis

Abstract

Locally applied DMSO can break the vicious "pruritus-amyloid deposition-pruritus" cycle in patients with MA and LA. In addition to its daily use, interval therapy seems to maintain this effect and enables patients to tolerate side-effects more easily.

Lichen Amyloidosis; Evaluation of the Efficacy of Topical Dimethyl Sulfoxide (D.M.S.O) 70% in Abbasi Shaheed Hospital, Karachi

“…Our results are comparable with two studies by the same researchers done at Turkey showing the efficacy of 72% (intermittent use of D.M.S.O 50%) 11 and 90% (daily use of D.M.S.O 50%).…”

“…1,2,9 Clinically Lichen amyloidosis (L.A) presents as closely set, discrete, brownred hyperkeratotic papules or plaques with slight scaling which are intensely itchy, located more commonly on the trunk or extremities especially the shins. 11 and 90% (daily use of D.M.S.O 50%). 13 These studies were done in 1997 and 1998, and no study was conducted after that.…”

Clinicoepidemiological and histopathological study of cutaneous amyloidosis with histopathological correlation

“…6 Ozkaya-Bayazit et al observed that majority of the patients of cutaneous amyloidosis belonged to the age group 41-50 years (38.46%), Macular amyloidosis was seen mostly in the age group of 41-50 years (40%). 9 In the present study of 50 patients of cutaneous amyloidosis, 17 were males (34%) and 33 (66%) were females, with a male to female ratio was 1: 2. OzakayaBayazit E et al observed that 15.38% were males and 84.62% were females with a male to female ratio of 1:5.5.…”

“…OzakayaBayazit E et al observed that 15.38% were males and 84.62% were females with a male to female ratio of 1:5.5. 9 Black MM et al observed that 61.9% were males and 38.1% were females. Male to female ratio was 1.63:1.…”

“…In present study we observed pigmented hyperkeratotic papules in all (100%) cases of lichen amyloidosis and biphasic amyloidosis which is in concordance with study by Salim T et al and Ozkaya-Bayazit E et al who reported hyperpigmented hyperkeratotic papules and pigmentation in all cases of lichen amyloidosis. 9,12 Tay CH et al observed that 67.5% had papules, 22.5% had plaques 7.5% had macules and 2.5% had nodules. 13 No association with any illness was found in patients with biphasic amyloidosis.…”